The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Vesicular carriers for dermal drug delivery
Abstract
The skin can offer several advantages as a route of drug administration although its barrier nature makes it difficult for most drugs to penetrate into and permeate through it. During the past decades there has been a lot of interest in lipid vesicles as a tool to improve drug topical delivery. Vesicular systems such as liposomes, niosomes, ethosomes and elastic, deformable vesicles provide an alternative for improved skin drug delivery. The function of vesicles as topical delivery systems is controversial with variable effects being reported in relation to the type of vesicles and their composition. In fact, vesicles can act as drug carriers controlling active release; they can provide a localized depot in the skin for dermally active compounds and enhance transdermal drug delivery. A wide variety of lipids and surfactants can be used to prepare vesicles, which are commonly composed of phospholipids (liposomes) or non-ionic surfactants (niosomes). Vesicle composition and preparation method influence their physicochemical properties (size, charge, lamellarity, thermodynamic state, deformability) and therefore their efficacy as drug delivery systems. A review of vesicle value in localizing drugs within the skin at the site of action will be provided with emphasis on their potential mechanism of action.
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Cites
The skin: an indispensable barrier
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Epidermal Lipids, Barrier Function, and Desquamation
Elias, P. M. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.12 · Cited by 1,351
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Non-ionic surfactant based vesicles (niosomes) in drug delivery
Uchegbu, I. F., & Vyas, S. P. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00169-0 · Cited by 1,020
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Particle size of liposomes influences dermal delivery of substances into skin
Verma, D. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00183-2 · Cited by 702
The skin barrier in healthy and diseased state
Bouwstra, J. A., & Ponec, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.06.021 · Cited by 666
Structure of the skin barrier and its modulation by vesicular formulations
Bouwstra, J. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00028-0 · Cited by 635
Liposomes and skin: From drug delivery to model membranes
El Maghraby, G. M., Barry, B. W., & Williams, A. C. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.05.002 · Cited by 623
Lipid vesicles for skin delivery of drugs: Reviewing three decades of research
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Cited by
Barua, S., & Mitragotri, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.008 · Cited by 1,257
Chu, L. Y., Choi, S.-O., & Prausnitz, M. R. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22140 · Cited by 259
Liu, J.-K. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00363-y · Cited by 263
Seeking better topical delivery technologies of moisturizing agents for enhanced skin moisturization
Kim, H., Kim, J. T., Barua, S., Yoo, S.-Y., Hong, S.-C., Lee, K. B., & Lee, J. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2017.1306054 · Cited by 57
Repurposing of atorvastatin emulsomes as a topical antifungal agent
Eita, A. S., M. A. Makky, A., Anter, A., & Khalil, I. A. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2149898 · Cited by 24
Metadata
- Authors
- Sinico, C., & Fadda, A. M.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2009-07-02
- Volume
- 6
- Issue
- 8
- Pages
- 813-825
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2048927441
- Cited by
- 255
- References
- 82
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
