General anaesthetic actions on ligand-gated ion channels

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

Doyle, D., Morais-Cabral, J. H., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., & MacKinnon, R. (1998) · Science · doi:10.1126/science.280.5360.69 · Cited by 6,816 · see citing works

Magnesium gates glutamate-activated channels in mouse central neurones

Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,033 · see citing works

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works

Glycine potentiates the NMDA response in cultured mouse brain neurons

Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,151 · see citing works

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,906 · see citing works

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,644 · see citing works

Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus

Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413 · see citing works

The Membrane Actions of Anesthetics and Tranquilizers

Seeman, P. M. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06931-5 · Cited by 2,253 · see citing works

GABA_A Receptor Channels

Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975 · see citing works

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835 · see citing works

Molecular and cellular mechanisms of general anaesthesia

Franks, N. P., & Lieb, W. R. (1994) · Nature · doi:10.1038/367607a0 · Cited by 1,786 · see citing works

The physiology of excitatory amino acids in the vertebrate central nervous system

Mayer, M. L., & Westbrook, G. L. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90011-6 · Cited by 1,705 · see citing works

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

Sommer, B., Köhler, M., Sprengel, R., & Seeburg, P. H. (1991) · Cell · doi:10.1016/0092-8674(91)90568-j · Cited by 1,517 · see citing works

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,447 · see citing works

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

Kleckner, N. W., & Dingledine, R. J. (1988) · Science · doi:10.1126/science.2841759 · Cited by 1,427 · see citing works

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

Anis, N. A., Berry, S. C., Burton, N. R., & Lodge, D. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb11031.x · Cited by 1,399 · see citing works

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320 · see citing works

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

Pritchett, D. B., Sontheimer, H. W., Shivers, B. D., Ymer, S., Kettenmann, H., Schofield, P. R., & Seeburg, P. H. (1989) · Nature · doi:10.1038/338582a0 · Cited by 1,293 · see citing works

GABA _A ‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244 · see citing works

Which GABAA-receptor subtypes really occur in the brain?

McKernan, R. M., & Whiting, P. J. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80023-3 · Cited by 1,222 · see citing works

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219 · see citing works

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204 · see citing works

Glutamate receptors in the mammalian central nervous system

Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,120 · see citing works

The Time Course of Glutamate in the Synaptic Cleft

Clements, J. D., Lester, R. A. J., Tong, G., Jahr, C. E., & Westbrook, G. L. (1992) · Science · doi:10.1126/science.1359647 · Cited by 1,089 · see citing works

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works

Determination of the subunit stoichiometry of a voltage-activated potassium channel

MacKinnon, R. (1991) · Nature · doi:10.1038/350232a0 · Cited by 928 · see citing works

Minimum Alveolar Anesthetic Concentration

Eger, E. I., Saidman, L. J., & Brandstater, B. (1965) · Anesthesiology · doi:10.1097/00000542-196511000-00010 · Cited by 868 · see citing works

Contrasting properties of two forms of long-term potentiation in the hippocampus

Nicoll, R., & Malenka, R. (1995) · Nature · doi:10.1038/377115a0 · Cited by 854 · see citing works

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

Westbrook, G. L., & Mayer, M. L. (1987) · Nature · doi:10.1038/328640a0 · Cited by 852 · see citing works

Mutations in the K+ channel signature sequence

Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 834 · see citing works

The Tetrameric Structure of a Glutamate Receptor Channel

Rosenmund, C., Stern-Bach, Y., & Stevens, C. F. (1998) · Science · doi:10.1126/science.280.5369.1596 · Cited by 794 · see citing works

Pharmacological studies on presynaptic inhibition

Eccles, J. C., Schmidt, R. F., & Willis, W. D. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007205 · Cited by 757 · see citing works

Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines

Ransom, R. W., & Stec, N. L. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01818.x · Cited by 753 · see citing works

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., Monyer, H., Higuchi, M., Bach, A., & Seeburg, P. H. (1994) · Science · doi:10.1126/science.7992055 · Cited by 746 · see citing works

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

Jevtović‐Todorović, V., Todorovć, S. M., Mennerick, S. J., Powell, S., Dikranian, K. T., Benshoff, N. D., Zorumski, C. F., & Olney, J. W. (1998) · Nature Medicine · doi:10.1038/nm0498-460 · Cited by 675 · see citing works

Structure of a glutamate-receptor ligand-binding core in complex with kainate

Armstrong, N., Sun, Y., Chen, G.-Q., & Gouaux, E. (1998) · Nature · doi:10.1038/27692 · Cited by 672 · see citing works

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

Peters, S., Koh, J., & Choi, D. W. (1987) · Science · doi:10.1126/science.2883728 · Cited by 667 · see citing works

Structure and function of the NMDA receptor channel

Mori, H., & Mishina, M. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00109-j · Cited by 645 · see citing works

Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A

Das, S., Sasaki, Y., Rothe, T., Premkumar, L. S., Takasu, M. A., Crandall, J. E., Dikkes, P., Conner, D. A., Posina, V. R., Cheung, W., et al. (1998) · Nature · doi:10.1038/30748 · Cited by 611 · see citing works

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

Harrison, N. L., Majewska, M., Harrington, J. W., & Barker, J. L. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00332-5 · Cited by 611 · see citing works

A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors

Mosbacher, J., Schoepfer, R., Monyer, H., Burnashev, N., SEEBURG, P. H., & Ruppersberg, J. P. (1994) · Science · doi:10.1126/science.7973663 · Cited by 610 · see citing works

The effect of subunit composition of rat brain GABAA receptors on channel function

Sigel, E., Baur, R., Trube, G., Möhler, H., & Malherbe, P. (1990) · Neuron · doi:10.1016/0896-6273(90)90224-4 · Cited by 595 · see citing works

Determination and Applications of MAC

Quasha, A. L., Eger, E. I., & Tinker, J. H. (1980) · Anesthesiology · doi:10.1097/00000542-198010000-00008 · Cited by 592 · see citing works

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

Michaelis, E. K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00055-5 · Cited by 576 · see citing works

Do general anaesthetics act by competitive binding to specific receptors?

Franks, N. P., & Lieb, W. R. (1984) · Nature · doi:10.1038/310599a0 · Cited by 572 · see citing works

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

Traynelis, S. F., & Cull-Candy, S. G. (1990) · Nature · doi:10.1038/345347a0 · Cited by 559 · see citing works

GABA as an inhibitory neurotransmitter in human cerebral cortex

McCormick, D. A. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.5.1018 · Cited by 557 · see citing works

Anesthetic Potency (MAC) Is Independent of Forebrain Structures in the Rat

Rampil, I. J., Mason, P., & Singh, H. (1993) · Anesthesiology · doi:10.1097/00000542-199304000-00014 · Cited by 548 · see citing works

Exaggerated Anesthetic Requirements in the Preferentially Anesthetized Brain

Antognini, J. F., & Schwartz, K. R. (1993) · Anesthesiology · doi:10.1097/00000542-199312000-00015 · Cited by 527 · see citing works

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

Ortells, M. O., & Lunt, G. G. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93887-4 · Cited by 524 · see citing works

How does xenon produce anaesthesia?

Franks, N. P., Dickinson, R., de Sousa, S. L. M., Hall, A. C., & Lieb, W. R. (1998) · Nature · doi:10.1038/24525 · Cited by 514 · see citing works

Excitotoxicity and the NMDA receptor -- still lethal after eight years

Rothman, S. M. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93869-y · Cited by 508 · see citing works

Modulation of the GABA receptor complex by a steroid anaesthetic

Harrison, N. L., & Simmonds, M. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90299-3 · Cited by 501 · see citing works

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

Forrest, D., Yuzaki, M., Soares, H. D., Ng, L., Luk, D. C., Sheng, M., Stewart, C. L., Morgan, J. I., Connor, J. A., & Curran, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90350-6 · Cited by 491 · see citing works

Functional domains of GABAA receptors

Smith, G. B., & Olsen, R. W. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89009-4 · Cited by 491 · see citing works

Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2

Jia, Z., Agopyan, N., Miu, P., Xiong, Z., Henderson, J., Gerlai, R. T., Taverna, F. A., Velumian, A. A., MacDonald, J. F., Carlen, P. L., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80225-1 · Cited by 488 · see citing works

Stoichiometry and Assembly of a Recombinant GABAAReceptor Subtype

Tretter, V. E., Ehya, N., Fuchs, K., & Sieghart, W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02728.1997 · Cited by 484 · see citing works

Evidence for a Tetrameric Structure of Recombinant NMDA Receptors

Laube, B., Kuhse, J., & Betz, H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02954.1998 · Cited by 480 · see citing works

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

Mulle, C., Sailer, A. W., Pérez‐Otaño, I., Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J. R., Bettler, B., et al. (1998) · Nature · doi:10.1038/33408 · Cited by 480 · see citing works

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

Cooper, E., Couturier, S., & Ballivet, M. (1991) · Nature · doi:10.1038/350235a0 · Cited by 470 · see citing works

From ion currents to genomic analysis: Recent advances in GABAA receptor research

Rabow, L. E., Russek, S. J., & Farb, D. H. (1995) · Synapse · doi:10.1002/syn.890210302 · Cited by 469 · see citing works

Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior

Homanics, G. E., DeLorey, T. M., Firestone, L. L., Quinlan, J. J., Handforth, A., Harrison, N. L., Krasowski, M. D., Rick, C., Korpi, E. R., Mäkelä, R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4143 · Cited by 469 · see citing works

The Anesthetic Properties of Xenon in Animals and Human Beings, with Additional Observations on Krypton

Cullen, S. C., & Gross, E. G. (1951) · Science · doi:10.1126/science.113.2942.580 · Cited by 466 · see citing works

Mice Lacking the β3Subunit of the GABAAReceptor Have the Epilepsy Phenotype and Many of the Behavioral Characteristics of Angelman Syndrome

DeLorey, T. M., Handforth, A., Anagnostaras, S., Homanics, G. E., Minassian, B. A., Asatourian, A., Fanselow, M. S., Delgado‐Escueta, A. V., Ellison, G., & Olsen, R. W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08505.1998 · Cited by 459 · see citing works

Selective modulation of NMDA responses by reduction and oxidation

Aizenman, E., Lipton, S. A., & Loring, R. H. (1989) · Neuron · doi:10.1016/0896-6273(89)90310-3 · Cited by 456 · see citing works

Stoichiometry of a Recombinant GABAAReceptor

Chang, Y., Wang, R., Barot, S., & Weiss, D. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05415.1996 · Cited by 440 · see citing works

Molecular mechanisms of general anaesthesia

Franks, N. P., & Lieb, W. R. (1982) · Nature · doi:10.1038/300487a0 · Cited by 436 · see citing works

Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices.

Colquhoun, D., Jónás, P., & Sakmann, B. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019417 · Cited by 433 · see citing works

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

Cutting, G. R., Lu, L., O’Hara, B. F., Kasch, L. M., Montrose‐Rafizadeh, C., Donovan, D. M., Shimada, S., Antonarakis, S. E., Guggino, W. B., & Uhl, G. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2673 · Cited by 427 · see citing works

GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital

Αmin, J., & Weiss, D. S. (1993) · Nature · doi:10.1038/366565a0 · Cited by 426 · see citing works

Potentiation of NMDA receptor currents by arachidonic acid

Miller, B., Sarantis, M., Traynelis, S. F., & Attwell, D. (1992) · Nature · doi:10.1038/355722a0 · Cited by 425 · see citing works

Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Günther, U., Benson, J. A., Benke, D., Fritschy, J., Reyes, G., Knoflach, F., Crestani, F., Aguzzi, A., Arigoni, M., Lang, Y., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7749 · Cited by 423 · see citing works

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

Akabas, M. H., Kaufmann, C. M., Archdeacon, P., & Karlin, A. (1994) · Neuron · doi:10.1016/0896-6273(94)90257-7 · Cited by 421 · see citing works

N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1

Hollmann, M., Maron, C., & Heinemann, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90419-7 · Cited by 417 · see citing works

COMPARATIVE PHARMACOLOGY OF THE KETAMINE ISOMERS

White, P. F., Schüttler, J., Shafer, A., Stanski, D. R., Horai, Y., & Trevor, A. J. (1985) · British Journal of Anaesthesia · doi:10.1093/bja/57.2.197 · Cited by 416 · see citing works

Human neuronal nicotinic receptors

Gotti, C., Fornasari, D., & Clementi, F. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00034-8 · Cited by 413 · see citing works

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

Eiselé, J.-L., Bertrand, S., Galzi, J., Devillers‐Thiéry, A., Changeux, J., & Bertrand, D. (1993) · Nature · doi:10.1038/366479a0 · Cited by 405 · see citing works

Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit

Davies, P. A., Hanna, M. C., Hales, T. G., & Kirkness, E. F. (1997) · Nature · doi:10.1038/385820a0 · Cited by 404 · see citing works

Studien über die Narkose : zugleich ein Beitrag zur allgemeinen Pharmakologie

Overton, E. (1901) · G. Fischer eBooks · Cited by 399 · see citing works

The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

Belelli, D., Lambert, J. J., Peters, J. A., Wafford, K. A., & Whiting, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.11031 · Cited by 392 · see citing works

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

Langosch, D., Thomas, L., & Betz, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7394 · Cited by 390 · see citing works

Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.

Nusser, Z., Sieghart, W., Benke, D., Fritschy, J., & Somogyi, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11939 · Cited by 386 · see citing works

Chapter 6 Glutamate receptors and the induction of excitotoxic neuronal death

Choi, D. W. (1994) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60767-0 · Cited by 385 · see citing works

Neuronal Nicotinic Acetylcholine Receptors

Lindstrom, J. (1996) · Springer eBooks · doi:10.1007/978-1-4899-1775-1_10 · Cited by 382 · see citing works

Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates

Nicoll, R. A., Eccles, J. C., OSHIMA, T., & Rubia, F. J. (1975) · Nature · doi:10.1038/258625a0 · Cited by 373 · see citing works

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

Paternain, A. V., Morales, M., & Lerma, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90253-8 · Cited by 368 · see citing works

Nervous system distribution of the serotonin 5-HT3 receptor mRNA.

Tecott, L. H., Maricq, A. V., & Julius, D. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1430 · Cited by 368 · see citing works

Substitution of a mutant α 2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

Lakhlani, P. P., MacMillan, L. B., Guo, T., McCool, B. A., Lovinger, D. M., Maze, M., & Limbird, L. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9950 · Cited by 361 · see citing works

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

Hales, T. G., & Lambert, J. J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12479.x · Cited by 356 · see citing works

Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells

Feigenspan, A., Wässle, H., & Bormann, J. (1993) · Nature · doi:10.1038/361159a0 · Cited by 352 · see citing works

The Role of the GABAA Receptor/Chloride Channel Complex in Anesthesia

Tanelian, D. L., Kosek, P. S., Módy, I., & MacIver, M. B. (1993) · Anesthesiology · doi:10.1097/00000542-199304000-00020 · Cited by 349 · see citing works

Multiple Mechanisms of Ketamine Blockade of N-methyl-D-aspartate Receptors

Orser, B. A., Pennefather, P., & MacDonald, J. F. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00021 · Cited by 346 · see citing works

Some Physical Mechanisms in Narcosis.

Mullins, L. J. (1954) · Chemical Reviews · doi:10.1021/cr60168a003 · Cited by 344 · see citing works

Functional Architecture Of The Nicotinic Acetylcholine Receptor: From Electric Organ To Brain

Galzi, J., Revah, F., Bessis, A., & Changeux, J. (1991) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.000345 · Cited by 332 · see citing works

Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons

Frazier, C. J., Buhler, A. V., Weiner, J. L., & Dunwiddie, T. V. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08228.1998 · Cited by 329 · see citing works

GABAA receptor pharmacology

Johnston, G. A. R. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02043-8 · Cited by 320 · see citing works

NMDA receptors: from genes to channels

Sucher, N. J., Awobuluyi, M., Choi, Y., & Lipton, S. A. (1996) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)80008-3 · Cited by 316 · see citing works

Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic Autoradiography

Bloom, F. E., & Iversen, L. L. (1971) · Nature · doi:10.1038/229628a0 · Cited by 307 · see citing works

KETAMINE INFUSIONS: PHARMACOKINETICS AND CLINICAL EFFECTS

Idvall, J., Ahlgren, I., Aronsen, K. F., & Stenberg, P. B. (1979) · British Journal of Anaesthesia · doi:10.1093/bja/51.12.1167 · Cited by 306 · see citing works

Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids

Peters, J. A., Kirkness, E. F., Callachan, H., Lambert, J. J., & Turner, A. J. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11646.x · Cited by 302 · see citing works

Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop

Bennett, J. A., & Dingledine, R. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90293-7 · Cited by 288 · see citing works

Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.

Barker, J. L., & Ransom, B. R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012388 · Cited by 280 · see citing works

The Effect of the Interaction of Propofol and Alfentanil on Recall, Loss of Consciousness, and the Bispectral Index

Iselin-Chaves, I. A., Flaishon, R., Sebel, P. S., Howell, S. T., Gan, T. J., Sigl, J. C., Ginsberg, B., & Glass, P. S. A. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199810000-00038 · Cited by 267 · see citing works

Modulation of the GABAA receptor by progesterone metabolites

Callachan, H., Cottrell, G. A., Hather, N. Y., Lambert, J. J., Nooney, J. M., & Peters, J. A. (1987) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1987.0049 · Cited by 252 · see citing works

Propofol and Other Intravenous Anesthetics Have Sites of Action on the γ-Aminobutyric Acid Type A Receptor Distinct from That for Isoflurane

Krasowski, M. D., Koltchine, V. V., Rick, C., Ye, Q., Finn, S. E., & Harrison, N. L. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.530 · Cited by 250 · see citing works

Inhibition by propofol (2,6 di‐isopropylphenol) of the N‐methyl‐D‐aspartate subtype of glutamate receptor in cultured hippocampal neurones

Orser, B. A., Bertlik, M., Wang, L., & MacDonald, J. F. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16660.x · Cited by 249 · see citing works

SOLUBILITY COEFFICIENTS FOR INHALED ANAESTHETICS FOR WATER, OIL AND BIOLOGICAL MEDIA

Steward, A. N., ALLOTT, P. R., Cowles, A. L., & MAPLESON, W. W. (1973) · British Journal of Anaesthesia · doi:10.1093/bja/45.3.282 · Cited by 242 · see citing works

The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.

Wingrove, P. B., Wafford, K. A., Bain, C., & Whiting, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4569 · Cited by 242 · see citing works

Subunit‐dependent interaction of the general anaesthetic etomidate with the γ‐aminobutyric acid type A receptor

Hill‐Venning, C., Belelli, D., Peters, J. A., & Lambert, J. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700927 · Cited by 239 · see citing works

A Novel Class of GABAA Receptor Subunit in Tissues of the Reproductive System

Hedblom, E., & Kirkness, E. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15346 · Cited by 237 · see citing works

Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons

Orser, B. A., Wang, L., Pennefather, P., & MacDonald, J. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07747.1994 · Cited by 237 · see citing works

Glycine receptors: heterogeneous and widespread in the mammalian brain

Betz, H. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90045-v · Cited by 236 · see citing works

The TIPS/TINS Lecture: The molecular biology of mammalian glutamate receptor channels

SEEBURG, P. H. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90047-n · Cited by 236 · see citing works

MAC of sevoflurane in humans and the New Zealand white rabbit

Scheller, M. S., Saidman, L. J., & Partridge, B. L. (1988) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03010656 · Cited by 234 · see citing works

Molecular Interactions Between Inhaled Anesthetics and Proteins

Eckenhoff, R. G., & Johansson, J. S. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01337-1 · Cited by 233 · see citing works

Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures

Mennerick, S. J., Jevtović‐Todorović, V., Todorovic, S. M., Shen, W., Olney, J. W., & Zorumski, C. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09716.1998 · Cited by 225 · see citing works

Alpha4beta2 Neuronal Nicotinic Acetylcholine Receptors in the Central Nervous System Are Inhibited by Isoflurane and Propofol, but alpha7-type Nicotinic Acetylcholine Receptors Are Unaffected

Flood, P. D., Ramírez-Latorre, J. A., & Role, L. W. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00016 · Cited by 223 · see citing works

SELECTIVE ACTIONS OF VOLATILE GENERAL ANAESTHETICS AT MOLECULAR AND CELLULAR LEVELS

Franks, N. P., & Lieb, W. R. (1993) · British Journal of Anaesthesia · doi:10.1093/bja/71.1.65 · Cited by 218 · see citing works

Propofol Activates GABAA Receptor-Chloride Ionophore Complex in Dissociated Hippocampal Pyramidal Neurons of the Rat

Hara, M., Kai, Y., & Ikemoto, Y. (1993) · Anesthesiology · doi:10.1097/00000542-199310000-00021 · Cited by 215 · see citing works

Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Granule Neurons: Role of GABAAReceptor α6 Subunit

Tia, S., Wang, J. F., Kotchabhakdi, N., & Vicini, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03630.1996 · Cited by 214 · see citing works

Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons.

Lovinger, D. M., & White, G. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12934-9 · Cited by 214 · see citing works

Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.

Hadingham, K. L., Wingrove, P. B., Bourdellès, B. L., Palmer, K. J., RAGAN, C. I., & Whiting, P. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13682-1 · Cited by 214 · see citing works

Structural Basis for the Inhibition of Firefly Luciferase by a General Anesthetic

Franks, N. P., Jenkins, A., Conti, E., Lieb, W. R., & Brick, P. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77664-7 · Cited by 213 · see citing works

Comparison of MAC and the Rate of Rise of Alveolar Concentration of Sevoflurane with Halothane and Isoflurane in the Dog

Kazama, T., & Ikeda, K. (1988) · Anesthesiology · doi:10.1097/00000542-198803000-00020 · Cited by 212 · see citing works

Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABA A Receptor Subunit Conferring Atypical Functional Properties

Whiting, P. J., McAllister, G., Vassilatis, D. K., Bonnert, T. P., HEAVENS, R. P., Smith, D. W., Hewson, L., O’Donnell, R., Rigby, M. R., SIRINATHSINGHJI, D. J. S., et al. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05027.1997 · Cited by 211 · see citing works

Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?

Wick, M. J., Mihic, S. J., Ueno, S., Mascia, M. P., Trudell, J. R., Brozowski, S. J., Ye, Q., Harrison, N. L., & Harris, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6504 · Cited by 211 · see citing works

A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols.

Lyon, R. C., McComb, J. A., Schreurs, J., & Goldstein, D. B. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32727-8 · Cited by 209 · see citing works

Differential Sensitivities of Mammalian Neuronal and Muscle Nicotinic Acetylcholine Receptors to General Anesthetics

Violet, J. M., Downie, D. L., Nakisa, R. C., Lieb, W. R., & Franks, N. P. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00017 · Cited by 208 · see citing works

gamma-Aminobutyric acid A or C receptor? gamma-Aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive gamma-aminobutyric acid responses in Xenopus oocytes.

Shimada, S., Cutting, G. R., & Uhl, G. R. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09011-x · Cited by 206 · see citing works

Polyhalogenated and Perfluorinated Compounds that Disobey the Meyer-Overton Hypothesis

Koblin, D. D., Chortkoff, B. S., Laster, M. J., Eger, E. I., Halsey, M. J., & Ionescu, P. (1994) · Anesthesia & Analgesia · doi:10.1213/00000539-199412000-00004 · Cited by 205 · see citing works

Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform

Lavoie, A. M., Tingey, J., Harrison, N. L., Pritchett, D. B., & Twyman, R. E. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78280-8 · Cited by 205 · see citing works

Neurosteroids and GABA, receptor function

Jeremy, J., Belelli, D., Hill‐Venning, C., & Peters, J. A. (1995) · Cited by 205 · see citing works

The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex

Kuhse, J., Betz, H., & Kirsch, J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80044-1 · Cited by 205 · see citing works

Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics

Mascia, M. P., Machu, T. K., & Harris, R. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16042.x · Cited by 204 · see citing works

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

Hadingham, K. L., Wingrove, P. B., Wafford, K. A., Bain, C., Kemp, J. A., Palmer, K. J., Wilson, A. W., Wilcox, A. S., Sikela, J. M., & RAGAN, C. I. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13351-8 · Cited by 202 · see citing works

Temperature Dependence of the Potency of Volatile General Anesthetics

Franks, N. P., & Lieb, W. R. (1996) · Anesthesiology · doi:10.1097/00000542-199603000-00027 · Cited by 199 · see citing works

Comparative pharmacology of the optical isomers of ketamine in mice

Ryder, S., Way, W. L., & Trevor, A. J. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90217-0 · Cited by 199 · see citing works

Actions of anesthetics on ligand‐gated ion channels: role of receptor subunit composition

Harris, R. A., Mihic, S. J., Dildy‐Mayfield, J. E., & Machu, T. K. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.14.7589987 · Cited by 198 · see citing works

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

Xu, M., & Akabas, M. H. (1996) · The Journal of General Physiology · doi:10.1085/jgp.107.2.195 · Cited by 197 · see citing works

Motor Discoordination Results from Combined Gene Disruption of the NMDA Receptor NR2A and NR2C Subunits, But Not from Single Disruption of the NR2A or NR2C Subunit

Kadotani, H., Hirano, T., Masugi, M., Nakamura, K., Nakao, K., Katsuki, M., & Nakanishi, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-07859.1996 · Cited by 196 · see citing works

Can the Lipid Theories of Anesthesia Account for the Cutoff in Anesthetic Potency in Homologous Series of Alcohols?

Pringle, M. J., Brown, K. B., & Miller, K. W. (1981) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12536-4 · Cited by 196 · see citing works

Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation.

Wo, Z. G., & Oswald, R. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7154 · Cited by 195 · see citing works

Effects of Ethanol on Recombinant Human Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes

Cardoso, R. A., Brozowski, S. J., Chavez-Noriega, L. E., Harpold, M. M., Valenzuela, C. F., & Harris, R. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38200-x · Cited by 193 · see citing works

Enhancement of gamma‐aminobutyric acid‐activated Cl‐ currents in cultured rat hippocampal neurones by three volatile anaesthetics.

Jones, M. V., Brooks, P. A., & Harrison, N. L. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019086 · Cited by 192 · see citing works

Identification of a putative γ-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14–q21 and mouse chromosome 4

Cutting, G. R., Curristin, S. M., Zoghbi, H. Y., O’Hara, B. F., Seldin, M. F., & Uhl, G. R. (1992) · Genomics · doi:10.1016/0888-7543(92)90312-g · Cited by 191 · see citing works

Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.

Rho, J. M., Donevan, S. D., & Rogawski, M. A. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021784 · Cited by 189 · see citing works

Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

Thompson, S. A., Whiting, P. J., & Wafford, K. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15221.x · Cited by 188 · see citing works

The GABAA receptors

Stephenson, F. A. (1995) · Biochemical Journal · doi:10.1042/bj3100001 · Cited by 185 · see citing works

Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding

Olsen, R., & Snowman, A. M. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-12-01812.1982 · Cited by 184 · see citing works

Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects.

Banks, M. I., & Pearce, R. (1998) · Anesthesiology · doi:10.1097/00000542-199901000-00018 · Cited by 182 · see citing works

Alcohols and neurotransmitter gated ion channels: past, present and future

Lovinger, D. M. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005051 · Cited by 182 · see citing works

Gene Knockout of the α6 Subunit of the γ-Aminobutyric Acid Type A Receptor: Lack of Effect on Responses to Ethanol, Pentobarbital, and General Anesthetics

Homanics, G. E., Ferguson, C., Quinlan, J. J., Daggett, J., Snyder, K., Lagenaur, C. F., Mi, Z., Wang, X., Grayson, D. R., & Firestone, L. L. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.4.588 · Cited by 180 · see citing works

Chapter 10 Structure and function of neuronal nicotinic acetylcholine receptors

Lindstrom, J. M., Anand, R., Gerzanich, V., Peng, X.-D., Wang, F., & Wells, G. B. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62094-4 · Cited by 179 · see citing works

Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons

Jones, M. V., & Harrison, N. L. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1339 · Cited by 179 · see citing works

Distribution in the Brain and Metabolism of Ketamine in the Rat after Intravenous Administration

Cohen, M. L., Chan, S.-L., Way, W. L., & Trevor, A. J. (1973) · Anesthesiology · doi:10.1097/00000542-197310000-00003 · Cited by 174 · see citing works

The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones.

Vyklický, L., Vlachová, V., & Krůšek, J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018304 · Cited by 170 · see citing works

Potentiation of gamma‐aminobutyric‐acid‐activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.

Barker, J. L., Harrison, N. L., Lange, G. D., & Owen, D. G. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016547 · Cited by 168 · see citing works

Stereoselective Effects of Etomidate Optical Isomers on Gamma-aminobutyric Acid Type A Receptors and Animals

Tomlin, S. L., Jenkins, A., Lieb, W. R., & Franks, N. P. (1998) · Anesthesiology · doi:10.1097/00000542-199803000-00022 · Cited by 167 · see citing works

Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site

Alifimoff, J. K., Firestone, L. L., & Miller, K. W. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11777.x · Cited by 167 · see citing works

Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

Harrison, N. L., Kugler, J., Jones, M. V., Greenblatt, E. P., & Pritchett, D. B. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13234-3 · Cited by 167 · see citing works

Halothane, Isoflurane, and Enflurane MAC in Pregnant and Nonpregnant Female and Male Mice and Rats

Mazze, R. I., Rice, S. A., & Baden, J. M. (1985) · Anesthesiology · doi:10.1097/00000542-198503000-00021 · Cited by 165 · see citing works

The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia

Winters, W. D., Ferrer-Allado, T., Guzman-Flores, C., & Alcaraz, M. (1972) · Neuropharmacology · doi:10.1016/0028-3908(72)90016-0 · Cited by 164 · see citing works

Structure and function of inhibitory glycine receptors

Betz, H. (1992) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500004340 · Cited by 163 · see citing works

Physico-chemical correlates of alcohol intoxication

McCreery, M. J., & Hunt, W. A. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90050-3 · Cited by 159 · see citing works

Anesthesia Sensitivity in Mice that Lack the β3 Subunit of the γ-Aminobutyric Acid Type A Receptor

Quinlan, J. J., Homanics, G. E., & Firestone, L. L. (1998) · Anesthesiology · doi:10.1097/00000542-199803000-00030 · Cited by 158 · see citing works

Presynaptic ionotropic receptors

McGehee, D. S., & Role, L. W. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80118-8 · Cited by 157 · see citing works

Ethanol modulation of the gamma-aminobutyric acidA- and glycine-activated Cl- current in cultured mouse neurons.

Aguayo, L. G., & Pancetti, F. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22381-3 · Cited by 157 · see citing works

Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia.

Franks, N. P., & Lieb, W. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5116 · Cited by 156 · see citing works

Facilitatory effect of docosahexaenoic acid on N‐methyl‐D‐aspartate response in pyramidal neurones of rat cerebral cortex.

Nishikawa, M., Kimura, S., & Akaike, N. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020051 · Cited by 155 · see citing works

Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

Wafford, K. A., Whiting, P. J., & Kemp, J. A. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13605-5 · Cited by 155 · see citing works

Glutamate receptors of the kainate type and synaptic transmission

Lerma, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20055-4 · Cited by 153 · see citing works

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

Mascia, M. P., Mihic, S. J., Valenzuela, C. F., Schofield, P. R., & Harris, R. A. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09257-0 · Cited by 151 · see citing works

Potentiation of inhibition by general anaesthetics in neurones of the olfactory cortex in vitro

Scholfield, C. N. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00587527 · Cited by 151 · see citing works

The Nicotinic Acetylcholine Receptor: Structure and Autoimmune Pathology

Conti-Tronconi, B. M., McLane, K. E., Raftery, M. A., Grando, S. A., & Protti, M. P. (1994) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239409086798 · Cited by 148 · see citing works

Anesthetic actions within the spinal cord: contributions to the state of general anesthesia

Collins, J. G., Kendig, J. J., & Mason, P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98377-b · Cited by 147 · see citing works

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

Harrison, N. L., Vicini, S., & Barker, J. L. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00604.1987 · Cited by 143 · see citing works

General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium.

LIN, L. H., Chen, L. L., Zirrolli, J. A., & Harris, R. A. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10387-x · Cited by 140 · see citing works

Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin.

Gurley, D. A., Αmin, J., Ross, P. C., Weiss, D. S., & White, G. (1995) · PubMed · Cited by 140 · see citing works

Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits.

Sanna, E., Mascia, M. P., Klein, R. L., Whiting, P. J., Biggio, G., & HARRIS, R. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10610-1 · Cited by 139 · see citing works

General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons

Nakahiro, M., Yeh, J. Z., Brunner, E. E., & Narahashi, T. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.7.2541038 · Cited by 138 · see citing works

Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons

Zeilhofer, H. U., Swandulla, D., Geißlinger, G., & Brune, K. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90248-3 · Cited by 137 · see citing works

Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat

Wakamori, M., Ikemoto, Y., & Akaike, N. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.6.2014 · Cited by 136 · see citing works

Modification of NMDA Receptor Channels and Synaptic Transmission by Targeted Disruption of the NR2C Gene

Ebralidze, A. K., Rossi, D. J., Tonegawa, S., & Slater, N. T. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05014.1996 · Cited by 136 · see citing works

The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study

Pistis, M., Belelli, D., Peters, J. A., & Lambert, J. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701563 · Cited by 134 · see citing works

Enhancement of Glycine Receptor Function by Ethanol Is Inversely Correlated with Molecular Volume at Position α267

Ye, Q., Koltchine, V. V., Mihic, S. J., Mascia, M. P., Wick, M. J., Finn, S. E., Harrison, N. L., & Harris, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3314 · Cited by 134 · see citing works

Thermodynamic analysis of the relative effectiveness of narcotics

Brink, F., & Posternak, J. M. (1948) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030320208 · Cited by 132 · see citing works

Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in xenopus oocytes

Levitan, E. S., Blair, L. A. C., Dionne, V. E., & Barnard, E. A. (1988) · Neuron · doi:10.1016/0896-6273(88)90125-0 · Cited by 131 · see citing works

Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes

Downie, D. L., Hall, A. C., Lieb, W. R., & Franks, N. P. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15430.x · Cited by 131 · see citing works

Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

Lodge, D., Anis, N. A., & Burton, N. R. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90330-5 · Cited by 130 · see citing works

Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia.

Mihic, S. J., McQuilkin, S. J., Eger, E. I., Ionescu, P., & HARRIS, R. A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09824-4 · Cited by 127 · see citing works

Clinical Pharmacokinetics of Hypnotics

Breimer, D. D. (1977) · Clinical Pharmacokinetics · doi:10.2165/00003088-197702020-00002 · Cited by 125 · see citing works

Identification of Amino Acid Residues that Control Functional Behavior in GluR5 and GluR6 Kainate Receptors

Swanson, G. T., Gereau, R. W., Green, T., & Heinemann, S. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80972-1 · Cited by 124 · see citing works

Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes.

Machu, T. K., & Harris, R. A. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23856-3 · Cited by 124 · see citing works

Distribution of GABA receptor ρ subunit transcripts in the rat brain

Wegelius, K., Pasternack, M., Hiltunen, J. O., Rivera, C., Kaila, K., Saarma, M., & Reeben, M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00023.x · Cited by 123 · see citing works

Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.

Sanna, E., Garau, F., & HARRIS, R. A. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08530-x · Cited by 121 · see citing works

Stereoselective and non‐stereoselective actions of isoflurane on the GABAA receptor

Hall, A. C., Lieb, W. R., & Franks, N. P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13166.x · Cited by 118 · see citing works

Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.

Xu, M., & Akabas, M. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80569-9 · Cited by 114 · see citing works

The role of 5-HT3 receptors in drug dependence

Grant, K. A. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01120-n · Cited by 114 · see citing works

Molecular structure and function of the glycine receptor chloride channel.

Lynch, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00042.2003 · Cited by 785 · see citing works

Molecular and neuronal substrates for general anaesthetics

Rudolph, U., & Antkowiak, B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1496 · Cited by 771 · see citing works

The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway

Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568 · see citing works

General anesthetic actions <i>in vivo</i> strongly attenuated by a point mutation in the GABA _A receptor β3 subunit

Jurd, R., Arrasa, M., Lambert, S., Drexler, B., Siegwart, R., Crestani, F., Zaugg, M., Vogt, K. E., Ledermann, B., Antkowiak, B., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0611fje · Cited by 558 · see citing works

Emerging molecular mechanisms of general anesthetic action

Hemmings, H. C., Akabas, M. H., Goldstein, P. A., Trudell, J. R., Orser, B. A., & Harrison, N. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.006 · Cited by 542 · see citing works

Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin

Bhattacharya, A. A., Curry, S., & Franks, N. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005460200 · Cited by 529 · see citing works

Analysis of GABA A Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics

Rudolph, U., & Möhler, H. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121429 · Cited by 518 · see citing works

The Anesthetic Mechanism of Urethane: The Effects on Neurotransmitter-Gated Ion Channels

Hara, K., & Harris, R. A. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200202000-00015 · Cited by 497 · see citing works

Use of Anesthetic Agents in Neonates and Young Children

Mellon, R. D., Simone, A. F., & Rappaport, B. A. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000255729.96438.b0 · Cited by 395 · see citing works

Shared structural mechanisms of general anaesthetics and benzodiazepines

Kim, J. J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R. J., Zhu, S., Noviello, C., Walsh, R. M., Lindahl, E. R., & Hibbs, R. E. (2020) · Nature · doi:10.1038/s41586-020-2654-5 · Cited by 382 · see citing works

Clinical and Molecular Pharmacology of Etomidate

Forman, S. A., & Warner, D. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3181ff72b5 · Cited by 362 · see citing works

Sedation and Anesthesia Mediated by Distinct GABA _A Receptor Isoforms

Reynolds, D. S., Rosahl, T. W., Cirone, J., O'Meara, G. F., Haythornthwaite, A., Newman, R. J., Myers, J., Sur, C., Howell, O., Rutter, A. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08608.2003 · Cited by 318 · see citing works

Advances in Understanding the Actions of Nitrous Oxide

Emmanouil, D. E., & Quock, R. M. (2007) · Anesthesia Progress · doi:10.2344/0003-3006(2007)54[9:aiutao]2.0.co;2 · Cited by 257 · see citing works

Anesthetics and Ion Channels: Molecular Models and Sites of Action

Yamakura, T., Bertaccini, E. J., Trudell, J. R., & Harris, R. A. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.23 · Cited by 245 · see citing works

Competitive Inhibition at the Glycine Site of the N -Methyl-d-aspartate Receptor by the Anesthetics Xenon and Isoflurane

Dickinson, R., Peterson, B. K., Banks, P. J., Simillis, C., Martin, J. C. S., Valenzuela, C. A., Maze, M., & Franks, N. P. (2007) · Anesthesiology · doi:10.1097/01.anes.0000287061.77674.71 · Cited by 243 · see citing works

General Anesthetic Actions on GABAA Receptors

García, P. S., Kolesky, S., & Jenkins, A. (2010) · Current Neuropharmacology · doi:10.2174/157015910790909502 · Cited by 243 · see citing works

Studies on the mechanism of general anesthesia

Pavel, M. A., Petersen, E. N., Wang, H., Lerner, R. A., & Hansen, S. B. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004259117 · Cited by 205 · see citing works

5-HT3 receptors: Role in disease and target of drugs

Walstab, J., Rappold, G., & Niesler, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.001 · Cited by 203 · see citing works

Volatile anesthetics disrupt frontal-posterior recurrent information transfer at gamma frequencies in rat

Imas, O. A., Ropella, K. M., Ward, B. D., Wood, J. D., & Hudetz, A. G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.018 · Cited by 189 · see citing works

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.

Krasowski, M. D., Jenkins, A., Flood, P. D., Kung, A. Y., Hopfinger, A. J., & Harrison, N. L. (2001) · PubMed · Cited by 198 · see citing works

Effects of Xenon on In Vitro and In Vivo Models of Neuronal Injury

Wilhelm, S., Ma, D., Maze, M., & Franks, N. P. (2002) · Anesthesiology · doi:10.1097/00000542-200206000-00031 · Cited by 193 · see citing works

Modeling the effects of anesthesia on the electroencephalogram

Bojak, I., & Liley, D. T. J. (2005) · Physical Review E · doi:10.1103/physreve.71.041902 · Cited by 190 · see citing works

Defining the Propofol Binding Site Location on the GABAA Receptor

Bali, M., & Akabas, M. H. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.1.68 · Cited by 173 · see citing works

Impaired Acquisition of Spatial Memory 2 Weeks After Isoflurane and Isoflurane-Nitrous Oxide Anesthesia in Aged Rats

Culley, D. J., Baxter, M. G., Crosby, C. A., Yukhananov, R. Y., & Crosby, G. J. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000135408.14319.cc · Cited by 170 · see citing works

Crucial role of mechanisms and modes of toxic action for understanding tissue residue toxicity and internal effect concentrations of organic chemicals

Escher, B. I., Ashauer, R., Dyer, S. D., Hermens, J. L. M., Lee, J., Leslie, H. A., Mayer, P., Meador, J. P., & Warne, M. S. J. (2010) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.100 · Cited by 157 · see citing works

The Biology of General Anesthesia from Paramecium to Primate

Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works

Protein mobility and GABA-induced conformational changes in GABAA receptor pore-lining M2 segment

Horenstein, J., Wagner, D. A., Czajkowski, C., & Akabas, M. H. (2001) · Nature Neuroscience · doi:10.1038/87425 · Cited by 155 · see citing works

In vivo characterization of clinical anaesthesia and its components

Antognini, J. F., & Carstens, E. (2002) · British Journal of Anaesthesia · doi:10.1093/bja/aef156 · Cited by 155 · see citing works

Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids

Hall, A. C., Turcotte, C. M., Betts, B. A., Yeung, W.-Y., Agyeman, A. S., & Burk, L. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.10.026 · Cited by 152 · see citing works

GABAA receptors: structure and function in the basal ganglia

Goetz, T., Arslan, A., Wisden, W., & Wulff, P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)60003-4 · Cited by 149 · see citing works

The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations

Krasowski, M. D., & Harrison, N. L. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703087 · Cited by 145 · see citing works

The molecular mechanisms of general anaesthesia: dissecting the GABAA receptor

Weir, C. J. (2006) · Continuing Education in Anaesthesia Critical Care & Pain · doi:10.1093/bjaceaccp/mki068 · Cited by 143 · see citing works

Direct Structural Insights into GABAA Receptor Pharmacology

Kim, J. J., & Hibbs, R. E. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.01.011 · Cited by 139 · see citing works

Molecular determinants for the action of general anesthetics at recombinant α2β3γ2γ‐aminobutyric acidA receptors

Siegwart, R., Jurd, R., & Rudolph, U. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00682.x · Cited by 138 · see citing works

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors

Arias, H. R., Bhumireddy, P., & Bouzat, C. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.01.006 · Cited by 137 · see citing works

Methionine 286 in transmembrane domain 3 of the GABAA receptor β subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

Krasowski, M. D., Nishikawa, K., Nikolaeva, N., Lin, A., & Harrison, N. L. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00141-1 · Cited by 132 · see citing works

General anaesthetic action at transmitter-gated inhibitory amino acid receptors

Belelli, D., Pistis, M., Peters, J. A., & Lambert, J. J. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01405-4 · Cited by 132 · see citing works

Reduction of Ischemic Brain Damage by Nitrous Oxide and Xenon

David, H., Léveillé, F., Chazalviel, L., MacKenzie, E. T., Buisson, A., Lemaire, M., & Abraini, J. H. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000087342.31689.18 · Cited by 128 · see citing works

Molecular Mechanisms Transducing the Anesthetic, Analgesic, and Organ-protective Actions of Xenon

Preckel, B., Weber, N. C., Sanders, R. D., Maze, M., Schlack, W. S., & Warltier, D. C. (2006) · Anesthesiology · doi:10.1097/00000542-200607000-00029 · Cited by 125 · see citing works

Is a new paradigm needed to explain how inhaled anesthetics produce immobility?

Eger, E. I., Raines, D. E., Shafer, S. L., Hemmings, H. C., & Sonner, J. M. (2008) · Anesthesia &amp; Analgesia · doi:10.1213/ane.0b013e318182aedb · Cited by 119 · see citing works

Baseline Toxicity (Narcosis) of Organic Chemicals Determined by In Vitro Membrane Potential Measurements in Energy-Transducing Membranes

Escher, B. I., Eggen, R. I. L., Schreiber, U., Schreiber, Z., Vye, E., Wisner, B., & Schwarzenbach, R. P. (2002) · Environmental Science & Technology · doi:10.1021/es015844c · Cited by 118 · see citing works

Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain

Brannigan, G. H., LeBard, D. N., Hénin, J., Eckenhoff, R. G., & Klein, M. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008534107 · Cited by 117 · see citing works

How do general anaesthetics work?

Antkowiak, B. (2001) · Die Naturwissenschaften · doi:10.1007/s001140100230 · Cited by 112 · see citing works

Breaking the Meyer-Overton Rule: Predicted Effects of Varying Stiffness and Interfacial Activity on the Intrinsic Potency of Anesthetics

Cantor, R. S. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76200-5 · Cited by 107 · see citing works

Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia

Lugli, A. K., Yost, C. S., & Kindler, C. H. (2009) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e32832d6b0f · Cited by 105 · see citing works

Allosteric modulation of glycine receptors

Yévenes, G. E., & Zeilhofer, H. U. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01471.x · Cited by 105 · see citing works

General Anesthetic Potencies of a Series of Propofol Analogs Correlate with Potency for Potentiation of γ-Aminobutyric Acid (GABA) Current at the GABAA Receptor but Not with Lipid Solubility

Krasowski, M. D., Jenkins, A., Flood, P. D., Kung, A. Y., Hopfinger, A. J., & Harrison, N. L. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29544-6 · Cited by 106 · see citing works

Menthol Suppresses Nicotinic Acetylcholine Receptor Functioning in Sensory Neurons via Allosteric Modulation

Hans, M., Wilhelm, M., & Swandulla, D. (2012) · Chemical Senses · doi:10.1093/chemse/bjr128 · Cited by 98 · see citing works

Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition

Li, D., Chen, M., Meng, T., & Fei, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01799-0 · Cited by 96 · see citing works

Menthol shares general anesthetic activity and sites of action on the GABAA receptor with the intravenous agent, propofol

Watt, E. E., Betts, B. A., Kotey, F. O., Humbert, D. J., Griffith, T. N., Kelly, E. W., Veneskey, K. C., Gill, N., Rowan, K. C., Jenkins, A., et al. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.003 · Cited by 98 · see citing works

4D-QSAR Analysis of a Set of Propofol Analogues: Mapping Binding Sites for an Anesthetic Phenol on the GABAA Receptor

Krasowski, M. D., Hong, X., Hopfinger, A. J., & Harrison, N. L. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010461a · Cited by 98 · see citing works

Decoupled temporal variability and signal synchronization of spontaneous brain activity in loss of consciousness: An fMRI study in anesthesia

Huang, Z., Zhang, J., Jinsong, W., Qin, P., Wu, X., Wang, Z., 戴睿, Li, Y., 梁伟民, Mao, Y., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.062 · Cited by 97 · see citing works

Tolerance to allopregnanolone with focus on the GABA‐A receptor

Türkmen, Ş., Bäckström, T. C., Wahlström, G., Andréen, L., & Johansson, I. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01059.x · Cited by 97 · see citing works

Modeling sharp wave‐ripple complexes through a CA3‐CA1 network model with chemical synapses

Taxidis, J., Coombes, S., Mason, R., & Owen, M. (2012) · Hippocampus · doi:10.1002/hipo.20930 · Cited by 104 · see citing works

Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action

Colloc’h, N., Santos, J. S. O., Retailleau, P., Vivarès, D., Bonneté, F., d’Estaintot, B. L., Gallois, B., Brisson, A. R., Risso, J., Lemaire, M., et al. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.093807 · Cited by 95 · see citing works

GABAA Receptor M2–M3 Loop Secondary Structure and Changes in Accessibility during Channel Gating

Bera, A. K., Chatav, M., & Akabas, M. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206321200 · Cited by 95 · see citing works

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

Weng, Y., Yang, L., Corringer, P., & Sonner, J. M. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181c4bc69 · Cited by 94 · see citing works

The interaction of anaesthetic steroids with recombinant glycine and GABA A receptors †

Weir, C. J., Ling, A., Belelli, D., Wildsmith, J. A. W., Peters, J. A., & Lambert, J. J. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aeh125 · Cited by 90 · see citing works

Volatile Anesthetics Enhance Flash-induced γ Oscillations in Rat Visual Cortex

Imas, O. A., ROPELLA, K. M., Ward, B. D., Wood, J. D., & Hudetz, A. G. (2005) · Anesthesiology · doi:10.1097/00000542-200505000-00012 · Cited by 89 · see citing works

Mechanisms of general anesthesia: from molecules to mind

Mashour, G. A., Forman, S. A., & Campagna, J. A. (2005) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2005.01.004 · Cited by 84 · see citing works

Isoflurane inhibits the neurotransmitter release machinery

Herring, B. E., Xie, Z., Marks, J., & Fox, A. P. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00252.2009 · Cited by 83 · see citing works

A Predicted Binding Site for Cholesterol on the GABAA Receptor

Hénin, J., Salari, R., Murlidaran, S., & Brannigan, G. H. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.03.024 · Cited by 84 · see citing works

Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol

Zeller, A., Arras, M., Lazaris, A., Jurd, R., & Rudolph, U. (2005) · The FASEB Journal · doi:10.1096/fj.04-3443fje · Cited by 83 · see citing works

HCN Subunit-Specific and cAMP-Modulated Effects of Anesthetics on Neuronal Pacemaker Currents

Chen, X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1153-05.2005 · Cited by 81 · see citing works

Exploring Volatile General Anesthetic Binding to a Closed Membrane-Bound Bacterial Voltage-Gated Sodium Channel via Computation

Raju, S. G., Barber, A. F., LeBard, D. N., Klein, M. L., & Carnevale, V. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003090 · Cited by 79 · see citing works

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for [3H]Azietomidate, a Photoactivatable General Anesthetic

Ziebell, M. R., Nirthanan, S., Husain, S. S., Miller, K. W., & Cohen, J. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313886200 · Cited by 77 · see citing works

Glycine receptors and glycine transporters: targets for novel analgesics?

Zeilhofer, H. U., Acuña, M. A., Gingras, J., & Yévenes, G. E. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2622-x · Cited by 77 · see citing works

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J., & Lambert, J. J. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex369 · Cited by 78 · see citing works

Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature

Roussin, A., Montastruc, J., & Lapeyre‐Mestre, M. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00497.x · Cited by 76 · see citing works

Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital

Zeller, A., Arras, M., Jurd, R., & Rudolph, U. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030049 · Cited by 74 · see citing works

Neurons in the Ventral Spinal Cord Are More Depressed by Isoflurane, Halothane, and Propofol Than Are Neurons in the Dorsal Spinal Cord

Kim, J., Yao, A., Atherley, R. J., Carstens, E. E., Jinks, S. L., & Antognini, J. F. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000280483.17854.56 · Cited by 73 · see citing works

Partitioning of Anesthetics into a Lipid Bilayer and their Interaction with Membrane-Bound Peptide Bundles

Vemparala, S., Saiz, L., Eckenhoff, R. G., & Klein, M. L. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.085324 · Cited by 71 · see citing works

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

Belelli, D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00144-8 · Cited by 70 · see citing works

Mechanisms Involved in Cardiac Sensitization by Volatile Anesthetics: General Applicability to Halogenated Hydrocarbons?

Himmel, H. M. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440802237664 · Cited by 70 · see citing works

Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics

Lioudyno, M. I., Birch, A. M., Tanaka, B. S., Sokolov, Y., Goldin, A. L., Chandy, K. G., Hall, J. E., & Alkire, M. T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0344-13.2013 · Cited by 68 · see citing works

Anaesthetic Impairment of Immune Function Is Mediated via GABAA Receptors

Wheeler, D. W., Thompson, A. J., Corletto, F., Reckless, J., Loke, J. C. T., Lapaque, N., Grant, A. J., Mastroeni, P., Grainger, D. J., Padgett, C. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017152 · Cited by 69 · see citing works

Potentially Neuroprotective and Therapeutic Properties of Nitrous Oxide and Xenon

Abraini, J. H., David, H., & LEMAIRE, M. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb00036.x · Cited by 69 · see citing works

Altered temporal variance and neural synchronization of spontaneous brain activity in anesthesia

Huang, Z., Wang, Z., Zhang, J., Dai, R., Wu, J., Li, Y., Liang, W., Mao, Y. Q., Yang, Z. H., Holland, G., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22556 · Cited by 68 · see citing works

Breakdown in the temporal and spatial organization of spontaneous brain activity during general anesthesia

Zhang, J., Huang, Z., Chen, Y., Zhang, J., Ghinda, D., Nikolova, Y. S., Wu, J., Xu, J., Bai, W., Mao, Y. Q., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.23984 · Cited by 67 · see citing works

First Experimental Evidence of Dopamine Interactions with Negatively Charged Model Biomembranes

Jodko-Piórecka, K., & Litwinienko, G. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn4000633 · Cited by 66 · see citing works

A hypothesis on the origin and evolution of the response to inhaled anesthetics

Sonner, J. M. (2008) · Anesthesia &amp; Analgesia · doi:10.1213/ane.0b013e31817ee684 · Cited by 63 · see citing works

General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels

Kishikawa, J.-I., Inoue, Y., Fujikawa, M., Nishimura, K. J., Nakanishi, A., Tanabe, T., Imamura, H., & Yokoyama, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190213 · Cited by 65 · see citing works

Structural Evidence that Propofol Stabilizes Different GABAAReceptor States at Potentiating and Activating Concentrations

Williams, D. B., & Akabas, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07417.2002 · Cited by 65 · see citing works

Propofol-Induced Changes in Neurotrophic Signaling in the Developing Nervous System In Vivo

Popić, J., Pešić, V., Milanović, D., Todorovic, S. T., Kanazir, S., Jevtović‐Todorović, V., & Ruždijić, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034396 · Cited by 62 · see citing works

General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity

LeBard, D. N., Hénin, J., Eckenhoff, R. G., Klein, M. L., & Brannigan, G. H. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002532 · Cited by 63 · see citing works

GABA signaling in the nucleus tractus solitarius sets the level of activity in dorsal motor nucleus of the vagus cholinergic neurons in the vagovagal circuit

Herman, M. A., Cruz, M. T., Sahibzada, N., Verbalis, J. G., & Gillis, R. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90504.2008 · Cited by 64 · see citing works

The Actions of Propofol on γ-Aminobutyric Acid-A and Glycine Receptors in Acutely Dissociated Spinal Dorsal Horn Neurons of the Rat

Dong, X., & Xu, T. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200210000-00021 · Cited by 64 · see citing works

Modulation of a voltage-gated Na ⁺ channel by sevoflurane involves multiple sites and distinct mechanisms

Barber, A. F., Carnevale, V., Klein, M. L., Eckenhoff, R. G., & Covarrubias, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405768111 · Cited by 60 · see citing works

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of α1 glycine receptors

Crawford, D. K., Trudell, J. R., Bertaccini, E. J., Li, K., Davies, D. L., & Alkana, R. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04680.x · Cited by 63 · see citing works

Nitrous Oxide Decreases Cortical Methionine Synthase Transiently but Produces Lasting Memory Impairment in Aged Rats

Culley, D. J., Raghavan, S. V., Waly, M. I., Baxter, M. G., Yukhananov, R. Y., Deth, R. C., & Crosby, G. J. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000266491.53318.20 · Cited by 62 · see citing works

Compartmentation of alpha 1 and alpha 2 GABAA receptor subunits within rat extended amygdala: implications for benzodiazepine action

Kaufmann, W. A., Humpel, C., Alheid, G. F., & Marksteiner, J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04082-9 · Cited by 62 · see citing works

How Anesthetics, Neurotransmitters, and Antibiotics Influence the Relaxation Processes in Lipid Membranes

Seeger, H. M., Gudmundsson, M. L., & Heimburg, T. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp075346b · Cited by 60 · see citing works

General anesthesia mediated by effects on ion channels

Zhou, C. (2012) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v1.i3.80 · Cited by 61 · see citing works

Thermogenesis Inhibition in Brown Adipocytes Is a Specific Property of Volatile Anesthetics

Ohlson, K. B. E., Lindahl, S. G. E., Cannon, B., & Nedergaard, J. (2003) · Anesthesiology · doi:10.1097/00000542-200302000-00025 · Cited by 61 · see citing works

Pharmacological and Anatomical Evidence for an Interaction Between mGluR5- and GABAA α1-Containing Receptors in the Discriminative Stimulus Effects of Ethanol

Besheer, J., & Hodge, C. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300616 · Cited by 61 · see citing works

Tryptophan scanning mutagenesis in TM4 of the GABAA receptor α1 subunit: implications for modulation by inhaled anesthetics and ion channel structure

Jenkins, A., Andreasen, A., Trudell, J. R., & Harrison, N. L. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00175-2 · Cited by 60 · see citing works

Does the Immobilizing Effect of Thiopental in Brain Exceed That of Halothane?

Antognini, J. F., Carstens, E. E., & Atherley, R. J. (2002) · Anesthesiology · doi:10.1097/00000542-200204000-00028 · Cited by 60 · see citing works

A New Hypothesis for Alzheimer’s Disease: The Lipid Invasion Model

Rudge, J. D. (2022) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-210299 · Cited by 58 · see citing works

Identification of Two Mutations (F758W and F758Y) in the N -methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding

Armstrong, S. P., Banks, P. J., McKitrick, T. J. W., Geldart, C. H., Edge, C. J., Babla, R., Simillis, C., Franks, N. P., & Dickinson, R. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31825ada2e · Cited by 57 · see citing works

Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal

van Alst, T. M., Wachsmuth, L., Datunashvili, M., Albers, F., Just, N., Budde, T., & Faber, C. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.057 · Cited by 53 · see citing works

Anesthetics and Ion Channels: Molecular Models and Sites of Action

Yamakura, T., Bertaccini, E. J., Trudell, J. R., & Harris, R. A. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.23 · Cited by 245 · see citing works

Emerging molecular mechanisms of general anesthetic action

Hemmings, H. C., Akabas, M. H., Goldstein, P. A., Trudell, J. R., Orser, B. A., & Harrison, N. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.006 · Cited by 542 · see citing works

The effects of general anaesthetics on ligand-gated ion channels

Dilger, J. P. (2002) · British Journal of Anaesthesia · doi:10.1093/bja/aef161 · Cited by 90 · see citing works

Molecular and cellular mechanisms of general anaesthesia

Franks, N. P., & Lieb, W. R. (1994) · Nature · doi:10.1038/367607a0 · Cited by 1,786 · see citing works

General anaesthetic action at transmitter-gated inhibitory amino acid receptors

Belelli, D., Pistis, M., Peters, J. A., & Lambert, J. J. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01405-4 · Cited by 132 · see citing works