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Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding
Open accessAbstract
Barbiturates enhance GABA receptor (sodium-independent) binding at 0°C to bovine brain membranes about 2-fold in chloride-containing buffer but not in chloride-free phosphate or Tris/ citrate buffer.This effect is observed in frozen and thawed, thoroughly washed membranes from various regions of bovine brain as well as washed membranes prepared from unfrozen rat cerebral cortex; it is destroyed by brief treatment of the membranes with the detergent Triton X-100.The enhancement is concentration-dependent, with approximately 250 pM pentobarbital giving 50% of the maximal effect seen with saturating 2 mM barbiturate.This effect is reversed by the GABA from Hoffmann-LaRoche, Inc.
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Citations
Cited by
Hevers, W., & Lüddens, H. (1998) · Molecular Neurobiology · doi:10.1007/bf02741459 · Cited by 489
General anaesthetic actions on ligand-gated ion channels
Krasowski, M. D., & Harrison, N. L. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050371 · Cited by 384
Metadata
- Authors
- Olsen, R., & Snowman, A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1982-12-01
- Volume
- 2
- Issue
- 12
- Pages
- 1812-1823
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1554442106
- Cited by
- 184
- References
- 0
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding. https://app.cochat.ai/papers/10.1523/jneurosci.02-12-01812.1982
- The paper
- Olsen, R., & Snowman, A. (1982). Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.02-12-01812.1982
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
