Cited by 156Dendrimers and Hyperbranched PolymersNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 112 of the 113 references it cites were found in a registry or an index.

Drug delivery using multifunctional dendrimers and hyperbranched polymers

Paleos, Constantinos M, Tsiourvas, Dimitris, Sideratou, Zili, Tziveleka, Leto-Aikaterini·2010·Expert Opinion on Drug Delivery

DOI 10.1517/17425247.2010.534981

Open this paper in CoChat — free account

Abstract

IMPORTANCE OF THE FIELD: The review presents the design strategy and synthesis of multifunctional dendrimers and hyperbranched polymers with the objective to develop effective drug delivery systems. AREAS COVERED IN THIS REVIEW: Well-characterized, commercially available dendritic polymers were subjected to functionalization for preparing drug delivery systems of low toxicity, high loading capacity, ability to target specific cells and transport through their membranes. This has been achieved by surface targeting ligands, which render the carriers specific to certain cells and polyethylene glycol groups, securing water solubility, stability and prolonged circulation. Moreover, transport agents facilitate transport through cell membranes while fluorescent probes detect their intracellular localization. A common feature of surface groups is multivalency, which considerably enhances their binding strength with complementary cell receptors. To these properties, one should also add the property of attaining high loading of active ingredients coupled with controlled and/or triggered release. WHAT THE READER WILL GAIN: Readers will be exposed to the strategy of synthesizing multifunctional polymers, aimed at the development of effective drug delivery systems. TAKE HOME MESSAGE: Multifunctional systems upgrade the therapeutic potential of drugs and, in certain cases, may even lead to the application of new bioactive compounds that would otherwise not be feasible.

Integrity signals

Registry

Crossref · 10.1517/17425247.2010.534981

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nanoparticle and targeted systems for cancer therapy
Brannon‐Peppas, L., & Blanchette, J. O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.014 · Cited by 2,335
Designing dendrimers for biological applications
Lee, C., MacKay, J. A., Fréchet, J. M. J., & Szoka, F. C. (2005) · Nature Biotechnology · doi:10.1038/nbt1171 · Cited by 2,046
Dendrimers in biomedical applications—reflections on the field
Svenson, S., & Tomalia, D. A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.018 · Cited by 1,925
Dendrimers and Other Dendritic Polymers
Fréchet, J. M. J., & Tomalia, D. A. (2001) · Wiley eBooks · doi:10.1002/0470845821 · Cited by 1,735
Chemistry for peptide and protein PEGylation
Roberts, M. J., Bentley, M. D., & Harris, J. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00022-4 · Cited by 1,628
Dendrimers and dendritic polymers in drug delivery
Gillies, E. R., & Fréchet, J. M. J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03276-3 · Cited by 1,361
Dendrimers:
Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.-W., Meijer, E. W., Paulus, W., & Duncan, R. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00246-1 · Cited by 1,228
Dendrimers and Dendrons
Newkome, G. R., Moorefield, C. N., & Vögtle, F. (2001) · Wiley eBooks · doi:10.1002/3527600612 · Cited by 1,200
Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases
Low, P. S., Henne, W. A., & Doorneweerd, D. D. (2007) · Accounts of Chemical Research · doi:10.1021/ar7000815 · Cited by 1,174
Peptide and protein PEGylation
Veronese, F. M. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00193-9 · Cited by 1,068
Discovery of dendrimers and dendritic polymers: A brief historical perspective*
Tomalia, D. A., & Fréchet, J. M. J. (2002) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.10301 · Cited by 932
Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer
Kukowska‐Latallo, J. F., Candido, K. A., Cao, Z., Nigavekar, S. S., Majoros, I., Thomas, T. P., Balogh, L. P., Khan, M. K., & Baker, J. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3921 · Cited by 912
Dendrimers and other dendritic polymers
Fréchet, J. M. J., & Tomalia, D. A. (2001) · Cited by 873
Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery
Mishra, B., Patel, B. B., & Tiwari, S. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.04.008 · Cited by 771
Parameters influencing the stealthiness of colloidal drug delivery systems
Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740
Dendrimer toxicity: Let's meet the challenge
Jain, K., Kesharwani, P., Gupta, U. D., & Jain, N. K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.027 · Cited by 711
Dendritic Polymers in Biomedical Applications: From Potential to Clinical Use in Diagnostics and Therapy
Stiriba, S., Frey, H., & Haag, R. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020415)41:8 · Cited by 678
Dendritic Polyglycerols for Biomedical Applications
Calderón, M., Quadir, M., Sharma, S. K., & Haag, R. (2009) · Advanced Materials · doi:10.1002/adma.200902144 · Cited by 636
Multivalency and Cooperativity in Supramolecular Chemistry
Badjić, J. D., Nelson, A., Cantrill, S., Turnbull, W. B., & Stoddart, J. F. (2005) · Accounts of Chemical Research · doi:10.1021/ar040223k · Cited by 636
Folate receptor targeted biodegradable polymeric doxorubicin micelles
Yoo, H. S., & Park, T. G. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.02.003 · Cited by 620
PAMAM Dendrimer-Based Multifunctional Conjugate for Cancer Therapy: Synthesis, Characterization, and Functionality
Majoros, I., Myc, A., Thomas, T. P., Mehta, C. B., & Baker, J. R. (2006) · Biomacromolecules · doi:10.1021/bm0506142 · Cited by 607
Hyperbranched Polyglycerols: From the Controlled Synthesis of Biocompatible Polyether Polyols to Multipurpose Applications
Wilms, D., Stiriba, S., & Frey, H. (2009) · Accounts of Chemical Research · doi:10.1021/ar900158p · Cited by 581
Dendrimers as versatile platform in drug delivery applications
Svenson, S. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.023 · Cited by 570
Dendrimer–drug interactions
D’Emanuele, A., & Attwood, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.012 · Cited by 570
Dendrimers: Emerging polymers for drug-delivery systems
Nanjwade, B. K., Bechra, H. M., Derkar, G. K., Manvi, F. V., & Nanjwade, V. K. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.07.008 · Cited by 543
Targeted nanoparticles for cancer therapy
Gu, F., Karnik, R., Wang, A. Z., Alexis, F., Levy‐Nissenbaum, E., Hong, S., Langer, R., & Farokhzad, O. C. (2007) · Nano Today · doi:10.1016/s1748-0132(07)70083-x · Cited by 520
Hyperbranched Aliphatic Polyesters
Malmström, E., Johansson, M. K. G., & Hult, A. (1995) · Macromolecules · doi:10.1021/ma00109a049 · Cited by 502
Functional dendrimers
Vögtle, F. (2000) · Progress in Polymer Science · doi:10.1016/s0079-6700(00)00017-4 · Cited by 491
Water-soluble dendritic unimolecular micelles:
Liu, M., Kono, K., & Fréchet, J. M. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00245-x · Cited by 477
Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid–PEG conjugates
Gabizon, A. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.01.011 · Cited by 464
On the Nature of the Multivalency Effect: A Thermodynamic Model
Kitov, P. I., & Bundle, D. R. (2003) · Journal of the American Chemical Society · doi:10.1021/ja038223n · Cited by 445
Active targeting of brain tumors using nanocarriers
Béduneau, A., Saulnier, P., & Benoît, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.011 · Cited by 433
Membrane-permeable arginine-rich peptides and the translocation mechanisms
Futaki, S. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.009 · Cited by 420
Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers
Kolhe, P. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00225-4 · Cited by 416
The "Stealth" Liposome: A Prototypical Biomaterial
Lasic, D. D., & Needham, D. (1995) · Chemical Reviews · doi:10.1021/cr00040a001 · Cited by 416
Targeted Nanoparticles for Cancer Therapy
Reddy, G. S. N. (2021) · Journal of Bioanalysis & Biomedicine · Cited by 401
Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy
Majoros, I., Thomas, T. P., Mehta, C. B., & Baker, J. R. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0401863 · Cited by 395
Poly(amidoamine), polypropylenimine, and related dendrimers and dendrons possessing different 1→2 branching motifs: An overview of the divergent procedures
Newkome, G. R., & Shreiner, C. D. (2007) · Polymer · doi:10.1016/j.polymer.2007.10.021 · Cited by 376
Targeted drug delivery via folate receptors
Zhao, X. B., Li, H., & Lee, R. J. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.3.309 · Cited by 358
Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel
Liu, Y., Li, K., Pan, J., Liu, B., & Feng, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.036 · Cited by 341
Folate and Folate−PEG−PAMAM Dendrimers: Synthesis, Characterization, and Targeted Anticancer Drug Delivery Potential in Tumor Bearing Mice
Singh, P., Gupta, U. D., Asthana, A., & Jain, N. K. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800125u · Cited by 329
Polyethylenimine with acid-labile linkages as a biodegradable gene carrier
Kim, Y. H., Park, J. H., Lee, M., Kim, Y., Park, T. G., & Kim, S. W. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.008 · Cited by 328
Advances in PEGylation of important biotech molecules: delivery aspects
Ryan, S. M., Mantovani, G., Wang, X., Haddleton, D. M., & Brayden, D. J. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.4.371 · Cited by 323
Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery
Prabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.011 · Cited by 318
Dendrimers as Drugs: Discovery and Preclinical and Clinical Development of Dendrimer-Based Microbicides for HIV and STI Prevention
McCarthy, T. D., Karellas, P., Henderson, S. A., Giannis, M. P., O'Keefe, D. F., Heery, G. P., Paull, J. R., Matthews, B. R., & Holan, G. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050023q · Cited by 314
Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells
Rothbard, J. B., Jessop, T. C., & Wender, P. A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.003 · Cited by 297
Dendrimers and Hyperbranched Polymers: Two Families of Three-Dimensional Macromolecules with Similar but Clearly Distinct Properties
Fréchet, J. M. J., Hawker, C. J., Gitsov, I., & Leon, J. W. (1996) · Journal of Macromolecular Science Part A · doi:10.1080/10601329608014916 · Cited by 287
Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice
Thomas, T. P., Majoros, I., Kotlyar, A., Kukowska‐Latallo, J. F., Bielinska, A. U., Myc, A., & Baker, J. R. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040187v · Cited by 269
Functionalized Amphiphilic Hyperbranched Polymers for Targeted Drug Delivery
Chen, S., Zhang, X., Cheng, S., Zhuo, R., & Gu, Z. (2008) · Biomacromolecules · doi:10.1021/bm800371n · Cited by 258
Peptide/Protein Hybrid Materials: Enhanced Control of Structure and Improved Performance through Conjugation of Biological and Synthetic Polymers
Vandermeulen, G. W. M., & Klok, H. (2004) · Macromolecular Bioscience · doi:10.1002/mabi.200300079 · Cited by 249
Dendrimeric micelles for controlled drug release and targeted delivery
Ambade, A. V., Savariar, E. N., & Thayumanavan, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050020d · Cited by 245
Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives
Beezer, A. E., King, A. S. H., Martin, I. K., Mitchel, J. C., Twyman, L. J., & Wain, C. F. (2003) · Tetrahedron · doi:10.1016/s0040-4020(03)00437-x · Cited by 231
Cell-penetrating peptides for drug delivery across membrane barriers
Foged, C., & Nielsen, H. M. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.1.105 · Cited by 212
Specific targeting of folate–dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts
Konda, S. D., Aref, M., Wang, S., Brechbiel, M. W., & Wiener, E. C. (2001) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf02668091 · Cited by 211
Design of Dendritic Macromolecules Containing Folate or Methotrexate Residues
Kono, K., Liu, M., & Fréchet, J. M. J. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990082k · Cited by 207
Tumor angiogenic vasculature targeting with PAMAM dendrimer–RGD conjugates
Shukla, R., Thomas, T. P., Peters, J. L., Kotlyar, A., Myc, A., & Baker, J. R. (2005) · Chemical Communications · doi:10.1039/b507350b · Cited by 205
Folate-Targeted PEG as a Potential Carrier for Carboplatin Analogs. Synthesis and in Vitro Studies
Aronov, O., Horowitz, A. T., Gabizon, A., & Gibson, D. (2003) · Bioconjugate Chemistry · doi:10.1021/bc025642l · Cited by 198
Dendrimer Internalization and Intracellular Trafficking in Living Cells
Albertazzi, L., Serresi, M., Albanese, A., & Beltram, F. (2010) · Molecular Pharmaceutics · doi:10.1021/mp9002464 · Cited by 196
Dendrimers and nanomedicine: multivalency in action
Rolland, O., Turrin, C., Caminade, A., & Majoral, J. (2009) · New Journal of Chemistry · doi:10.1039/b901054h · Cited by 196
Targeted for drug delivery
Fahmy, T. M., Fong, P., Goyal, A. K., & Saltzman, W. M. (2005) · Materials Today · doi:10.1016/s1369-7021(05)71033-6 · Cited by 192
Dendrimer-based nanoparticles for cancer therapy
Baker, J. R. (2009) · Hematology · doi:10.1182/asheducation-2009.1.708 · Cited by 191
Polyethylene glycol–polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water
Yang, H., Morris, J. J., & Lopina, S. T. (2004) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2003.12.023 · Cited by 185
Dendrimers for pharmaceutical and biomedical applications
Yang, H., & Kao, W. J. (2005) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206774879171 · Cited by 183
Synthesis and Biological Evaluation of Folate Receptor-Targeted Boronated PAMAM Dendrimers as Potential Agents for Neutron Capture Therapy
Shukla, S., Wu, G. J., Chatterjee, M., Yang, W., Sekido, M., DIOP, L. A., Müller, R., Sudimack, J. J., Lee, R. J., Barth, R. F., et al. (2002) · Bioconjugate Chemistry · doi:10.1021/bc025586o · Cited by 174
Synthesis of Novel Folic Acid-Functionalized Biocompatible Block Copolymers by Atom Transfer Radical Polymerization for Gene Delivery and Encapsulation of Hydrophobic Drugs
Licciardi, M., Tang, Y., Billingham, N. Ć., Armes, S. P., & Lewis, A. L. (2005) · Biomacromolecules · doi:10.1021/bm049271i · Cited by 152
Arginine containing peptides as delivery vectors
Tung, C., & Weissleder, R. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00183-7 · Cited by 150
Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate
Choi, S. K., Thomas, T. P., Li, M.-H., Kotlyar, A., Desai, A. M., & Baker, J. R. (2010) · Chemical Communications · doi:10.1039/b927215c · Cited by 145
Characterization of a Commercial Hyperbranched Aliphatic Polyester Based on 2,2-Bis(methylol)propionic Acid
Žagar, E., & Žigon, M. (2002) · Macromolecules · doi:10.1021/ma021070o · Cited by 133
Molecular Engineering of Dendritic Polymers and Their Application as Drug and Gene Delivery Systems
Paleos, C. M., Tsiourvas, D., & Sideratou, Z. (2007) · Molecular Pharmaceutics · doi:10.1021/mp060076n · Cited by 129
Functional dendritic polymer architectures as stimuli-responsive nanocarriers
Calderón, M., Quadir, M., Strumia, M. C., & Haag, R. (2010) · Biochimie · doi:10.1016/j.biochi.2010.02.017 · Cited by 129
Pharmaceutical and Biomedical Potential of PEGylated Dendrimers
Gajbhiye, V., Kumar, P. V., Tekade, R. K., & Jain, S. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780162999 · Cited by 124
Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances
Wiseman, H. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90283-6 · Cited by 117
Intracellular Delivery of Nanometric DNA Particles via the Folate Receptor
Dauty, E., Rémy, J.-S., Zuber, G., & Behr, J. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0255182 · Cited by 113
Acid- and Salt-Triggered Multifunctional Poly(propylene imine) Dendrimer as a Prospective Drug Delivery System
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L. (2004) · Biomacromolecules · doi:10.1021/bm030068h · Cited by 111
Characterization of commercial aliphatic hyperbranched polyesters
Žagar, E., Žigon, M., & Podzimek, Š. (2005) · Polymer · doi:10.1016/j.polymer.2005.10.142 · Cited by 109
Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers
Kojima, C., Regino, C. A. S., Umeda, Y., Kobayashi, H., & Kono, K. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.09.015 · Cited by 108
A review of in vitro–in vivo investigations on dendrimers: the novel nanoscopic drug carriers
Gupta, U. D., Agashe, H. B., Asthana, A., & Jain, N. K. (2006) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2006.04.002 · Cited by 106
Folate receptor mediated intracellular protein delivery using PLL–PEG–FOL conjugate
Kim, S. H., Jeong, J. H., Joe, C. O., & Park, T. G. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.01.006 · Cited by 98
Dendrimers: A Class of Polymers in the Nanotechnology for the Delivery of Active Pharmaceuticals
Samad, A., Alam, M., & Saxena, K. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789058200 · Cited by 97
Surface modified poly(amido)amine dendrimers as diverse nanomolecules for biomedical applications
Yellepeddi, V., Kumar, A., & Palakurthi, S. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903061251 · Cited by 95
Nanotechnologies for drug delivery: Application to cancer and autoimmune diseases
Couvreur, P., Gref, R., Andrieux, K., & Malvy, C. (2006) · Progress in Solid State Chemistry · doi:10.1016/j.progsolidstchem.2005.11.009 · Cited by 94
PEG-covered lipid surfaces: bilayers and monolayers
Needham, D., & Kim, D. H. (2000) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00147-2 · Cited by 93
Targeted Gene Delivery to Cancer Cells: Directed Assembly of Nanometric DNA Particles Coated with Folic Acid
Zuber, G., Zammut‐Italiano, L., Dauty, E., & Behr, J. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250446 · Cited by 93
Glycodendritic Structures Based on Boltorn Hyperbranched Polymers and Their Interactions with Lens culinaris Lectin
Arce, E., Nieto, P. M., Díaz, V., Castro, R. G., Bernad, A., & Rojo, J. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034008k · Cited by 86
Synthesis and Evaluation of Novel Dendrimers with a Hydrophilic Interior as Nanocarriers for Drug Delivery
Dhanikula, R. S., & Hildgen, P. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050184c · Cited by 85
HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb
Shukla, R., Thomas, T. P., Desai, A. M., Kotlyar, A., Park, S. J., & Baker, J. R. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/29/295102 · Cited by 82
PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug
Kumar, P. V., Agashe, H. B., Dutta, T., & Jain, N. K. (2006) · Current Drug Delivery · doi:10.2174/156720107779314794 · Cited by 77
Synthesis and Characterization of PAMAM Dendrimer-Based Multifunctional Nanodevices for Targeting α v β 3 Integrins
Lesniak, W. G., Kariapper, M. S. T., Nair, B. M., Tan, W., Hutson, A. D., Balogh, L. P., & Khan, M. K. (2007) · Bioconjugate Chemistry · doi:10.1021/bc070008z · Cited by 73
Novel Functional Hyperbranched Polyether Polyols as Prospective Drug Delivery Systems
Tziveleka, L., Kontoyianni, C., Sideratou, Z., Tsiourvas, D., & Paleos, C. M. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200500181 · Cited by 68
Dendrimeric Molecular Transporters: Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake
Wender, P. A., Kreider, E., Pelkey, E. T., Rothbard, J. B., & VanDeusen, C. L. (2005) · Organic Letters · doi:10.1021/ol051496y · Cited by 66
Solubilization and Release Properties of PEGylated Diaminobutane Poly(propylene imine) Dendrimers
Sideratou, Z., Tsiourvas, D., & Paleos, C. M. (2001) · Journal of Colloid and Interface Science · doi:10.1006/jcis.2001.7787 · Cited by 65
A Novel Micellar PEGylated Hyperbranched Polyester as a Prospective Drug Delivery System for Paclitaxel
Kontoyianni, C., Sideratou, Z., Theodossiou, T. A., Tziveleka, L., Tsiourvas, D., & Paleos, C. M. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200800015 · Cited by 63
Synthetic PAMAM–RGD Conjugates Target and Bind To Odontoblast-like MDPC 23 cells and the Predentin in Tooth Organ Cultures
Hill, E. E., Shukla, R., Park, S. S., & Baker, J. R. (2007) · Bioconjugate Chemistry · doi:10.1021/bc0700234 · Cited by 58
Gene delivery using functional dendritic polymers
Paleos, C. M., Tziveleka, L., Sideratou, Z., & Tsiourvas, D. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240802607345 · Cited by 58
Polymer−DNA Hybrid Nanoparticles Based on Folate−Polyethylenimine-block-poly( l -lactide)
Wang, C., & Hsiue, G. (2005) · Bioconjugate Chemistry · doi:10.1021/bc049754j · Cited by 57
Interaction and Transport of Poly( l -lysine) Dendrigrafts through Liposomal and Cellular Membranes: The Role of Generation and Surface Functionalization
Tsogas, I., Theodossiou, T. A., Sideratou, Z., Paleos, C. M., Collet, H., Rossi, J. C., Romestand, B., & Commeyras, A. (2007) · Biomacromolecules · doi:10.1021/bm700668w · Cited by 57
Liposomal Surface Potential and Bilayer Packing As Affected by PEG−Lipid Inclusion
Silvander, M., Hansson, P., & Edwards, K. (2000) · Langmuir · doi:10.1021/la9912646 · Cited by 56
Toward the Next-Generation Drug Delivery Vehicle: Synthesis of a Dendrimer with Four Orthogonally Reactive Groups
Lim, J., & Simanek, E. E. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050030e · Cited by 54
Lithium chloride as catalyst for the ring-opening polymerization of lactide in the presence of hydroxyl-containing compounds
Xie, W., Chen, D., Fan, X., Li, J., Wang, P. G., CHENG, H. N., & Nickol, R. G. (1999) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/(sici)1099-0518(19990901)37:17 · Cited by 53
Guanidinylated Dendritic Molecular Transporters: Prospective Drug Delivery Systems and Application in Cell Transfection
Theodossiou, T. A., Pantos, A., Tsogas, I., & Paleos, C. M. (2008) · ChemMedChem · doi:10.1002/cmdc.200800190 · Cited by 52
Multivalent Supramolecular Dendrimer-Based Drugs
Galeazzi, S., Hermans, T. M., Paolino, M., Anzini, M., Mennuni, L., Giordani, A., Caselli, G., Makovec, F., Meijer, E. W., Vomero, S., et al. (2009) · Biomacromolecules · doi:10.1021/bm901055a · Cited by 48
Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides
Bonduelle, C. V., & Gillies, E. R. (2010) · Pharmaceuticals · doi:10.3390/ph3030636 · Cited by 45
Screening effect of PEG on avidin binding to liposome surface receptors
Kaasgaard, T., Mouritsen, O. G., & Jørgensen, K. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00633-5 · Cited by 45
Preparation, Characterization and Pharmacokinetics of Folate Receptor-Targeted Liposomes for Docetaxel Delivery
Zhai, G., Wu, J. H., Xiang, G., Mao, W., Yu, B., Li, H., Piao, L., Lee, L. J., & Lee, R. J. (2009) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2009.450 · Cited by 44
Synthesis of a folate functionalized PEGylated poly(propylene imine) dendrimer as prospective targeted drug delivery system
Sideratou, Z., Kontoyianni, C., Drossopoulou, G. I., & Paleos, C. M. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.09.058 · Cited by 39
Modeling Cell Membrane Transport: Interaction of Guanidinylated Poly(propylene imine) Dendrimers with a Liposomal Membrane Consisting of Phosphate-Based Lipids
Tsogas, I., Tsiourvas, D., Nounesis, G., & Paleos, C. M. (2006) · Langmuir · doi:10.1021/la0620861 · Cited by 39
Multifunctional Dendritic Drug Delivery Systems: Design, Synthesis, Controlled and Triggered Release
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L. (2008) · Current Topics in Medicinal Chemistry · doi:10.2174/156802608785848996 · Cited by 38
Interactions of Complementary PEGylated Liposomes and Characterization of the Resulting Aggregates
Pantos, A., Tsiourvas, D., Sideratou, Z., Paleos, C. M., Giatrellis, S., & Nounesis, G. (2004) · Langmuir · doi:10.1021/la040026u · Cited by 34
Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI
Sideratou, Z., Tsiourvas, D., Theodossiou, T. A., Fardis, M., & Paleos, C. M. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.05.055 · Cited by 26
Interactive Transport of Guanidinylated Poly(propylene imine)‐Based Dendrimers through Liposomal and Cellular Membranes
Tsogas, I., Sideratou, Z., Tsiourvas, D., Theodossiou, T. A., & Paleos, C. M. (2007) · ChemBioChem · doi:10.1002/cbic.200700289 · Cited by 26
Tamoxifen in gynaecology
Mocanu, E. V., & Harrison, R. F. (2003) · Reviews in Gynaecological Practice · doi:10.1016/j.rigp.2003.10.002 · Cited by 7
Untitled work
(1998) · doi:10.1002/(sici)1521-3773(19981102)37:20

Research works printed but not linked: 3

Fahmy TM, 2005, Nanotoday, 8, 18
Guyton AC, Hall JE. The body fluid compartments: extracellular and intracellular fluids; interstitial fluid and edema. In textbook of medical physiology, Saunders WB Co, Philadelphia; 2000. p. 264-7
10.1021/ar7000815 · DOI

Sorted by citations

Multifunctional dendritic polymers in nanomedicine: opportunities and challenges
Khandare, J. J., Calderón, M., Dagia, N. M., & Haag, R. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15242d · Cited by 418
Bioapplications of hyperbranched polymers
Wang, D., Zhao, T., Zhu, X., Yan, D., & Wang, W. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00229f · Cited by 308
Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers
Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.025 · Cited by 286
Intelligent nanomaterials for medicine: Carrier platforms and targeting strategies in the context of clinical application
Lehner, R., Wang, X., Marsch, S. C. U., & Hunziker, P. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.01.012 · Cited by 221
Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses
Siafaka, P. I., Okur, N. Ü., Karavas, E., & Bikiaris, D. Ν. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091440 · Cited by 224

See all 156

Authors: Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A.
Affiliations: National Centre of Scientific Research "Demokritos" (GR)
ORCID: Tsiourvas, Dimitris
Sideratou, Zili
Tziveleka, Leto-Aikaterini
Venue: Expert Opinion on Drug Delivery
Publisher: Informa Healthcare
Published: 2010-11-17
Volume: 7
Issue: 12
Pages: 1387-1398
ISSN: 1742-5247 (ISSN-L)
1744-7593
DOI: 10.1517/17425247.2010.534981
OpenAlex: W2075479570
Cited by: 156
References: 113
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 19 · 2012: 14
FWCI: 11.37
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: dendrimers, hyperbranched polymers, drug delivery systems, surface functionalization, targeting ligands, polyethylene glycol, multivalency, cell membrane transport, fluorescent probes, controlled release, triggered release, drug loading capacity, polymer synthesis
MeSH terms: Animals, Drug Carriers, Humans, Polymers, Solubility, Drug Design, Gene Transfer Techniques, Dendrimers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Drug delivery using multifunctional dendrimers and hyperbranched polymers

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks