The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Selective Dysfunction of Hippocampal CA1 Astrocytes Contributes to Delayed Neuronal Damage after Transient Forebrain Ischemia
Open accessAbstract
Transient global ischemia, as with cardiac arrest, causes loss of CA1 hippocampal neurons 2–4 d later, whereas nearby dentate gyrus (DG) neurons are relatively resistant. Whether differential astrocyte vulnerability in ischemic injury contributes to CA1 neuronal death is uncertain. Here, we find that CA1 astrocytes are more sensitive to ischemia than DG astrocytes. In rats subjected to transient forebrain ischemia, CA1 astrocytes lose glutamate transport activity and immunoreactivity for GFAP, S100β, and glutamate transporter GLT-1 within a few hours of reperfusion, but without astrocyte cell death. Oxidative stress may contribute to the observed selective CA1 changes, because CA1 astrocytes show early increases in mitochondrial free radicals and reduced mitochondrial membrane potential. Similar changes were not observed in DG astrocytes. Upregulation of GLT-1 expression in astrocytes with ceftriaxone protected CA1 neurons from forebrain ischemia. We suggest that greater oxidative stress and loss of GLT-1 function selectively in CA1 astrocytes is central to the well known delayed death of CA1 neurons.
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Cited by
Selective neuronal vulnerability to oxidative stress in the brain
Wang (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00012 · Cited by 1,008
Pathogenic mechanisms following ischemic stroke
Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 621
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
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Astrocyte metabolism and signaling during brain ischemia
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Metadata
- Authors
- Ouyang, Y.-B., Voloboueva, L. A., Xu, L.-J., & Giffard, R. G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-04-18
- Volume
- 27
- Issue
- 16
- Pages
- 4253-4260
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2083759504
- Cited by
- 279
- References
- 52
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ouyang, Y.-B., Voloboueva, L. A., Xu, L.-J., & Giffard, R. G. (2007). Selective Dysfunction of Hippocampal CA1 Astrocytes Contributes to Delayed Neuronal Damage after Transient Forebrain Ischemia. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0211-07.2007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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