Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells.
Abstract
A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using D-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood-brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from D-glucose (CD-G), L-asparic acid (CD-A), or D-glucose and L-glutamic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
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Excellent biocompatibility, tunable full-color emission, and the capacity to freely penetrate the BBB might make fluorescing carbon nanodots viable candidates as tagging agents to facilitate the implementation of nanomedical B/CI technologies.
“Excellent biocompatibility, tunable full-color emission, and the capacity to freely penetrate the BBB might make fluorescing carbon nanodots viable candidates as tagging agents to facilitate the implementation of nanomedical B/CI technologies”
From Human Brain/Cloud Interface (2019) · cites this paper as Zheng et al., 2015
Fluorescing carbon nanodots (synthesized using D-glucose and L-aspartic acid) with uniform diameters of 2.28 ± 0.42 nm have been employed to target and image C6 glioma cells in mouse brains.
“Fluorescing carbon nanodots (synthesized using D-glucose and L-aspartic acid) with uniform diameters of 2.28 ± 0.42 nm have been employed to target and image C6 glioma cells in mouse brains.”
From Human Brain/Cloud Interface (2019) · cites this paper as Zheng et al., 2015
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Crossing the blood-brain barrier with nanoparticles
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Neurotheranostics as Personalized Medicines
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- Authors
- Zheng, M., Ruan, S., Liu, S., Sun, T., Qu, D., Zhao, H., Xie, Z., Gao, H., Jing, X., & Sun, Z.
- Affiliations
- Chinese Academy of Sciences (CN)
- Sichuan University (CN)
- Corresponding author
- Xie, Zhigang
- Gao, Huile
- Sun, Zaicheng
- ORCID
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-16
- Volume
- 9
- Issue
- 11
- Pages
- 11455-11461
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2404671794
- Cited by
- 593
- References
- 2
- Citations by year
- 2026: 34 · 2025: 57 · 2024: 67 · 2023: 67 · 2022: 51 · 2021: 60 · 2020: 58 · 2019: 68 · 2018: 57 · 2017: 43 · 2016: 31
- FWCI
- 17.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Sciences
- Changchun Institute of Applied Chemistry
- National Natural Science Foundation of China (21201159, 51522307, 61176016, 91227118)
- Jilin Province
- State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute Of Applied Chemistry
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Carbon and Quantum Dots Applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- carbon dots, glioma, brain cancer diagnosis, fluorescence imaging, self-targeting, L-aspartic acid, D-glucose, pyrolysis synthesis, blood-brain barrier penetration, tissue distribution, non-invasive imaging, nanomedicine
- MeSH terms
- Animals, Brain Neoplasms, Carbon, Fluorescence, Glioma, Hippocampus, Quantum Dots, Cell Line, Tumor, Mice, Photoelectron Spectroscopy
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