Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors.
Open accessAbstract
The mRNAs of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) exhibit a similar, though not identical, regional and cellular distribution in the rodent brain. In situ hybridization experiments have shown that BDNF, like NGF, is predominantly expressed by neurons. The neuronal localization of the mRNAs of these two neurotrophic molecules raised the question as to whether neuronal activity might be involved in the regulation of their synthesis. After we had demonstrated that depolarization with high potassium (50 mM) resulted in an increase in the levels of both BDNF and NGF mRNAs in cultures of hippocampal neurons, we investigated the effect of a large number of transmitter substances. Kainic acid, a glutamate receptor agonist, was by far the most effective in increasing BDNF and NGF mRNA levels in the neurons, but neither N-methyl-D-aspartic acid (NMDA) nor inhibitors of the NMDA glutamate receptors had any effect. However, the kainic acid mediated increase was blocked by antagonists of non-NMDA receptors. Kainic acid also elevated levels of BDNF and NGF mRNAs in rat hippocampus and cortex in vivo. These results suggest that the synthesis of these two neurotrophic factors in the brain is regulated by neuronal activity via non-NMDA glutamate receptors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BDNF synthesis, release, and action are regulated by neuronal activity.
“Synthesis, release and action of BDNF is regulated by neuronal activity and BDNF in turn leads to trophic effects such as formation, stabilization and potentiation of synapses through its high-affinity TrkB receptors.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [39]
Bdnf mRNA is regulated by neuronal activity.
“Subsequently, a similar activity-dependent regulation was observed for Bdnf mRNA39–41, and subsequent studies showed that synthesis and release of BDNF and NGF, but not those of NT-3 and NT-4, are regulated by activity9.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Monaghan, D. T., Bridges, R. J., & Cotman, C. W. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.29.040189.002053 · Cited by 2,193 · see citing works
Quantitation of mRNA by the polymerase chain reaction.
Wang, A. M., DOYLE, M. V., & Mark, D. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9717 · Cited by 1,630 · see citing works
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625 · see citing works
Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., et al. (1987) · Nature · doi:10.1038/328221a0 · Cited by 1,622 · see citing works
Glutamate neurotoxicity in cortical cell culture
Choi, D. W., Maulucci-Gedde, M., & Kriegstein, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00357.1987 · Cited by 1,506 · see citing works
Molecular cloning and expression of brain-derived neurotrophic factor
Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., & Barde, Y. (1989) · Nature · doi:10.1038/341149a0 · Cited by 1,458 · see citing works
Self-citationRegional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,017 · see citing works
Self-citationCole, A. J., Saffen, D. W., Baraban, J. M., & Worley, P. F. (1989) · Nature · doi:10.1038/340474a0 · Cited by 1,010 · see citing works
Korsching, S. I., Auburger, G. W. J., Heumann, R., Scott, J., & Thoenen, H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03791.x · Cited by 938 · see citing works
Self-citationLimbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor
Gall, C. M., & Isackson, P. J. (1989) · Science · doi:10.1126/science.2549634 · Cited by 616 · see citing works
Korsching, S. I., & Thoenen, H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.11.3513 · Cited by 562 · see citing works
Self-citationDavies, A. M., Bandtlow, C. E., Heumann, R., Korsching, S. I., Rohrer, H., & Thoenen, H. (1987) · Nature · doi:10.1038/326353a0 · Cited by 548 · see citing works
Self-citationShelton, D. L., & Reichardt, L. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2714 · Cited by 532 · see citing works
Whittemore, S. R., Ebendal, T., Lärkfors, L., Olson, L., Seiger, Å., Strömberg, I., & Persson, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.817 · Cited by 522 · see citing works
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
Johnson, J., Barde, Y., Schwab, M. E., & Thoenen, H. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-03031.1986 · Cited by 520 · see citing works
Self-citationShelton, D. L., & Reichardt, L. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7951 · Cited by 519 · see citing works
Lindsay, R. M., Thoenen, H., & Barde, Y. (1985) · Developmental Biology · doi:10.1016/0012-1606(85)90402-6 · Cited by 383 · see citing works
Self-citationBrewer, G. J., & Cotman, C. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)90144-3 · Cited by 376 · see citing works
Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones
Lindsay, R. M. (1979) · Nature · doi:10.1038/282080a0 · Cited by 373 · see citing works
Spranger, M., Lindholm, D., Bandtlow, C. E., Heumann, R., Gnahn, H., Näher‐Noé, M., & Thoenen, H. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00382.x · Cited by 371 · see citing works
Self-citationHeumann, R., Korsching, S. I., Scott, J., & Thoenen, H. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02277.x · Cited by 357 · see citing works
Self-citationExpression of the β-Nerve Growth Factor Gene in Hippocampal Neurons
Lièvre, C. A., Olson, L., Ebendal, T., Seiger, Å., & Persson, H. (1988) · Science · doi:10.1126/science.2897715 · Cited by 355 · see citing works
Cellular localization of nerve growth factor synthesis by in situ hybridization.
Bandtlow, C. E., Heumann, R., Schwab, M. E., & Thoenen, H. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04835.x · Cited by 343 · see citing works
Self-citationKainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract
McGeer, E. G., McGeer, P. L., & Singh, K. (1978) · Brain Research · doi:10.1016/0006-8993(78)90941-1 · Cited by 325 · see citing works
Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.
Hengerer, B., Lindholm, D., Heumann, R., Rüther, U., Wagner, E. F., & Thoenen, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3899 · Cited by 312 · see citing works
Self-citationRat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus
Whittemore, S. R., Friedman, P. L., Larhammar, D., Persson, H., Gonzalez-Carvajal, M., & Holets, V. R. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200402 · Cited by 308 · see citing works
Lindholm, D., Heumann, R., Hengerer, B., & Thoenen, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37599-9 · Cited by 242 · see citing works
Self-citationRodrı́guez-Tébar, A., Jeffrey, P. L., Thoenen, H., & Barde, Y. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90256-x · Cited by 157 · see citing works
Self-citationFurukawa, S., Furukawa, Y., Satoyoshi, E., & Hayashi, K. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90287-7 · Cited by 117 · see citing works
Korsching, S. I., & Thoenen, H. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-04-01058.1985 · Cited by 111 · see citing works
Self-citationNerve growth factor mRNA in brain: Localization by in situ hybridization
Rennert, P. D., & Heinrich, G. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80569-1 · Cited by 110 · see citing works
The level of nerve growth factor (NGF) as a function of innervation
Ebendal, T., Olson, L., & Seiger, Å. (1983) · Experimental Cell Research · doi:10.1016/0014-4827(83)90155-6 · Cited by 108 · see citing works
The synthesis of nerve growth factor (NGF) in developing skin is independent of innervation
Rohrer, H., Heumann, R., & Thoenen, H. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90286-2 · Cited by 83 · see citing works
Self-citationRegulation of nerve growth factor synthesis and release in organ cultures of rat iris.
Barth, E. M., Korsching, S. I., & Thoenen, H. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.3.839 · Cited by 79 · see citing works
Self-citationHeumann, R., & Thoenen, H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67646-x · Cited by 66 · see citing works
Self-citationClegg, D., Large, T. H., Bodary, S. C., & Reichardt, L. F. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90075-4 · Cited by 62 · see citing works
Nerve growth factor synthesis in cultured rat iris: Modulation by endogenous transmitter substances
Hellweg, R., Bandtlow, C. E., Heumann, R., et al. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90344-8 · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 8
- Bandtlow,C.E., Meyer,M., Lindholm,D., Spranger,M., Heumann,R. and Thoenen,H. (1990) J. Cell Biol., in press.
- Hengerer,B., Lindholm,D., Heumann,R., Ruther,U., Wagner,E.F. and Thoenen,H. (1990) Proc. Natl. Acad. Sci. USA, 87, 3899-3903.
- Korsching,S. and Thoenen,H. (1983) Proc. Natl. Acad. Sci. USA, 80, 3513-3516.
- Lindholm,D., Bandtlow,C., Spranger,M., Hengerer,B., Meyer,M., Heumann,R. and Thoenen,H. (1990) In Bjorklund,A., Aguayo,A.J. and Ottoson,D. (eds), Brain Repair. The McMillan Press, London, Vol. 96, pp. 99-112.
- Shelton,D.L. and Reichardt,L.F. (1984) Proc. Natl. Acad. -Sci. USA, 81, 7951 -7955.
- Shelton,D.L. and Reichardt,L.F. (1986) Proc. Natl. Acad. Sci. USA, 83, 2714-2718.
- Wang,A.M., Doyle,M.V. and Mark,D.F. (1989) Proc. Natl. Acad. Sci. USA, 86, 9717-9721.
- Whittemore,S.R., Ebendal,T., Lirkfors,L., Olson,L., Seiger,A., Stromberg,I. and Persson,H. (1986) Proc. Natl. Acad. Sci. USA, 83, 817-821.
Cited by
Sorted by citations
Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Self-citationNeurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works
Brain-derived neurotrophic factor and its clinical Implications
Bathina, S., & Das, U. N. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.56342 · Cited by 1,381 · see citing works
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354 · see citing works
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works
The changing scene of neurotrophic factors
Thoenen, H. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90097-e · Cited by 820 · see citing works
Self-citationPotentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A. M., Ip, N. Y., & Poo, M.-M. (1993) · Nature · doi:10.1038/363350a0 · Cited by 755 · see citing works
Neurotrophin Signaling Through the P75 Neurotrophin Receptor
Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717 · see citing works
Isackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711 · see citing works
Development and plasticity of the primary visual cortex
Espinosa, J. S., & Stryker, M. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.009 · Cited by 672 · see citing works
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
Kim, J. H., Liao, D., Lau, L.-F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)81008-9 · Cited by 634 · see citing works
Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease
Mattson, M. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.005 · Cited by 640 · see citing works
Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF
Cabelli, R. J., Hohn, A., & Shatz, C. J. (1995) · Science · doi:10.1126/science.7886458 · Cited by 566 · see citing works
Ding, Q., Vaynman, S., Akhavan, M., Ying, Z., & Gomez-Pinilla, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.084 · Cited by 555 · see citing works
Patterson, S. L., Grover, L. M., Schwartzkroin, P. A., & Bothwell, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90067-n · Cited by 555 · see citing works
Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J. P., Belzung, C., Fritschy, J.-M., Lüscher, B., & Mohler, H. (1999) · Nature Neuroscience · doi:10.1038/12207 · Cited by 550 · see citing works
Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.
Castrén, E., Zafra, F., Thoenen, H., & Lindholm, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9444 · Cited by 513 · see citing works
Self-citationVaidya, V. A., Marek, G. J., Aghajanian, G. K., & Duman, R. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02785.1997 · Cited by 479 · see citing works
Learning deficit in BDNF mutant mice.
Linnarsson, S., Björklund, A., & Ernfors, P. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01687.x · Cited by 471 · see citing works
McLaughlin, T., Torborg, C. L., Feller, M. B., & O'Leary, D. D. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00790-6 · Cited by 422 · see citing works
Glutamate and Depression: Clinical and Preclinical Studies
PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408 · see citing works
Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease
Cohen, S., & Greenberg, M. E. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175235 · Cited by 400 · see citing works
Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms
Cassilhas, R. C., Lee, K. S., Fernandes, J., Oliveira, M. G. M., Tufik, S., Meeusen, R., & de Mello, M. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.029 · Cited by 394 · see citing works
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
Cirulli, F., Berry, A., & Alleva, E. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00010-1 · Cited by 303 · see citing works
Neuronal plasticity and neurotrophic factors in drug responses
Castrén, E., & Antila, H. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.61 · Cited by 284 · see citing works
Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation
Schaaf, M. J. M., De Kloet, E. R., & Vreugdenhil, E. (2000) · Stress · doi:10.3109/10253890009001124 · Cited by 270 · see citing works
Brünig, I., Penschuck, S., Berninger, B., Benson, J., & Fritschy, J. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01506.x · Cited by 247 · see citing works
Form follows function: BDNF and its involvement in sculpting the function and structure of synapses
Zagrebelsky, M., & Korte, M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.029 · Cited by 241 · see citing works
A role for AMPA receptors in mood disorders
Alt, A., Nisenbaum, E. S., Bleakman, D., & Witkin, J. M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.022 · Cited by 238 · see citing works
Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
Li, X., Tizzano, J. P., Griffey, K., Clay, M., Lindstrom, T., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00194-5 · Cited by 225 · see citing works
Stress increases vulnerability to inflammation in the rat prefrontal cortex
de Pablos, R. M., Villarán, R. F., Argüelles, S., Herrera, A. J., Venero, J. L., Ayala, A., Cano, J., & Machado, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0802-06.2006 · Cited by 215 · see citing works
Ethell, I. M., & Yamaguchi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.575 · Cited by 209 · see citing works
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.
Woo, E., Sansing, L. H., Arnsten, A. F. T., & Datta, D. (2021) · Chronic Stress · doi:10.1177/24705470211029254 · Cited by 159 · see citing works
Jin, X., Hu, H., Mathers, P. H., & Agmon, A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05662.2003 · Cited by 137 · see citing works
Epigenetic control of neurobehavioural plasticity: the role of neurotrophins
Branchi, I., Francia, N., & Alleva, E. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200409000-00006 · Cited by 133 · see citing works
Koponen, E., Rantamäki, T., Voikar, V., Saarelainen, T., MacDonald, E., & Castrén, E. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-8468-z · Cited by 125 · see citing works
Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain
Gibon, J., & Barker, P. A. (2017) · The Neuroscientist · doi:10.1177/1073858417697037 · Cited by 115 · see citing works
Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons.
Lu, B., Yokoyama, M., Dreyfus, C. F., & Black, I. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6289 · Cited by 109 · see citing works
High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons
Andreska, T., Aufmkolk, S., Sauer, M., & Blum, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00107 · Cited by 100 · see citing works
Galuske, R. A. W., Kim, D., Castrén, E., Thoenen, H., & Singer, W. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01618.x · Cited by 93 · see citing works
Self-citationiPlasticity: Induced juvenile‐like plasticity in the adult brain as a mechanism of antidepressants
Umemori, J., Winkel, F., Didio, G., Llach Pou, M., & Castrén, E. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12683 · Cited by 80 · see citing works
Raber, J., Yamazaki, J., Torres, E. R. S., Kirchoff, N., Stagaman, K., Sharpton, T., Turker, M. S., & Kronenberg, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00179 · Cited by 78 · see citing works
Cheng, Q., & Yeh, H. H. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.037846 · Cited by 73 · see citing works
Kairisalo, M., Korhonen, L., Sepp, M., Pruunsild, P., Kukkonen, J. P., Kivinen, J., Timmusk, T., Blomgren, K., & Lindholm, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06898.x · Cited by 65 · see citing works
Self-citationKumar, A., Karuppagounder, S. S., Chen, Y., Corona, C., Kawaguchi, R., Cheng, Y., Balkaya, M., Sagdullaev, B. T., Wen, Z., Stuart, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.013 · Cited by 64 · see citing works
“28,29 Accordingly, we determined whether 2-DG depolarizes neurons to increase Bdnf expression.”
BackgroundEarly Maternal Separation increases NGF Expression in the Developing Rat Hippocampus
Cirulli, F., Micera, A., Alleva, E., & Aloe, L. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00512-1 · Cited by 63 · see citing works
Stress-induced remodeling of lymphoid innervation
Sloan, E. K., Capitanio, J. P., & Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.06.011 · Cited by 62 · see citing works
Zhang, W., Shi, Y., Peng, Y., Zhong, L., Zhu, S., Zhang, W., & Tang, S.-J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002840 · Cited by 59 · see citing works
The role of GABAergic inhibition in ocular dominance plasticity
Heimel, J. A., van Versendaal, D., & Levelt, C. N. (2011) · Neural Plasticity · doi:10.1155/2011/391763 · Cited by 57 · see citing works
Khundakar, A. A., & Thomas, A. J. (2009) · International Psychogeriatrics · doi:10.1017/s104161020999007x · Cited by 50 · see citing works
Khundakar, A., Morris, C., Oakley, A., & Thomas, A. J. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181df4642 · Cited by 42 · see citing works
Galuske, R. A. W., Kim, D., Castrén, E., & Singer, W. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00213.x · Cited by 38 · see citing works
Do, H. T., Bruelle, C., Tselykh, T., Jalonen, P., Korhonen, L., & Lindholm, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.500967 · Cited by 20 · see citing works
Self-citation
- Authors
- Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., & Lindholm, D.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- The EMBO Journal
- Published
- 1990-11-01
- Volume
- 9
- Issue
- 11
- Pages
- 3545-3550
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC552104
- OpenAlex
- W1830398839
- Cited by
- 897
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 17 · 2016: 10 · 2015: 10 · 2014: 19 · 2013: 13 · 2012: 13
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Oxford
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, nerve growth factor, non-NMDA receptors, activity-dependent gene expression, hippocampus, kainic acid, NMDA receptor antagonists, neuronal depolarization, cortical neurons
- MeSH terms
- Animals, Cells, Cultured, Dose-Response Relationship, Drug, Glutamates, Hippocampus, Kainic Acid, Membrane Potentials, Nerve Growth Factors, Nerve Tissue Proteins, Neurons, Potassium, Rats, Inbred Strains, RNA, Messenger, Blotting, Northern, Gene Expression, N-Methylaspartate, Receptors, Glutamate, Receptors, Neurotransmitter, Brain-Derived Neurotrophic Factor, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
