Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta)
Abstract
The afferent projections to the primate amygdala were studied using horseradish peroxidase. The potential advantages of this technique are discussed compared with those previously used to determine amygdaloid afferents. The findings indicate that certain agranular or dysgranular cortical regions may project directly to the amygdala: in particular, the orbital frontal cortex, anterior cingulate gyrus, subcallosal gyrus, temporal pole and anterior insula. These projections probably terminate predominantly in either the lateral or accessory basal nuclei. Other cortical projections from the inferotemporal and superior temporal gyri are described. Evidence was found for a heavy projection from the superior temporal sulcus to the lateral nucleus. Subcortical afferents were found from the hypothalamus, substantia innominata, diagonal band, thalamus, periaqueductal central gray, peripeduncular nucleus and from a band of cells extending medially from the peripeduncular nucleus to the midline, just ventral to the thalamus. In the thalamus, labelled cells were restricted to the non-specific nuclei, and were common in the rostral midline nuclei. No projection was observed from the dorsomedial nucleus of the thalamus. We discuss the implications of these results for interpreting the functions of the amygdala.
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The amygdala and insula are structurally interconnected.
“The amygdala and insula are structurally interconnected,23”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [23]
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Neuropathological observations in a case of autism presenting with self-injury behavior
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Cholinergic projections from the basal forebrain of rat to the amygdala
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Fear thou not: activity of frontal and temporal circuits in moments of real-life courage
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Extraction of prefronto-amygdalar pathways by combining probability maps
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Amygdala reactivity in healthy adults is correlated with prefrontal cortical thickness
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Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study
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- Authors
- Aggleton, J. P., Burton, M. J., & Passingham, R. E.
- Affiliations
- University of Oxford (GB)
- ORCID
- Aggleton, J.P.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1980-05
- Volume
- 190
- Issue
- 2
- Pages
- 347-368
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1977122833
- Cited by
- 610
- References
- 62
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 6 · 2023: 20 · 2022: 11 · 2021: 16 · 2020: 17 · 2019: 13 · 2018: 16 · 2017: 17 · 2016: 16 · 2015: 17 · 2014: 13 · 2013: 15 · 2012: 15
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, afferent projections, rhesus monkeys, cortical projections, subcortical projections, lateral amygdala, orbitofrontal cortex, anterior cingulate cortex, temporal pole, anterior insula, superior temporal sulcus, hypothalamus, substantia innominata, diagonal band, thalamus, periaqueductal gray
- MeSH terms
- Afferent Pathways, Amygdala, Animals, Haplorhini, Basal Ganglia, Brain Stem, Cerebral Cortex, Dominance, Cerebral, Frontal Lobe, Horseradish Peroxidase, Hypothalamus, Macaca mulatta, Mesencephalon, Parietal Lobe, Temporal Lobe, Thalamus
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