New treatment strategies and emerging drugs in endometriosis
Abstract
Introduction: Endometriosis, histologically defined as the presence of endometrium-like tissue - glands and stroma - that develops outside of the uterine cavity, is still an enigmatic disease responsible for pelvic pain and infertility. The current treatments of endometriosis are surgery and hormonal therapies that act by suppressing ovulation and/or directly on steroid receptors located in endometriotic lesions. Areas covered: New hormonal and non-hormonal therapies are being developed for the treatment of endometriosis-related pain. The authors review the state of advancement and the results of novel treatments studied in registered trials ( www.ClinicalTrials.gov ). Cellular signaling pathways activated in endometriotic cells, which constitute potential targets for future treatments, are also described. Expert opinion: Therapeutic research efforts should focus on identifying and testing substances capable of acting locally on the lesions themselves, without interfering with ovulation, in order to be efficacious on both pain symptoms and infertility.
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The state of advancement and the results of novel treatments studied in registered trials have recently been reviewed.
“The state of advancement and the results of novel treatments studied in registered trials (www.ClinicalTrials.gov)have recently been reviewed.36”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [36]
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References 170 · Cited by 27
- Authors
- Streuli, I., de Ziegler, D., Borghese, B., Santulli, P., Batteux, F., & Chapron, C.
- Affiliations
- Sorbonne Paris Cité (FR)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Expert Opinion on Emerging Drugs
- Publisher
- Informa UK Limited
- Published
- 2012-03
- Volume
- 17
- Issue
- 1
- Pages
- 83-104
- ISSN
- 1472-8214 (ISSN-L)
- 1744-7623
- OpenAlex
- W1965172511
- Cited by
- 27
- References
- 170
- Citations by year
- 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Emerging Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, endometriosis-associated pain, infertility, hormone therapy, non-hormonal therapy, ovulation inhibition, steroid hormone receptors, cellular signaling pathways, endometriotic lesions, local therapy, new drugs
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