The Gastro-protective Effect of Ginger (Zingiber officinale Roscoe) in Helicobacter pylori Positive Functional Dyspepsia
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Purpose: The present study aimed to assess the effect of ginger (Zingiber officinale) powder supplementation on Helicobacter pylori eradication and improvement of dyspeptic symptoms in patients with H. pylori positive functional dyspepsia (FD). Methods: During this pilot study 15 patients with H. pylori positive FD received 3 g/d ginger powder as three 1-g tablets for 4-weeks. Dyspepsia symptoms were asked before and after the intervention using a questionnaire based on the Rome III criteria. H. pylori eradication was also assessed by a non-invasive stool antigen (HpSAg) test. Results: Ginger consumption accompanied by significant H. pylori eradication rate of 53.3% (P = 0.019) and the odds ratio (95% CI) was 8 (1.07 to 357.14). Moreover, our results showed significant changes in most of the dyspepsia symptoms after ginger supplementation. Conclusion: According to our findings, Z. officinale can be considered as a useful complementary therapy for FD. However, due to the small number of clinical trials in this area, further welldesigned clinical trials are needed to explicitly talk about its effectiveness especially about the eradication of H. pylori.
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Ginger consumption can relieve most symptoms of functional dyspepsia such as early satiety, fullness, belching, nausea, epigastric pain, and heartburn.
“For instance, ginger consumption can relieve most symptoms of functional dyspepsia such as early satiety, fullness, belching, nausea, epigastric pain, and heartburn [14].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [14]
The Results report significant changes after ginger consumption in all six listed symptoms. However, the study involved only 15 patients with H. pylori-positive functional dyspepsia; the claim does not retain that population restriction. (LLM, conf=0.85)
Experimental — accuracy not yet measuredSeveral trials reported positive effects of ginger on at least one dyspepsia symptom, such as nausea, bloating, and abdominal pain.
“several trials reported positive effects of ginger on at least one dyspepsia symptom, such as nausea, bloating, and abdominal pain [14, 37, 41, 42].”
Long-term studies (i.e., 2-4 weeks) found significant beneficial effects of ginger on dyspepsia symptoms.
“Long-term studies (i.e., 2–4 weeks) found significant beneficial effects of ginger on dyspepsia symptoms [14, 37, 41, 42]”
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Research works printed but not linked: 22
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Cited by
Sorted by citations
Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
- Authors
- Ebrahimzadeh Attari, V., Somi, M. H., Asghari Jafarabadi, M., Ostadrahimi, A., Moaddab, S.-Y., & Lotfi, N.
- Affiliations
- Maragheh University of Medical Sciences, Maragheh, Iran.
- Tabriz University of Medical Sciences (IR)
- Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
- Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
- Corresponding author
- Ostadrahimi, Alireza
- ORCID
- Venue
- Advanced Pharmaceutical Bulletin
- Publisher
- Maad Rayan Publishing Company
- Published
- 2019-06-01
- Volume
- 9
- Issue
- 2
- Pages
- 321-324
- ISSN
- 2228-5881 (ISSN-L)
- 2251-7308
- PMC
- PMC6664109
- OpenAlex
- W2948147678
- Cited by
- 39
- References
- 0
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 1
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Advanced Pharmaceutical Bulletin (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tabriz University of Medical Sciences
- University of Tabriz
- Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- ginger, functional dyspepsia, Helicobacter pylori, Helicobacter pylori eradication, gastroprotection, dietary supplementation, complementary therapy, dyspeptic symptoms, stool antigen test
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