Anti-aggregatory and fibrinolytic effects of time-released garlic powder tablets
Abstract
The double-blinded placebo-controlled randomized crossover study was performed in 29 atherosclerotic men (35 to 70 years old) suffering from cerebral atherosclerosis and chronic cerebrovascular insufficiency to elucidate the effect of time-released garlic powder tablets Allicor on platelet aggregation and serum fibrinolytic activity. It has been demonstrated that Allicor 14-days treatment significantly inhibited ADP-induced platelet aggregation by 25.4% (p<0.05) and increased plasma fibrinolytic activity by 22.4% (p<0.05). Additionally, the trend to the decrease in plasma fibrinogen level was observed. Evidence obtained from this study indicates that garlic has potential in the prevention and control of cardiovascular disorders and is beneficial when taken as a dietary supplement. We conclude that Allicor may be beneficial in protecting against cardiovascular disease as a result of inhibiting platelet aggregation and normalizing plasma fibrinolytic activity.
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Garlic extracts increased fibrinolytic activity in both healthy and acute myocardial infarction participants.
“Sobenin et al. [121] showed the plasma fibrinolytic activity of garlic extracts and they found that it increased fibrinolytic activity in both healthy and acute myocardial infarction participants.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [121]
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
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- Authors
- Sobenin, I., Andrianova, I., Ionova, V., Karagodin, V., & Orekhov, A.
- Venue
- Medical and Health Science Journal
- Publisher
- Prague Development Center
- Published
- 2012-03-22
- Volume
- 10
- Issue
- 1
- Pages
- 47-51
- ISSN
- 1804-1884 (ISSN-L)
- 1804-5014
- OpenAlex
- W2103244781
- Cited by
- 6
- References
- 31
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical and Health Science Journal (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- garlic, platelet aggregation inhibition, fibrinolysis, ADP-induced aggregation, fibrinogen, cerebral atherosclerosis, chronic cerebrovascular insufficiency, cardiovascular disease prevention, dietary supplements
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