The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF)
Open accessAbstract
Encapsulating a drug molecule into a water‐reactive metal–organic framework (MOF) leads to amorphous drug confined within the nanoscale pores. Rapid release of drug occurs upon hydrolytic decomposition of MOF in dissolution media. Application to improve dissolution and solubility for the hydrophobic small drug molecules curcumin, sulindac, and triamterene is demonstrated. The drug@MOF composites exhibit significantly enhanced dissolution and achieves high supersaturation in simulated gastric and/or phosphate buffer saline media. This combination strategy where MOF inhibits crystallization of the amorphous phase and then releases drug upon MOF irreversible structural collapse represents a novel and generalizable approach for drug delivery of poorly soluble compounds while overcoming the traditional weakness of amorphous drug delivery: physical instability of the amorphous form.
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Cites
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Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy
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Cited by
Metal–Organic-Framework-Based Materials for Antimicrobial Applications
Li, R., Chen, T., & Pan, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09617 · Cited by 555
Metadata
- Authors
- Suresh, K., & Matzger, A. J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-10-11
- Volume
- 58
- Issue
- 47
- Pages
- 16790-16794
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2979549542
- Cited by
- 369
- References
- 31
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Suresh, K., & Matzger, A. J. (2019). Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF). Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201907652
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
