The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Oral formulation strategies to improve solubility of poorly water-soluble drugs
Abstract
INTRODUCTION: In the past two decades, there has been a spiraling increase in the complexity and specificity of drug-receptor targets. It is possible to design drugs for these diverse targets with advances in combinatorial chemistry and high throughput screening. Unfortunately, but not entirely unexpectedly, these advances have been accompanied by an increase in the structural complexity and a decrease in the solubility of the active pharmaceutical ingredient. Therefore, the importance of formulation strategies to improve the solubility of poorly water-soluble drugs is inevitable, thus making it crucial to understand and explore the recent trends. AREAS COVERED: Drug delivery systems (DDS), such as solid dispersions, soluble complexes, self-emulsifying drug delivery systems (SEDDS), nanocrystals and mesoporous inorganic carriers, are discussed briefly in this review, along with examples of marketed products. This article provides the reader with a concise overview of currently relevant formulation strategies and proposes anticipated future trends. EXPERT OPINION: Today, the pharmaceutical industry has at its disposal a series of reliable and scalable formulation strategies for poorly soluble drugs. However, due to a lack of understanding of the basic physical chemistry behind these strategies, formulation development is still driven by trial and error.
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Cites
Cyclodextrins and their uses: a review
Del Valle, E. M. M. (2004) · Process Biochemistry · doi:10.1016/s0032-9592(03)00258-9 · Cited by 3,375
New developments in ordered mesoporous materials for drug delivery
Manzano, M., & Vallet-Regí, M. (2010) · Journal of Materials Chemistry · doi:10.1039/b922651f · Cited by 359
Cited by
Van den Mooter, G. (2012) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2011.10.002 · Cited by 577
Self-citationSpray drying formulation of amorphous solid dispersions
Singh, A., & Van den Mooter, G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.010 · Cited by 526
Self-citationJermain, S. V., Brough, C., & Williams, R. O. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.10.051 · Cited by 431
BCS class IV drugs: Highly notorious candidates for formulation development
Ghadi, R., & Dand, N. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.014 · Cited by 361
Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery
Brough, C., & Williams, R. O. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.05.061 · Cited by 288
Metadata
- Authors
- Singh, A., Worku, Z. A., & Van den Mooter, G.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2011-08-03
- Volume
- 8
- Issue
- 10
- Pages
- 1361-1378
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2067775495
- Cited by
- 239
- References
- 2
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Singh, A., Worku, Z. A., & Van den Mooter, G. (2011). Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425247.2011.606808
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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