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Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting
Abstract
Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Chitosan NPs being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. Chitosan is natural biopolymer which can be easily functionalized to obtain the desired targeted results and is also approved by GRAS (Generally Recognized as Safe by the United States Food and Drug Administration [US FDA]). Various methods for preparation of chitosan NPs include, ionic cross-linking, covalent cross-linking, reverse micellar method, precipitation and emulsion-droplet coalescence method. Chitosan NPs are found to have plethora of applications in drug delivery diagnosis and other biological applications. The key applications include ocular drug delivery, per-oral delivery, pulmonary drug delivery, nasal drug delivery, mucosal drug delivery, gene delivery, buccal drug delivery, vaccine delivery, vaginal drug delivery and cancer therapy. The present review describes the formation of chitosan, synthesis of chitosan NPs and their various applications in drug delivery.
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“The positive surface charge of CSNPs may improve also the drug penetration by opening tight junctions of epithelial cell layers as shown in (Figure 3).134”
From Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment (2022) · cites this paper as [134]
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Cited by
Sorted by citations
Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290
Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
Choukaife, H., Seyam, S., Alallam, B., Doolaanea, A. A., & Alfatama, M. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s375229 · Cited by 127
Trends in biopolymer science applied to cosmetics
Mendoza‐Muñoz, N., Leyva‐Gómez, G., Piñón‐Segundo, E., Zambrano‐Zaragoza, M. L., Quintanar‐Guerrero, D., Del Prado Audelo, M. L., & Urbán‐Morlán, Z. (2023) · International Journal of Cosmetic Science · doi:10.1111/ics.12880 · Cited by 42
Metadata
- Authors
- Garg, U., Chauhan, S., Nagaich, U., & Jain, N.
- Venue
- Advanced Pharmaceutical Bulletin
- Publisher
- Maad Rayan Publishing Company
- Published
- 2019-06-01
- Volume
- 9
- Issue
- 2
- Pages
- 195-204
- ISSN
- 2228-5881
- 2251-7308
- PMC
- PMC6664124
- Cited by
- 505
- References
- 0
- Language
- en
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- Garg, U., Chauhan, S., Nagaich, U., & Jain, N. (2019). Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting. Advanced Pharmaceutical Bulletin. https://doi.org/10.15171/apb.2019.023
