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Drug delivery strategies for poorly water-soluble drugs
Abstract
The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or academia to develop carrier systems for the optimal oral and parenteral administration of these drugs. To mention only a few of the challenges for this class of drugs: their oral bioavailability is poor and highly variable, and carrier development for parenteral administration is faced with problems, including the massive use of surface-active excipients for solubilisation. Formulation specialists are confronted with an even higher level of difficulties when these drugs have to be delivered site specifically. This article addresses the emerging formulation designs for delivering of poorly water-soluble drugs.
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Cites
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Cited by
Baird, J. A., Van Eerdenbrugh, B., & Taylor, L. S. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22197 · Cited by 697
Merisko-Liversidge, E., & Liversidge, G. G. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.12.007 · Cited by 608
Marsac, P. J., Li, T., & Taylor, L. S. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9721-1 · Cited by 507
Molecular photoswitches in aqueous environments
Volarić, J., Szymanski, W., Simeth, N. A., & Feringa, B. L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00547a · Cited by 438
Suresh, K., & Matzger, A. J. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201907652 · Cited by 369
Metadata
- Authors
- Fahr, A., & Liu, X.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2007-07
- Volume
- 4
- Issue
- 4
- Pages
- 403-416
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2113883162
- Cited by
- 568
- References
- 1
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
