The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recent advances in brain tumor-targeted nano-drug delivery systems
Abstract
INTRODUCTION: Brain tumors represent one of the most challenging and difficult areas in unmet medical needs. Fortunately, the past decade has seen momentous developments in brain tumor research in terms of brain tumor-targeted novel nano-drug delivery systems with significant important superiority over conventional formulations with respect to decreased toxicity and improved pharmacokinetics/pharmacodynamics. AREA COVERED: This review first introduces the characteristics of the two major obstacles in brain-tumor targeted delivery, blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB), and then reviews recent advances in brain tumor-targeted novel nano-drug delivery systems according to their targeting strategies aimed at different stages of brain tumor development and growth. EXPERT OPINION: Based on continuously changing vascular characteristics of brain tumors at different development and growth stages, we propose the concept of 'whole-process targeting' for brain tumor for nano-drug delivery systems, referring to a series of overall targeted drug delivery strategies aimed at key points during the whole development of brain tumors.
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Cites
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185
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Cited by
Crossing the blood-brain barrier with nanoparticles
Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837
Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells.
Zheng, M., Ruan, S., Liu, S., Sun, T., Qu, D., Zhao, H., Xie, Z., Gao, H., Jing, X., & Sun, Z. (2015) · ACS Nano · doi:10.1021/acsnano.5b05575 · Cited by 593
Gao, H., Yang, Z., Zhang, S., Cao, S., Shen, S., Pang, Z., & Jiang, X. (2013) · Scientific Reports · doi:10.1038/srep02534 · Cited by 306
Norouzi, M., Yathindranath, V., Thliveris, J. A., Kopec, B. M., Siahaan, T. J., & Miller, D. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-68017-y · Cited by 292
Dendrimer-Based Drug Delivery Systems for Brain Targeting
Zhu, Y., Liu, C., & Pang, Z. (2019) · Biomolecules · doi:10.3390/biom9120790 · Cited by 220
Metadata
- Authors
- Liu, Y., & Lu, W.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2012-05-18
- Volume
- 9
- Issue
- 6
- Pages
- 671-686
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2066336297
- Cited by
- 161
- References
- 4
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
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