Cited by 6Garlic and Onion StudiesBlood properties and coagulationAntiplatelet Therapy and Cardiovascular Diseases

Anti-aggregatory and fibrinolytic effects of time-released garlic powder tablets

Sobenin, Igor, Andrianova, Irina, Ionova, Viktoriya, Karagodin, Vasily, Orekhov, Alexander·2012·Medical and Health Science Journal

Abstract

The double-blinded placebo-controlled randomized crossover study was performed in 29 atherosclerotic men (35 to 70 years old) suffering from cerebral atherosclerosis and chronic cerebrovascular insufficiency to elucidate the effect of time-released garlic powder tablets Allicor on platelet aggregation and serum fibrinolytic activity. It has been demonstrated that Allicor 14-days treatment significantly inhibited ADP-induced platelet aggregation by 25.4% (p<0.05) and increased plasma fibrinolytic activity by 22.4% (p<0.05). Additionally, the trend to the decrease in plasma fibrinogen level was observed. Evidence obtained from this study indicates that garlic has potential in the prevention and control of cardiovascular disorders and is beneficial when taken as a dietary supplement. We conclude that Allicor may be beneficial in protecting against cardiovascular disease as a result of inhibiting platelet aggregation and normalizing plasma fibrinolytic activity.

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Crossref · 10.15208/mhsj.2012.9

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31 of 31 references verified0 citation errors · 0 not checkable

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Authors
Sobenin, I., Andrianova, I., Ionova, V., Karagodin, V., & Orekhov, A.
Venue
Medical and Health Science Journal
Published
2012-03-22
Volume
10
Issue
1
Pages
47-51
ISSN
  • 1804-1884 (ISSN-L)
  • 1804-5014
OpenAlex
W2103244781
Cited by
6
References
31
Citations by year
2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2013: 1
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Locations
Medical and Health Science Journal (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Keywords
garlic, platelet aggregation inhibition, fibrinolysis, ADP-induced aggregation, fibrinogen, cerebral atherosclerosis, chronic cerebrovascular insufficiency, cardiovascular disease prevention, dietary supplements

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