The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone
Open accessAbstract
Partial inhibition of mitochondrial respiratory complex I by rotenone reproduces aspects of Parkinson's disease in rodents. The hypothesis that rotenone enhancement of neuronal cell death is attributable to oxidative stress was tested in an acute glutamate excitotoxicity model using primary cultures of rat cerebellar granule neurons. As little as 5 n m rotenone increased mitochondrial superoxide (O 2·−) levels and potentiated glutamate-induced cytoplasmic Ca 2+deregulation, the first irreversible stage of necrotic cell death. However, the potent cell-permeant O 2·−trap manganese tetrakis (N-ethylpyridinium-2yl) porphyrin failed to prevent the effects of the inhibitor. The bioenergetic consequences of rotenone addition were quantified by monitoring cell respiration. Glutamate activation of NMDA receptors used the full respiratory capacity of the in situ mitochondria, and >80% of the glutamate-stimulated respiration was attributable to increased cellular ATP demand. Rotenone at 20 n m inhibited basal and carbonyl cyanide p-trifluoromethoxyphenylhydrazone-stimulated cell respiration and caused respiratory failure in the presence of glutamate. ATP synthase inhibition by oligomycin was also toxic in the presence of glutamate. We conclude that the cell vulnerability in the rotenone model of partial complex I deficiency under these specific conditions is primarily determined by spare respiratory capacity rather than oxidative stress.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Under increased workload, stress, or nutrient limitation, cells engage this reserve capacity to generate more energy and promote cell viability (14, 15).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770
Li, N., Ragheb, K., Lawler, G., Sturgis, J., Rajwa, B. P., Melendez, J. A., & Robinson, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210432200 · Cited by 1,465
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Self-citationNMDA-dependent superoxide production and neurotoxicity
Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183
Mitochondria and neuronal activity
Kann, O., & Kovács, R. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2006 · Cited by 871
Keeney, P. M., Xie, J., Capaldi, R., & Bennett, J. P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-06.2006 · Cited by 765
Schapira, A. H. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68970-8 · Cited by 617
Characterization of Superoxide-producing Sites in Isolated Brain Mitochondria
Kudin, A. P., Bimpong‐Buta, N., Vielhaber, S., Elger, C. E., & Kunz, W. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310341200 · Cited by 514
Budd, S. L., & Nicholls, D. G. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67062282.x · Cited by 435
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 272
AIF, reactive oxygen species, and neurodegeneration: A “complex” problem
Polster, B. M. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.002 · Cited by 59
Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice
Maeda, A., Palczewska, G., Golczak, M., Kohno, H., Dong, Z., Maeda, T., & Palczewski, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317986111 · Cited by 58
Schuh, R. A., Clerc, P., Hwang, H., Mehrabian, Z., Bittman, K. S., Chen, H., & Polster, B. M. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22650 · Cited by 57
Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function
Moosavi, B., Zhu, X., Yang, W., & Yang, G. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0264 · Cited by 60
Triclosan is a mitochondrial uncoupler in live zebrafish
Shim, J., Weatherly, L. M., Luc, R. H., Dorman, M. T., Neilson, A., Ng, R., Kim, C. H., Millard, P. J., & Gosse, J. A. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3311 · Cited by 56
Pyruvate antioxidant roles in human fibroblasts and embryonic stem cells
Ramos‐Ibeas, P., Barandalla, M., Colleoni, S., & Lazzari, G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-2942-z · Cited by 55
Mancini, Ö. K., Lora, M., Cuillerier, A., Shum‐Tim, D., Hamdy, R. C., Burelle, Y., Servant, M. J., Stochaj, U., & Colmegna, I. (2017) · Circulation Research · doi:10.1161/circresaha.117.311400 · Cited by 56
Plasma cells: You are what you eat
D’Souza, L. J., & Bhattacharya, D. (2019) · Immunological Reviews · doi:10.1111/imr.12732 · Cited by 58
Cantu, D., Fulton, R. E., Drechsel, D. A., & Patel, M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07290.x · Cited by 54
Zhao, Q., Wang, S., Li, Y., Wang, P., Li, S., Guo, Y., & Yao, R. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1321 · Cited by 54
Aravamudan, B., Thompson, M., Sieck, G. C., Vassallo, R., Pabelick, C. M., & Prakash, Y. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25508 · Cited by 52
Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S. R., Kaidery, N. A., SAUL, A. B., Kaddour‐Djebbar, I., Bollag, W. B., Thomas, B., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101199 · Cited by 53
The energy–redox axis in aging and age-related neurodegeneration☆
Yap, L.-P., Garcia, J., Han, D., & Cadenas, E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.015 · Cited by 56
Esteve-Rudd, J., Fernández‐Sánchez, L., Lax, P., de Juan, E., Martín‐Nieto, J., & Cuenca, N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.06.009 · Cited by 52
Fried, N. T., Moffat, C., Seifert, E. L., & Oshinsky, M. L. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00332.2013 · Cited by 50
Lee, W.-H., Higuchi, H., Ikeda, S., Macke, E. L., Takimoto, T., Pattnaik, B. R., Liu, C., Chu, L.-F., Siepka, S. M., Krentz, K. J., et al. (2016) · eLife · doi:10.7554/elife.19264 · Cited by 52
Metabolic Adaptation of the Small Intestine to Short- and Medium-Term High-Fat Diet Exposure
Clara, R., Schumacher, M., Ramachandran, D., Fedele, S., Krieger, J.-P., Langhans, W., & Mansouri, A. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25402 · Cited by 51
Nickens, K. P., Wikström, J. D., Shirihai, O. S., Patierno, S. R., & Ceryak, S. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.09.005 · Cited by 54
Agnihotri, S. K., Shen, R., Li, J., Gao, X., & Büeler, H. (2017) · The FASEB Journal · doi:10.1096/fj.201600960rr · Cited by 50
Castellano‐González, G., Jacobs, K. R., Don, E. K., Cole, N. J., Adams, S., Lim, C. K., Lovejoy, D. B., & Guillemin, G. J. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-9997-4 · Cited by 50
Rose, S., Wynne, R. A., Frye, R. E., Melnyk, S., & James, S. J. (2015) · Journal of Toxicology · doi:10.1155/2015/573701 · Cited by 46
Clerc, P., Young, C. A., Bordt, E. A., Grigore, A. M., Fiskum, G. M., & Polster, B. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079982 · Cited by 45
Shu, D. Y., Butcher, E. R., & Saint‐Geniez, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094701 · Cited by 47
Natural Compounds from Saffron and Bear Bile Prevent Vision Loss and Retinal Degeneration
Fernández‐Sánchez, L., Lax, P., Noailles, A., Jeréz, A. A., Maneu, V., & Cuenca, N. (2015) · Molecules · doi:10.3390/molecules200813875 · Cited by 43
Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption
Monroe, R. K., & Halvorsen, S. W. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.03.007 · Cited by 43
Quintana, D. D., Garcia, J. A., Anantula, Y., Rellick, S. L., Engler-Chiurazzi, E. B., Sarkar, S. N., Brown, C. M., & Simpkins, J. W. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190964 · Cited by 41
Mitochondrial Function and Reactive Oxygen/Nitrogen Species in Skeletal Muscle
Chen, M., Li, Y., Deng, S., Zhao, Y., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.826981 · Cited by 49
Weisová, P., Anilkumar, U., Ryan, C., Concannon, C. G., Prehn, J. H. M., & Ward, M. W. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.01.016 · Cited by 42
Gleichmann, M., Collis, L. P., Smith, P. J., & Mattson, M. P. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05997.x · Cited by 41
Prohibitin is a positive modulator of mitochondrial function in PC 12 cells under oxidative stress
Anderson, C. J., Kahl, A., Qian, L., Степанова, А., Starkov, A. A., Manfredi, G., Iadecola, C., & Zhou, P. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14472 · Cited by 40
Dhingra, R., & Kirshenbaum, L. A. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.310 · Cited by 39
Hwang, R., Wiemerslage, L., LaBreck, C. J., Khan, M. H., Kannan, K., Wang, X., Zhu, X., Lee, D., & Fridell, Y.-W. C. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.032 · Cited by 38
Mitra, S., Chakrabarti, N., Dutta, S., Ray, S., Bhattacharya, P., Sinha, P., & Bhattacharyya, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.052 · Cited by 36
Case, A. J., Roessner, C. T., Tian, J., & Zimmerman, M. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164609 · Cited by 38
Handlogten, M. W., Zhu, M., & Ahuja, S. (2018) · Biochemical Engineering Journal · doi:10.1016/j.bej.2018.01.031 · Cited by 38
Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice
Flynn, J. M., Choi, S. W., Day, N. U., Gerencser, A. A., Hubbard, A., & Melov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.030 · Cited by 37
Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes
Nanjireddy, P., Olejniczak, S. H., & Buxbaum, N. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1121565 · Cited by 39
Nicholls, D. G., Brand, M. D., & Gerencser, A. A. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9573-9 · Cited by 36
Self-citationSingh, S., Zhuo, M., Gorgun, F. M., & Englander, E. W. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.03.008 · Cited by 34
Forty years of Mitchell's proton circuit: From little grey books to little grey cells
Nicholls, D. G. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.014 · Cited by 35
Self-citationWu, Y., & Johnson, S. W. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.041 · Cited by 35
Bactenecin 7 peptide fragment as a tool for intracellular delivery of a phosphorescent oxygen sensor
Dmitriev, R. I., Ropiak, H. M., Yashunsky, D. V., Ponomarev, G. V., Zhdanov, A. V., & Papkovsky, D. B. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07872.x · Cited by 34
Stauch, K. L., Emanuel, K. M., Lamberty, B. G., Morsey, B., & Fox, H. S. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0573-5 · Cited by 33
To Eat or Not to Eat: Neuronal Metabolism, Mitophagy, and Parkinson's Disease
Gusdon, A. M., & Chu, C. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3763 · Cited by 34
de Moura, M. B., & Houten, B. V. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-739-6_40 · Cited by 34
Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer’s Mice
Djordjevic, J., Chowdhury, S. R., Snow, W. M., Pérez, C. I., Cadonic, C., Fernyhough, P., & Albensi, B. C. (2020) · Cells · doi:10.3390/cells9061541 · Cited by 36
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
Xu, P., Chang, J. C., Zhou, X., Wang, W., Bamkole, M. A., Wong, E., Bettayeb, K., Jiang, L.-L., Huang, T. Y., Luo, W., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202446 · Cited by 36
Orexin A attenuates palmitic acid-induced hypothalamic cell death
Duffy, C. M., Nixon, J. P., & Butterick, T. A. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.07.003 · Cited by 31
Stauch, K. L., Villeneuve, L. M., Purnell, P. R., Ottemann, B. M., Emanuel, K. M., & Fox, H. S. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600005 · Cited by 32
Hermes, G., Nagy, D., Waterson, M., Zsarnovszky, A., Varela, L., Hajós, M., & Horváth, T. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.002 · Cited by 31
Mitov, M. I., Harris, J. W., Alstott, M. C., Zaytseva, Y. Y., Evers, B. M., & Butterfield, D. A. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.046 · Cited by 32
Verma, M., Kipari, T. M. J., Zhang, Z., Man, T. Y., Forster, T., Homer, N. Z. M., Seckl, J. R., Holmes, M. C., & Chapman, K. E. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.015 · Cited by 31
Nicholls, D. G. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.018 · Cited by 30
Self-citationPharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction
Chen, Z., Dudek, J., Maack, C., & Hofmann, U. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114597 · Cited by 31
Mapping mitochondrial respiratory chain deficiencies by respirometry: Beyond the Mito Stress Test
Jaber, S. M., Yadava, N., & Polster, B. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113282 · Cited by 29
Self-citationMancini, G., Dias, C., Lourenço, C. F., Laranjinha, J. A. N., Bem, A. F. D., & Ledo, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210122 · Cited by 31
Sarin, M., Wang, Y., Zhang, F., Rothermund, K., Zhang, Y., Lu, J. L., Sims‐Lucas, S., Beer–Stolz, D., Houten, B. V., Vockley, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.201 · Cited by 30
Nicotine affects mitochondrial structure and function in human airway smooth muscle cells
Borkar, N. A., Thompson, M. A., Bartman, C. M., Sathish, V., Prakash, Y. S., & Pabelick, C. M. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00158.2023 · Cited by 28
Mitochondrial dysfunction and HIF1α stabilization in inflammation
Garedew, A., & Moncada, S. (2008) · Journal of Cell Science · doi:10.1242/jcs.034660 · Cited by 28
RetractedPereira, C. V., Oliveira, P. J., Will, Y., & Nadanaciva, S. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.030 · Cited by 28
Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function
Findlay, A. S., Carter, R. N., Starbuck, B., McKie, L., Nováková, K., Budd, P. S., Keighren, M., Marsh, J. A., Cross, S. H., Simon, M. M., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.036426 · Cited by 28
Wang, Z., Chan, S.-W., Zhao, H., Miu, K.-K., & Chan, W. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.406 · Cited by 28
Napoli, E., Ross‐Inta, C., Song, G., Wong, S., Hagerman, R. J., Gane, L. W., Smilowitz, J. T., Tassone, F., & Giulivi, C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00159 · Cited by 28
Melatonin Improves Mitochondrial Respiration in Syncytiotrophoblasts From Placentas of Obese Women
Ireland, K. E., Maloyan, A., & Myatt, L. (2017) · Reproductive Sciences · doi:10.1177/1933719117704908 · Cited by 27
Bell, S., Marco, M. D., Barnes, K., Shaw, P. J., Ferraiuolo, L., Blackburn, D. J., Mortiboys, H., & Venneri, A. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10020032 · Cited by 30
Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells
Diers, A. R., Broniowska, K. A., Darley-Usmar, V. M., & Hogg, N. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00210.2011 · Cited by 26
Rotenone reduces Mg2+-dependent block of NMDA currents in substantia nigra dopamine neurons
Wu, Y.-N., & Johnson, S. W. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.01.002 · Cited by 26
Edwards, G., Lee, Y., Kim, M., Bhanvadia, S., Keun-young Kim, A., & Ju, W. (2020) · Antioxidants · doi:10.3390/antiox9100952 · Cited by 25
Impaired Mitochondrial Metabolism and Mammary Carcinogenesis
Yadava, N., Schneider, S. S., Jerry, D. J., & Kim, C. G. (2012) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-012-9271-3 · Cited by 24
Self-citationFrye, R. E., Rose, S., Wynne, R. A., Bennuri, S. C., Blossom, S. J., Gilbert, K. M., Heilbrun, L. P., & Palmer, R. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-04821-3 · Cited by 25
Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen
Jones, T. T., & Brewer, G. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.09.011 · Cited by 25
Mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons
Wu, Y.-N., Munhall, A. C., & Johnson, S. W. (2011) · Brain Research · doi:10.1016/j.brainres.2011.04.032 · Cited by 24
Jones, T. T., & Brewer, G. J. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.009 · Cited by 25
Lehotský, J., Račay, P., Pavlíková, M., Tatarková, Z., Urban, P., Chomová, M., Kovalská, M., & Kaplán, P. (2009) · PubMed · Cited by 24
Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons
Kysenius, K., & Huttunen, H. J. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.01.001 · Cited by 24
Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations
Hoitzing, H., Gammage, P. A., Haute, L. V., Minczuk, M. A., Johnston, I. G., & Jones, N. S. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007023 · Cited by 24
Graves, J. A., Rothermund, K. D., Wang, T., Qian, W., Houten, B. V., & Prochownik, E. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013717 · Cited by 23
Zugno, A. I., Pacheco, F. D., Budni, J., de Oliveira, M. B., Canever, L., Heylmann, A. S., Wessler, P. G., Silveira, F. D. R., Mastella, G. A., Gonçalves, C. L., et al. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9671-3 · Cited by 23
Chang, S.-H., Hwang, C., Yin, J., Chen, S., & Yang, D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.014 · Cited by 22
Chemical Composition and In Vitro Neuroprotective Activity of Fibre-Type Cannabis sativa L. (Hemp)
Corsi, L., Pellati, F., Brighenti, V., Plessi, N., & Benvenuti, S. (2018) · Current Bioactive Compounds · doi:10.2174/1573407214666180809124952 · Cited by 22
Role ofp53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study
Wong, S., Napoli, E., Krakowiak, P., Tassone, F., Hertz‐Picciotto, I., & Giulivi, C. (2016) · PEDIATRICS · doi:10.1542/peds.2015-1888 · Cited by 23
Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells
Milam, A. A. V., Bartleson, J. M., Buck, M. D., Chang, C., Sergushichev, A., Donermeyer, D. L., Lam, W. Y., Pearce, E. L., Artyomov, M. N., & Allen, P. M. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000055 · Cited by 21
Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders
Allen, C. N. S., Arjona, S. P., Santerre, M., de Lucia, C., Koch, W. J., & Sawaya, B. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.812887 · Cited by 21
Reduced insulin signaling in neurons induces sex-specific health benefits
Baghdadi, M., Nespital, T., Mesaros, A., Buschbaum, S., Withers, D. J., Grönke, S., & Partridge, L. (2023) · Science Advances · doi:10.1126/sciadv.ade8137 · Cited by 24
Karmacharya, M. B., Hada, B., Park, S. R., & Choi, B. H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0104-z · Cited by 21
Zhou, Y., Al-Saaidi, R. A., Guerra, P. F., Freude, K., Olsen, R. K. J., Jensen, U. B., Gregersen, N., Hyttel, P., Bolund, L., Aagaard, L., et al. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0162 · Cited by 21
Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset
Gardiner, S. L., Milanese, C., Boogaard, M. W., Buijsen, R. A. M., Hogenboom, M., Roos, R. A. C., Mastroberardino, P. G., van Roon‐Mom, W., & Aziz, N. A. (2018) · Neurology Genetics · doi:10.1212/nxg.0000000000000275 · Cited by 20
Ma, H., Liu, Y., Tang, L., Ding, H., Bao, X., Song, F., Zhu, M., & Li, W. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.02.012 · Cited by 21
Armstrong, J. A., Cash, N. J., Morton, J. C., Tepikin, A. V., Sutton, R., & Criddle, D. N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071700 · Cited by 21
Baxter, K. K., Uittenbogaard, M. N., & Chiaramello, A. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.07.004 · Cited by 20
Singhal, N. S., Bai, M., Lee, E. M., Luo, S., Cook, K. R., & Dengke, K. (2020) · eLife · doi:10.7554/elife.55578 · Cited by 20
Jeon, Y. H., He, M., Austin, J., Shin, H., Pfleger, J. M., & Abdellatif, M. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109866 · Cited by 20
Boeck, C. R., Carbonera, L. S., Milioli, M. E., Constantino, L. C., Garcez, M. L., Rezin, G. T., Scaini, G., & STRECK, E. L. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1790-8 · Cited by 19
Literature-Related Discovery (LRD)
Kostoff, R. N., Block, J. A., Solka, J. L., Briggs, M. B., Rushenberg, R. L., Stump, J. A., Johnson, D., Lyons, T. J., & Wyatt, J. R. (2007) · Defense Technical Information Center (DTIC) · doi:10.21236/ada473438 · Cited by 19
Бакаева, З. В., Lizunova, N. V., Tarzhanov, I. A., Boyarkin, D., Petrichuk, S. V., Pinelis, V. G., Fisenko, А. P., Tuzikov, A. B., Sharipov, R. R., & Surin, A. M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.811171 · Cited by 18
Parkin as a Molecular Bridge Linking Alzheimer’s and Parkinson’s Diseases?
Checler, F., & da Costa, C. A. (2022) · Biomolecules · doi:10.3390/biom12040559 · Cited by 19
Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure
Wong, S., & Giulivi, C. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413122624 · Cited by 18
Villa, R. F., Ferrari, F., & Gorini, A. (2013) · Journal of Proteome Research · doi:10.1021/pr400834g · Cited by 18
Techniques to Investigate Neuronal Mitochondrial Function and its Pharmacological Modulation
Oliveira, J. M. A. (2011) · Current Drug Targets · doi:10.2174/138945011795528895 · Cited by 18
Michelini, L. G. B., Benevento, C. E., Rossato, F. A., Siqueira‐Santos, E. S., & Castilho, R. F. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1446-4 · Cited by 19
Metadata
- Authors
- Yadava, N., & Nicholls, D. G.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Nicholls, David G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-07-04
- Volume
- 27
- Issue
- 27
- Pages
- 7310-7317
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6794596
- OpenAlex
- W2061113435
- Cited by
- 272
- References
- 39
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 14 · 2021: 11 · 2020: 23 · 2019: 15 · 2018: 17 · 2017: 22 · 2016: 22 · 2015: 15 · 2014: 15 · 2013: 17 · 2012: 24
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01 AG2 1440, R01AG021440)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- rotenone, mitochondrial complex I deficiency, Parkinson's disease model, glutamate excitotoxicity, oxidative stress, spare respiratory capacity, mitochondrial superoxide, manganese porphyrin, necrosis, NMDA receptor, ATP demand, mitochondrial respiration, oligomycin, ATP synthase inhibition, cerebellar granule cells
- MeSH terms
- Animals, Mitochondria, Rotenone, Cell Death, Rats, Wistar, Oxidative Stress, Excitatory Amino Acid Agonists, Glutamic Acid, Cell Respiration, Electron Transport Complex I, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review