The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia
Open accessAbstract
In the present study, we show a biphasic activation of hypoxia inducible factor 1alpha (HIF-1) after stroke that lasts for up to 10 d, suggesting the involvement of the HIF pathway in several aspects of the pathophysiology of cerebral ischemia. We provide evidence that HIF-1-mediated responses have an overall beneficial role in the ischemic brain as indicated by increased tissue damage and reduced survival rate of mice with neuron-specific knockdown of HIF-1alpha that were subjected to transient focal cerebral ischemia. In addition, we demonstrated that drugs known to activate HIF-1 in cultured cells as well as in vivo had neuroprotective properties in this model of cerebral ischemia. This protective effect was significantly attenuated but not completely abolished in neuron-specific HIF-1alpha-deficient mice, suggesting that alternative mechanisms of neuroprotection are also implicated. Last, our study showed that hypoxia-induced tolerance to ischemia was preserved in neuron-specific HIF-1alpha-deficient mice, indicating that the neuroprotective effects of hypoxic preconditioning do not depend on neuronal HIF-1 activation.
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Cites
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“…is expressed, but it is rapidly hydroxylated at two conserved proline residues; this oxygen-dependent posttranslational modification is catalyzed by the EGLN [egl nine homolog 1 (C. elegans)] family of HIF prolyl hydroxylases (Bruick and McKnight, 2001; Ivan et al., 2001; Jaakkola et al., 2001).”
BackgroundBederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Cerebral preconditioning and ischaemic tolerance
Gidday, J. M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1927 · Cited by 751
Marti, H. J. H., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., & Risau, W. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64964-4 · Cited by 680
Demougeot, C., Van Hoecke, M., Bertrand, N., Prigent-Tessier, A., Mossiat, C., Beley, A., & Marie, C. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.072744 · Cited by 73
Cited by
Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Dirnagl, U., Becker, K., & Meisel, A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70054-7 · Cited by 587
O2 regulates stem cells through Wnt/β-catenin signalling
Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., & Simon, M. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2102 · Cited by 454
Self-citationPI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)
Zhang, Z., Yao, L., Yang, J., Wang, Z., & Du, G. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9375 · Cited by 404
NF-κB signaling in cerebral ischemia
Ridder, D. A., & Schwaninger, M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.007 · Cited by 386
Metadata
- Authors
- Baranova, O., Miranda, L. F., Pichiule, P., Dragatsis, I., Johnson, R. S., & Chavez, J. C.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-06
- Volume
- 27
- Issue
- 23
- Pages
- 6320-6332
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2027052432
- Cited by
- 350
- References
- 8
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia. https://app.cochat.ai/papers/10.1523/jneurosci.0449-07.2007
- The paper
- Baranova, O., Miranda, L. F., Pichiule, P., Dragatsis, I., Johnson, R. S., & Chavez, J. C. (2007). Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0449-07.2007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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