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Cited by 200Extracellular vesicles in diseaseMesenchymal stem cell researchRespiratory Support and Mechanisms

Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases

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Monsel, Antoine, Zhu, Ying-gang, Gudapati, Varun, Lim, Hyungsun, Lee, Jae W.·2016·Expert Opinion on Biological Therapy
DOI 10.1517/14712598.2016.1170804PMC PMC5280876
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Abstract

INTRODUCTION: Acute respiratory distress syndrome is a major cause of respiratory failure in critically ill patients. Despite extensive research into its pathophysiology, mortality remains high. No effective pharmacotherapy exists. Based largely on numerous preclinical studies, administration of mesenchymal stem or stromal cell (MSC) as a therapeutic for acute lung injury holds great promise, and clinical trials are currently underway. However, concern for the use of stem cells, specifically the risk of iatrogenic tumor formation, remains unresolved. Accumulating evidence now suggest that novel cell-free therapies including MSC-derived conditioned medium and extracellular vesicles released from MSCs might constitute compelling alternatives. AREAS COVERED: The current review summarizes the preclinical studies testing MSC conditioned medium and/or MSC extracellular vesicles as treatment for acute lung injury and other inflammatory lung diseases. EXPERT OPINION: While certain logistical obstacles limit the clinical applications of MSC conditioned medium such as the volume required for treatment, the therapeutic application of MSC extracellular vesicles remains promising, primarily due to ability of extracellular vesicles to maintain the functional phenotype of the parent cell. However, utilization of MSC extracellular vesicles will require large-scale production and standardization concerning identification, characterization and quantification.

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  • There are several studies revealing beneficial effects of MSCs in lung fibrosis and acute lung injury.

    “There are several studies revealing the beneficial effects of MSCs in lung fibrosis and acute lung injury [74], [171], [172], [173], [174], [175], [176], [177], [178] (Fig. 4).”

    From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [172]

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Cited by

Sorted by citations

Authors
Monsel, A., Zhu, Y.-G., Gudapati, V., Lim, H., & Lee, J. W.
Affiliations
  • Assistance Publique – Hôpitaux de Paris (FR)
  • University of California, San Francisco (US)
Corresponding author
Monsel, Antoine
ORCID
Venue
Expert Opinion on Biological Therapy
Publisher
Informa UK Limited
Published
2016-04-12
Volume
16
Issue
7
Pages
859-871
ISSN
  • 1471-2598 (ISSN-L)
  • 1744-7682
DOI
10.1517/14712598.2016.1170804
PMC
PMC5280876
OpenAlex
W2309637019
Cited by
200
References
6
Citations by year
2026: 9 · 2025: 7 · 2024: 11 · 2023: 16 · 2022: 23 · 2021: 36 · 2020: 40 · 2019: 31 · 2018: 15 · 2017: 10 · 2016: 2
FWCI
1.75
Type
journal article
Language
en
Open access
Locations
  • Expert Opinion on Biological Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (HL113022)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
mesenchymal stem cells, extracellular vesicles, MSC-conditioned medium, secretome, acute lung injury, acute respiratory distress syndrome, inflammatory lung disease, cell-free therapy, stem cell therapy safety
MeSH terms
Extracellular Vesicles, Animals, Humans, Inflammation, Lung Diseases, Culture Media, Conditioned, Mesenchymal Stem Cell Transplantation, Acute Lung Injury, Mesenchymal Stem Cells

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