Cited by 610Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta)

Aggleton, J.P., Burton, M.J., Passingham, R.E.·1980·Brain Research

Abstract

The afferent projections to the primate amygdala were studied using horseradish peroxidase. The potential advantages of this technique are discussed compared with those previously used to determine amygdaloid afferents. The findings indicate that certain agranular or dysgranular cortical regions may project directly to the amygdala: in particular, the orbital frontal cortex, anterior cingulate gyrus, subcallosal gyrus, temporal pole and anterior insula. These projections probably terminate predominantly in either the lateral or accessory basal nuclei. Other cortical projections from the inferotemporal and superior temporal gyri are described. Evidence was found for a heavy projection from the superior temporal sulcus to the lateral nucleus. Subcortical afferents were found from the hypothalamus, substantia innominata, diagonal band, thalamus, periaqueductal central gray, peripeduncular nucleus and from a band of cells extending medially from the peripeduncular nucleus to the midline, just ventral to the thalamus. In the thalamus, labelled cells were restricted to the non-specific nuclei, and were common in the rostral midline nuclei. No projection was observed from the dorsomedial nucleus of the thalamus. We discuss the implications of these results for interpreting the functions of the amygdala.

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Crossref · 10.1016/0006-8993(80)90279-6

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Authors
Aggleton, J. P., Burton, M. J., & Passingham, R. E.
Affiliations
University of Oxford (GB)
Venue
Brain Research
Publisher
Elsevier BV
Published
1980-05
Volume
190
Issue
2
Pages
347-368
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1977122833
Cited by
610
References
62
Citations by year
2026: 11 · 2025: 11 · 2024: 6 · 2023: 20 · 2022: 11 · 2021: 16 · 2020: 17 · 2019: 13 · 2018: 16 · 2017: 17 · 2016: 16 · 2015: 17 · 2014: 13 · 2013: 15 · 2012: 15
FWCI
7.84
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
amygdala, afferent projections, rhesus monkeys, cortical projections, subcortical projections, lateral amygdala, orbitofrontal cortex, anterior cingulate cortex, temporal pole, anterior insula, superior temporal sulcus, hypothalamus, substantia innominata, diagonal band, thalamus, periaqueductal gray
MeSH terms
Afferent Pathways, Amygdala, Animals, Haplorhini, Basal Ganglia, Brain Stem, Cerebral Cortex, Dominance, Cerebral, Frontal Lobe, Horseradish Peroxidase, Hypothalamus, Macaca mulatta, Mesencephalon, Parietal Lobe, Temporal Lobe, Thalamus

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