The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Polymeric carriers: role of geometry in drug delivery
Open accessAbstract
The unique properties of synthetic nanostructures promise a diverse set of applications as carriers for drug delivery, which are advantageous in terms of biocompatibility, pharmacokinetics, targeting and controlled drug release. Historically, more traditional drug delivery systems have focused on spherical carriers. However, there is a growing interest in pursuing non-spherical carriers, such as elongated or filamentous morphologies, now available due to novel formulation strategies. Unique physiochemical properties of these supramolecular structures offer distinct advantages as drug delivery systems. In particular, results of recent studies in cell cultures and lab animals indicate that rational design of carriers of a given geometry (size and shape) offers an unprecedented control of their longevity in circulation and targeting to selected cellular and subcellular locations. This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing.
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Cites
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
On the origins of morphological complexity in block copolymer surfactants
Jain, S., & Bates, F. S. (2003) · Science · doi:10.1126/science.1082193 · Cited by 1,217
Li, S. M., Garreau, H., & Vert, M. (1990) · Journal of Materials Science: Materials in Medicine · doi:10.1007/bf00700871 · Cited by 733
Polymer vesicles in vivo: correlations with PEG molecular weight
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Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target
Beningo, K. A., & Wang, Y.-L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.849 · Cited by 389
Liggins, R. T., & Burt, H. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00016-9 · Cited by 286
Cited by
Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 914
Stimuli-responsive LbL capsules and nanoshells for drug delivery
Delcea, M., Möhwald, H., & Skirtach, A. G. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.010 · Cited by 685
The importance of nanoparticle shape in cancer drug delivery
Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.950564 · Cited by 594
Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices
Lepeltier, E., Bourgaux, C., & Couvreur, P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.009 · Cited by 440
Metadata
- Authors
- Simone, E. A., Dziubla, T. D., & Muzykantov, V. R.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2008-12
- Volume
- 5
- Issue
- 12
- Pages
- 1283-1300
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2094911149
- Cited by
- 213
- References
- 6
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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