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Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery
Abstract
IMPORTANCE OF THE FIELD: The incorporation of stimuli-responsive properties into nanostructured systems has recently attracted significant attention in the research of intracellular drug/gene delivery. In particular, numerous surface-functionalized, end-capped mesoporous silica nanoparticle (MSN) materials have been designed as efficient stimuli-responsive controlled release systems with the advantageous 'zero premature release' property. AREAS COVERED IN THIS REVIEW: Herein, the most recent research progress on the design of biocompatible, capped MSN materials for stimuli-responsive intracellular controlled release of therapeutics and genes is reviewed. A series of hard and soft caps for drug encapsulation and a variety of internal and external stimuli for controlled release of different cargoes are summarized. Recent investigations on the biocompatibility of MSN both in vitro and in vivo are also discussed. WHAT THE READER WILL GAIN: The reader will gain an understanding of the challenges for the future exploration of biocompatible stimuli-responsive MSN devices. TAKE HOME MESSAGE: With a better understanding of the unique features of capped MSN and its behaviors in biological environment, these multifunctional materials will find a wide variety of applications in the field of drug/gene delivery.
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Citations
Cited by
Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y. (2011) · ACS Nano · doi:10.1021/nn103077k · Cited by 572
Self-citationClemens, D. L., Lee, B.-Y., Xue, M., Thomas, C. R., Meng, H., Ferris, D., Nel, A. E., Zink, J. I., & Horwitz, M. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06049-11 · Cited by 260
Metadata
- Authors
- Zhao, Y., Vivero-Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S.-Y.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2010-08-18
- Volume
- 7
- Issue
- 9
- Pages
- 1013-1029
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2124273498
- Cited by
- 162
- References
- 0
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery. https://app.cochat.ai/papers/10.1517/17425247.2010.498816
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- Zhao, Y., Vivero-Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S.-Y. (2010). Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425247.2010.498816
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
