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Drug delivery using multifunctional dendrimers and hyperbranched polymers
Abstract
IMPORTANCE OF THE FIELD: The review presents the design strategy and synthesis of multifunctional dendrimers and hyperbranched polymers with the objective to develop effective drug delivery systems. AREAS COVERED IN THIS REVIEW: Well-characterized, commercially available dendritic polymers were subjected to functionalization for preparing drug delivery systems of low toxicity, high loading capacity, ability to target specific cells and transport through their membranes. This has been achieved by surface targeting ligands, which render the carriers specific to certain cells and polyethylene glycol groups, securing water solubility, stability and prolonged circulation. Moreover, transport agents facilitate transport through cell membranes while fluorescent probes detect their intracellular localization. A common feature of surface groups is multivalency, which considerably enhances their binding strength with complementary cell receptors. To these properties, one should also add the property of attaining high loading of active ingredients coupled with controlled and/or triggered release. WHAT THE READER WILL GAIN: Readers will be exposed to the strategy of synthesizing multifunctional polymers, aimed at the development of effective drug delivery systems. TAKE HOME MESSAGE: Multifunctional systems upgrade the therapeutic potential of drugs and, in certain cases, may even lead to the application of new bioactive compounds that would otherwise not be feasible.
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“Nevertheless, liposomes application and lipid-based drug delivery systems have been narrowed due to attained drug resistance and poor targeting [98,99].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [99]
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Metadata
- Authors
- Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A.
- Affiliations
- National Centre of Scientific Research "Demokritos" (GR)
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2010-11-17
- Volume
- 7
- Issue
- 12
- Pages
- 1387-1398
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2075479570
- Cited by
- 156
- References
- 113
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 19 · 2012: 14
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- dendrimers, hyperbranched polymers, drug delivery systems, surface functionalization, targeting ligands, polyethylene glycol, multivalency, cell membrane transport, fluorescent probes, controlled release, triggered release, drug loading capacity, polymer synthesis
- MeSH terms
- Animals, Drug Carriers, Humans, Polymers, Solubility, Drug Design, Gene Transfer Techniques, Dendrimers
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