Effect of ginger on gastric motility and symptoms of functional dyspepsia
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Aim To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia. Methods Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained ginger (total 1.2 g) or placebo, followed after 1 h by 500 mL low-nutrient soup. Antral area, fundus area and diameter, and the frequency of antral contractions were measured using ultrasound at frequent intervals, and the gastric half-emptying time was calculated from the change in antral area. Gastrointestinal sensations and appetite were scored using visual analog questionnaires, and blood was taken for measurement of plasma glucagon-like peptide-1 (GLP-1), motilin and ghrelin concentrations, at intervals throughout the study. Results Gastric emptying was more rapid after ginger than placebo [median (range) half-emptying time 12.3 (8.5-17.0) min after ginger, 16.1 (8.3-22.6) min after placebo, P≤0.05]. There was a trend for more antral contractions (P=0.06), but fundus dimensions and gastrointestinal symptoms did not differ, nor did serum concentrations of GLP-1, motilin and ghrelin. Conclusion Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia, but had no impact on gastrointestinal symptoms or gut peptides.
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Some trials showed no effect of ginger on any dyspepsia symptoms.
“some trials showed no effect of ginger on any dyspepsia symptoms [43–45].”
Short-term studies (i.e., 1 day) did not find significant beneficial effects of ginger on dyspepsia symptoms.
“short-term studies (i.e., 1 day) did not [43–45].”
Cites
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Gastrointestinal motility enhancing effect of ginger and its active constituents.
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Walstab, J., Krüger, D., Stark, T., Hofmann, T., Demir, I. E., Ceyhan, G. O., Feistel, B., Schemann, M., & Niesler, B. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12107 · Cited by 81 · see citing works
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Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
The Effects of Ginger on Gallbladder Motility in Healthy Male Humans
Chuah, S.-K., Wu, K.-L., Tai, W.-C., & Changchien, C.-S. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.411 · Cited by 5 · see citing works
Nutritional Management in Functional Dyspepsia and Gastroparesis
Störsrud, S., Algera, J. P., & Törnblom, H. (2025) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2025.102079 · Cited by 3 · see citing works
- Authors
- Hu, M.-L.
- Affiliations
- Chang Gung University (TW)
- Corresponding author
- Hu, Ming-Luen
- ORCID
- Hu, Ming-Luen
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2011
- Volume
- 17
- Issue
- 1
- Pages
- 105
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3016669
- OpenAlex
- W2125916968
- Cited by
- 165
- References
- 2
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 14 · 2023: 19 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 17 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 12 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- ginger, functional dyspepsia, gastric motility, gastric emptying, antral contractions, gastric hormones, glucagon-like peptide-1, motilin, ghrelin, gastrointestinal symptoms, appetite
- MeSH terms
- Double-Blind Method, Dyspepsia, Gastric Emptying, Gastrointestinal Motility, Humans, Motilin, Pain Measurement, Placebos, Plant Extracts, Stomach, Zingiber officinale, Glucagon-Like Peptide 1, Ghrelin
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