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Geno/cytotoxicty and Apoptotic Properties of Phenolic Compounds from the Seeds of Dorema Glabrum Fisch. C.A
Open accessAbstract
INTRODUCTION: Dorema glabrum (Apiaceae) is a rare and monocarpic species distributed in Transcaucasia and North West of Iran. We aimed to explore anti-cancer potency of bioactive compounds from the seeds of Dorma glabrum. METHODS: Methanol extract was subjected to phytochemical investigation using normal phase Sep-pak and reversed-phase HPLC, and cytotoxic effect of isolated compounds on CAOV-4 cell line was evaluated. Furthermore, Annexin V/PI staining and comet assay were used to study genotoxicity of compounds. RESULTS: Diglucosyl caffeoyl ester (1), Glucopyranosylcaffeic acid (2) and skimmin (3), were identified. MTT cytotoxicity assay showed growth inhibition of CAOV-4 cells due to treatment with compunds (1), (2) and (3) with an IC50 of 99.7, 87.3 and 70.03 μg/ml at 48 h, respectively. Annexin V-FITC/PI staining showed occurrence of early/late apoptosis in the (1)-treated cells, while (2)-and (3)-treated cells necrosis/late apoptosis was dominant event. Single/double strands DNA breakages were observed by comet assay in all treatments. CONCLUSION: This work provides sufficient information about anti-cancer properties of the diglucosyl caffeoyl ester from the seeds of D. glabrum.
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The Ge/Pec hydrogels can be utilized as a safe carrier for controlled drug delivery.
“and can be utilized as a safe carrier for controlled drug delivery.52-56”
From pH responsive cross-linked polymeric matrices based on natural polymers: effect of process variables on swelling characterization and drug delivery properties (2017) · cites this paper as [54]
The Methods sections describe extracting Dorema glabrum seed compounds and testing their effects on cells, not evaluating Ge/Pec hydrogels. Searches for Ge/Pec, gelatin–pectin hydrogels, and controlled drug delivery found no passage addressing their safety or use as carriers. Page numbers were not available in our copy. (LLM, conf=0.78)
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Cites
Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090
A simple technique for quantitation of low levels of DNA damage in individual cells
Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828
The Systematic Identification of Flavonoids
Mabry, T. J., Markham, K. R., & Thomas, M. B. (1970) · Springer eBooks · doi:10.1007/978-3-642-88458-0 · Cited by 3,929
A Dictionary of Iranian Plant Names
Mozaffarian, & Mozaffarian, V. (1996) · Cited by 1,203
The systematic identification of flavonoids
Harbörne, J. B. (1971) · Phytochemistry · doi:10.1016/s0031-9422(00)97181-4 · Cited by 1,050
Search for antibacterial and antifungal agents from selected Indian medicinal plants
Kumar, V., Chauhan, N., Padh, H., & Rajani, M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.03.013 · Cited by 494
Regulation of the Apaf-1–caspase-9 apoptosome
Bratton, S. B., & Salvesen, G. S. (2010) · Journal of Cell Science · doi:10.1242/jcs.073643 · Cited by 434
Assadi, M., & Khatamsaz, M. (1991) · Medical Entomology and Zoology · Cited by 284
Cui, C., Tezuka, Y., Kikuchi, T., Nakano, H., Tamaoki, T., & Park, J.-H. (1990) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.38.3218 · Cited by 93
Cyto/Genotoxicity Study of Polyoxyethylene (20) Sorbitan Monolaurate (Tween 20)
Eskandani, M., Hamishehkar, H., & Ezzati, A. (2013) · DNA and Cell Biology · doi:10.1089/dna.2013.2059 · Cited by 86
Self-citationCoumarins of Matricaria chamomilla L.: Aglycones and glycosides
Petruľová, V., Repčák, M., Vilková, M., & Imrich, J. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.004 · Cited by 86
Zhang, S., Xin, H., Li, Y., Zhang, D., Shi, J., Yang, J., & Chen, X. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/819296 · Cited by 73
Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats
Zhang, S., Yang, J., Li, H., Li, Y., Liu, Y., Zhang, D., Zhang, F., Zhou, W., & Chen, X. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.017 · Cited by 62
Geno- and cytotoxicity of propyl gallate food additive
Hamishehkar, H., Khani, S., Kashanian, S., Ezzati, A., & Eskandani, M. (2013) · Drug and Chemical Toxicology · doi:10.3109/01480545.2013.838776 · Cited by 59
Self-citationEskandani, M., & Nazemiyeh, H. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.04.009 · Cited by 57
Self-citationGalbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells
Eskandani, M., Abdolalizadeh, J., Hamishehkar, H., Nazemiyeh, H., & Barar, J. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.12.003 · Cited by 57
Self-citationComet Assay: A Method to Evaluate Genotoxicity of Nano-Drug Delivery System
Vandghanooni, S., & Eskandani, M. (2011) · Europe PMC (PubMed Central) · doi:10.5681/bi.2011.012 · Cited by 44
Self-citationPhenolic constituents of Artemesia tridentata spp. Vaseyana
Brown, D., Asplund, R. O., & McMahon, V. A. (1975) · Phytochemistry · doi:10.1016/0031-9422(75)85191-0 · Cited by 40
Antioxidant phenolic compounds from the leaves ofErica Arborea(Ericaceae)
Nazemiyeh, H., Bahadorı, F., Delazar, A., Ay, M., Topçu, G., Nahar, L., Majinda, R. R. T., & Sarker, S. D. (2008) · Natural Product Research · doi:10.1080/14786410701824007 · Cited by 39
Self-citationOxidative stress level and tyrosinase activity in vitiligo patients
Hasannia, S., Eskandani, M., Golchai, J., & Pirooznia, N. (2010) · Indian Journal of Dermatology · doi:10.4103/0019-5154.60344 · Cited by 39
Self-citationEvaluation of the Antimicrobial Activity of Ammoniacum Gum from Dorema ammoniacum
Rajani, M., Saxena, N., Ravishankara, M. N., Desai, N., & Padh, H. (2002) · Pharmaceutical Biology · doi:10.1076/phbi.40.7.534.14686 · Cited by 38
Masoudi, S., Esmaeili, A., Khalilzadeh, M. A., Rustaiyan, A., Moazami, N., Akhgar, M. R., & Varavipoor, M. (2006) · Flavour and Fragrance Journal · doi:10.1002/ffj.1722 · Cited by 35
Yang, X. (2007) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20070111 · Cited by 35
A Furanocoumarin glucoside from stembark of Skimmia japonica
Reisch, J., & Achenbach, S. H. (1992) · Phytochemistry · doi:10.1016/0031-9422(92)80484-v · Cited by 31
In vitro Cytotoxic Activity of the Essential Oil of Dorema ammoniacum D. Don.
Yousefzadi, M., Heidari, M., Akbarpour, M., Mirjalili, M. H., Zeinali, A., & Parsa, M. (2011) · Cited by 23
Asnaashari, S., Dadizadeh, E., Talebpour, A. H., Eskandani, M., & Nazemiyeh, H. (2012) · Europe PMC (PubMed Central) · doi:10.5681/bi.2011.035 · Cited by 20
Self-citationIranshahi, M., Shaki, F., Mashlab, A., Porzel, A., & Wessjohann, L. A. (2007) · Journal of Natural Products · doi:10.1021/np070043u · Cited by 20
A CONTRIBUTION TO SOME ETHNOBOTANICAL ASPECTS OF BIRJAND FLORA (IRAN)
MOOD, S. G. (2008) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 20
Delnavazi, M., Hadjiakhoondi, A., Delazar, A., Ajani, Y., & Yassa, N. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-1138-2 · Cited by 17
Identification of the Hydroxycinnamtic Acid Derivatives in Cranberries
MARWAN, A. G., & NAGEL, C. W. (1982) · Journal of Food Science · doi:10.1111/j.1365-2621.1982.tb12712.x · Cited by 16
Plants of the Republic of Azerbaijan with Potential Medicinal Applications. Part III
Mir-Babayev, N. F., & Houghton, P. J. (2002) · Pharmaceutical Biology · doi:10.1076/phbi.40.1.16.5863 · Cited by 15
[Studies on chemical constituents of Saussurea laniceps].
Dawa, Z., Yan, Z., Bai, Y., Gesang, S., Xie, P., & Ding, L. (2008) · PubMed · Cited by 13
Cytotoxic Effects of Alcoholic Extract of Dorema Glabrum Seed on Cancerous Cells Viability
Amirkhiz, M. B., Rashtchizadeh, N., Nazemieh, H., Abdolalizadeh, J., Mohammadnejad, L., & Baradaran, B. (2013) · Europe PMC (PubMed Central) · doi:10.5681/apb.2013.064 · Cited by 12
Investigating Apoptotic Effects of Methanolic Extract ofDorema glabrumSeed on WEHI-164 Cells
Amirkhiz, M. B., Rashtchizadeh, N., Nazemiyeh, H., Abdolalizadeh, J., Mohammadnejad, L., & Baradaran, B. (2013) · ISRN Pharmacology · doi:10.1155/2013/949871 · Cited by 12
Self-citationGh.H., S., Moein, M. R., Foroumadi, A., & Rokhbakhsh‐Zamin, F. (2002) · Cited by 11
2,6-Dihydroxy-4-methoxyacetophenone 2-O-β-D-gentiobioside from the roots of Dorema aitchisonii
Bukreeva, T. V., & PIMENOV, M. G. (1991) · Chemistry of Natural Compounds · doi:10.1007/bf00630378 · Cited by 9
Nurmukhamedova, M. R., & Nikonov, G. K. (1976) · Chemistry of Natural Compounds · doi:10.1007/bf00570207 · Cited by 9
[Studies on chemical constituents of the roots of Angelica pubescens].
Ding, X.-F., Xu, F., Dong, Y., Zhao, X.-Z., Chen, Y., & Wang, M. (2008) · PubMed · Cited by 9
[Studies on phenolic compounds from Stellera chamaejasme].
Feng, B.-M., Gong, X., Shi, L., Jiang, G., Pei, Y., & Wang, Y. (2008) · PubMed · Cited by 6
Antimicrobial Activities of Dorema Auchri
Sharifi, A., Naghmachi, M., & Bahrami, S. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 4
Khoshvaghtı, A., Valızadeh, M., Vaseı, M., Nazıfı, S., & Akbarpour, B. (2013) · DergiPark (Istanbul University) · doi:10.16988/iuvfd.44833 · Cited by 3
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5 of the 46 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [8]Azarneushan F Karami M Golizadeh L Davary K The effect of Dorema aucheri-Hydroalcoholic extracts on thyroids hormones in adult male rats Journal of Shahrekord University of Medical Sciences 2010 12 84 8
- [18]Dehghan G Fatholahi G Sheikhzadeh N Ahmadiasl N Hypocholesteremic and antioxidant effects of Dorema glabrumextract in rats fed high cholesterol diet Journal of Iranian Chemical Society 2009 6 114 43
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Self-citationHamishehkar, H., Bahadori, M. B., Vandghanooni, S., Eskandani, M., Nakhlband, A., & Eskandani, M. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.02.017 · Cited by 75
Self-citationRasoulian, F., Eskandani, M., Jaymand, M., Nakhjavani, S. A., Farahzadi, R., Vandghanooni, S., & Eskandani, M. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105123 · Cited by 60
Self-citationJafari, S., Maleki‐Dizaji, N., Barar, J., Barzegar-Jalali, M., Rameshrad, M., & Adibkia, K. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.05.014 · Cited by 59
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Nakhlband, A., Eskandani, M., Saeedi, N., Ghafari, S., Omidi, Y., Barar, J., & Garjani, A. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.01.046 · Cited by 38
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RetractedPharmacology and Ethnomedicinal Potential of Selected Plants Species from Apiaceae (Umbelliferae)
Patra, J. K., Das, G., Das, S. K., Talukdar, A. D., Venil, C. K., Bose, S., Banerjee, S., Shin, H.-S., Gutiérrez‐Grijalva, E. P., & Heredia, J. B. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666220406110404 · Cited by 21
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Metadata
- Authors
- Eskandani, M., Dadizadeh, E., Hamishehkar, H., Nazemiyeh, H., & Barar, J.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Corresponding author
- Nazemiyeh, Hossein
- Barar, Jaleh
- Venue
- BioImpacts
- Publisher
- Maad Rayan Publishing Company
- Published
- 2017-08-23
- Volume
- 4
- Issue
- 4
- Pages
- 191-198
- ISSN
- 2228-5652 (ISSN-L)
- 2228-5660
- PMC
- PMC4298710
- OpenAlex
- W2088103792
- Cited by
- 21
- References
- 46
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Bioimpacts (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tabriz University of Medical Sciences
- University of Tabriz
- Research Center for Pharmaceutical Nanotechnology
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- phenolic compounds, seed extract, cytotoxicity, genotoxicity, apoptosis, anticancer activity, DNA damage, Apiaceae
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