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Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders
Open accessAbstract
Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress n eeds to be re-evaluated by experts.
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“Chronically ill patients of all subtypes of schizophrenia have increased levels of malondialdehyde and thiobarbituric acid reactive substances (TBARS) in blood cells (Khoubnasabjafari et al. 2015).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Khoubnasabjafari et al. 2015
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Metadata
- Authors
- Ansarin, K., Khoubnasabjafari, M., & Jouyban, A.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Corresponding author
- Jouyban, Abolghasem
- Venue
- BioImpacts
- Publisher
- Maad Rayan Publishing Company
- Published
- 2017-08-23
- Volume
- 5
- Issue
- 3
- Pages
- 123-127
- ISSN
- 2228-5652 (ISSN-L)
- 2228-5660
- PMC
- PMC4597159
- OpenAlex
- W2281377718
- Cited by
- 270
- References
- 48
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 26 · 2023: 32 · 2022: 41 · 2021: 29 · 2020: 45 · 2019: 19 · 2018: 28 · 2017: 10
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Bioimpacts (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- malondialdehyde, oxidative stress, biomarkers, mental illness, analytical reliability, lipid peroxidation, biomarker validity
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