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Cited by 140Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative Diseases

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Cholinergic projections from the basal forebrain of rat to the amygdala

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Nagai, T, Kimura, H, Maeda, T, McGeer, PL, Peng, F, McGeer, EG·1982·The Journal of Neuroscience
DOI 10.1523/jneurosci.02-04-00513.1982PMC PMC6564247
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Abstract

Cholinergic afferents to the amygdala from the basal forebrain were studied using di-isopropyl fluorophosphate-AChE histochemistry in combination with retrograde tracing using various fluorescent dyes. Cells sending their axons to the amygdala and staining intensely for AChE were located mainly in the nucleus of the substantia innominata. They also were found in the ventral part of the globus pallidus, the horizontal limb of the nucleus tractus diagonalis Broca, and the nucleus interstitialis ansae lenticularis. A correspondence was established between these cells and cells staining for choline acetyltransferase by immunohistochemistry in both distribution and morphology. Non-cholinergic neurons which send their axons to the amygdala also were found in the substantia innominata complex.

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Crossref · 10.1523/jneurosci.02-04-00513.1982

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Figure 1.3 Adjacent sections of rat brain showing neurons of the nucleus substantia innominata stained (a) for ChAT immunohistochemistry and (b) intensely reactive for AChE following DFP treatment. Neurons, visualized by two different histochemical techniques, show similar distribution.
Figure 1.3 Adjacent sections of rat brain showing neurons of the nucleus substantia innominata stained (a) for ChAT immunohistochemistry and (b) intensely reactive for AChE following DFP treatment. Neurons, visualized by two different histochemical techniques, show similar distribution.CC-BY-NC-SA · From the PDF
Figure 2 a, Low power photomicrograph of intensely reactive AChE cells of the substantia innominata. b, High power photomicrograph of a large intensely reactive AChE neuron, indicated by the double arrowhead, seen in the nucleus substantia innominata. c, The same neuron phoot a d n ao o dy transported Primuline, visualized here as granular fluorescence. d and e, Intensely reactive cells found in the horizontal limb of nucleus tractus diagonalis Broca. Some examples (indicated by the single arrowhead) in e are labeled by the typical granular fluorescence of Primuline. Calibration bars,50μm.
Figure 2 a, Low power photomicrograph of intensely reactive AChE cells of the substantia innominata. b, High power photomicrograph of a large intensely reactive AChE neuron, indicated by the double arrowhead, seen in the nucleus substantia innominata. c, The same neuron phoot a d n ao o dy transported Primuline, visualized here as granular fluorescence. d and e, Intensely reactive cells found in the horizontal limb of nucleus tractus diagonalis Broca. Some examples (indicated by the single arrowhead) in e are labeled by the typical granular fluorescence of Primuline. Calibration bars,50μm.CC-BY-NC-SA · From the PDF
Figure 3 a, Low power magnification photomicrograph shows intensely reactive AChE cells in the medial part of the globus pallidus. b, A middle size neuron, at the bottom, shows intense AChE reaction. c, The same neuron is labeled by Primuline. Calibration bars, 50 μm.
Figure 3 a, Low power magnification photomicrograph shows intensely reactive AChE cells in the medial part of the globus pallidus. b, A middle size neuron, at the bottom, shows intense AChE reaction. c, The same neuron is labeled by Primuline. Calibration bars, 50 μm.CC-BY-NC-SA · From the PDF
Figure 4 a, Low power magnification of nucleus interstitialis ansae lenticularis AChE reaction. b, High power magnification of intensely stained cells indicated by the arrowhead. c, Fluorescent microscopic photograph of same neurons shows retrograde labeling by Primuline. Calibration bars, 50 μm.
Figure 4 a, Low power magnification of nucleus interstitialis ansae lenticularis AChE reaction. b, High power magnification of intensely stained cells indicated by the arrowhead. c, Fluorescent microscopic photograph of same neurons shows retrograde labeling by Primuline. Calibration bars, 50 μm.CC-BY-NC-SA · From the PDF
Figure 5 Distribution of cells intensely stained for AChE in the basal forebrain. The solid circles indicate cells labeled by Primuline following injection into the amygdala, while the open circles indicate those without such Primuline labeling. The shaded portion of the figure shows extent of Primuline around the injection site.
Figure 5 Distribution of cells intensely stained for AChE in the basal forebrain. The solid circles indicate cells labeled by Primuline following injection into the amygdala, while the open circles indicate those without such Primuline labeling. The shaded portion of the figure shows extent of Primuline around the injection site.CC-BY-NC-SA · From the PDF

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Citations

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Research works printed but not linked: 1

  1. Heimer, L., and R. D. WiIIson (1975) The subcortical projec- tions of the allocortex: Similarities in the neural associations of the hippocampus, the piriform cortex, and the neocortex. In Golgi Centennial Symposium, M. Santini, ed., pp. 177- 193, Raven Press, New York.

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Metadata

Authors
Nagai, T., Kimura, H., Maeda, T., McGeer, P., Peng, F., & McGeer, E.
Affiliations
University of British Columbia (CA)
ORCID
Kimura, H
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1982-04-01
Volume
2
Issue
4
Pages
513-520
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.02-04-00513.1982
PMC
PMC6564247
OpenAlex
W1949870697
Cited by
140
References
29
Citations by year
2025: 1 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 4 · 2015: 1 · 2013: 2
FWCI
7.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • OUKA (Osaka University Knowledge Archive) (Osaka University) (submittedVersion)
Funders
  • Medical Research Council Canada
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords
cholinergic projections, amygdala, basal forebrain, substantia innominata, globus pallidus, choline acetyltransferase, acetylcholinesterase histochemistry, retrograde tracing, cholinergic afferents
MeSH terms
Acetylcholinesterase, Amygdala, Animals, Brain, Choline O-Acetyltransferase, Cholinergic Fibers, Globus Pallidus, Isoflurophate, Rats

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