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Chitosan: a potential polymer for colon-specific drug delivery system
Abstract
Introduction There is an enormous growth and awareness of the potential applications of natural polymers for colon delivery of therapeutic bioactives. Chitosan (CH), a cationic polysaccharide, has a number of vital applications in the field of colon delivery and has attracted a great deal of attention from formulation scientists, academicians and environmentalists due to its unique properties. Areas covered CH has been widely explored for the delivery of drugs, peptides, proteins and genes to the colon for different therapeutic applications. Sustained and controlled delivery can be achieved with CH-based formulations like CH-coated tablets, capsules, beads, gels, microparticles and nanoparticles. This review mainly focuses on various aspects of CH-based formulations, particularly development of colon-specific delivery of drug. Expert opinion The vital properties of CH make it a versatile excipient, not only for sustained/controlled release applications but also as biodegradable, biocompatible, bioadhesive polymer. The colon is recognized as the preferred absorption site for orally administered protein and peptide drugs. The main problem associated with CH is limited solubility at higher pH due to reduced cationic nature, which also reduces mucoadhesiveness. The application of newer targeting moiety with CH-based formulations for highly site-specific delivery of bioactive has to be evaluated for further improvement of therapeutic index (bioavailability).
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“Owing to its biodegradability via glycosidic linkage lysis by specified enzymes from the colonic microflora,35 chitosan is very valuable for CRC targeting.”
From Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment (2022) · cites this paper as [35]
In the citing paper
“In terms of colorectal cancer targeting, chitosan can form complexes with anionic drugs, reduce premature release of entrapped drugs at the upper GIT and release the encapsulant at colon part of body due to its biodegradability via glycosidic linkage lysis by means of the specified enzyme of the colonic microflora.35”
From Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment (2022) · cites this paper as [35]
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Approaches for enhancing oral bioavailability of peptides and proteins
Renukuntla, J., Vadlapudi, A. D., Patel, A., Boddu, S. H. S., & Mitra, A. K. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.030 · Cited by 681
Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
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Andishmand, H., Tabibiazar, M., Mohammadifar, M. A., & Hamishehkar, H. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.12.087 · Cited by 94
Metadata
- Authors
- Gulbake, A., & Jain, S. K.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2012-04-24
- Volume
- 9
- Issue
- 6
- Pages
- 713-729
- ISSN
- 1742-5247
- 1744-7593
- Cited by
- 81
- References
- 2
- Language
- en
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