The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses
Open accessAbstract
Neurotrophin signaling has been implicated in the processes of synapse formation and plasticity. To gain additional insight into the mechanism of BDNF and TrkB influence on synapse formation and synaptic plasticity, we generated a conditional knock-out for TrkB using the cre/loxp system. Using three different cre-expressing transgenic mice, three unique spatial and temporal configurations of TrkB deletion were obtained with regard to the hippocampal Schaffer collateral synapse. We compare synapse formation in mutants in which TrkB is ablated either in presynaptic or in both presynaptic and postsynaptic cells at early developmental or postdevelopmental time points. Our results indicate a requirement for TrkB at both the presynaptic and postsynaptic sites during development. In the absence of TrkB, synapse numbers were significantly reduced.In vivo ablation of TrkB after synapse formation did not affect synapse numbers. In primary hippocampal cultures, deletion of TrkB in only the postsynaptic cell, before synapse formation, also resulted in deficits of synapse formation. We conclude that TrkB signaling has a cell-autonomous role required for normal development of both presynaptic and postsynaptic components of the Schaffer collateral synapse.
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Cites
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Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
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Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns
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Remodeling of Hippocampal Synaptic Networks by a Brief Anoxia–Hypoglycemia
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Cited by
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970
Self-citationFlavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832
Alcantara Llaguno, S., Chen, J., Kwon, C.-H., Jackson, E. L., Li, Y., Burns, D. K., Alvarez-Buylla, A., & Parada, L. F. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.006 · Cited by 694
Self-citationTrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634
Self-citationMonteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502
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Metadata
- Authors
- Luikart, B. W., Nef, S., Virmani, T., Lush, M. E., Liu, Y., Kavalali, E. T., & Parada, L. F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-04-13
- Volume
- 25
- Issue
- 15
- Pages
- 3774-3786
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2050389368
- Cited by
- 166
- References
- 8
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Luikart, B. W., Nef, S., Virmani, T., Lush, M. E., Liu, Y., Kavalali, E. T., & Parada, L. F. (2005). TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0041-05.2005
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