The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)
Open accessAbstract
Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and mortality. Previous studies have demonstrated that the phosphatidylinositol‑3 kinase (PI3K)/protein kinase B (Akt) signaling pathway, which regulates a wide range of cellular functions, is involved in the resistance response to H‑I through the activation of proteins associated with survival and inactivation of apoptosis‑associated proteins. It can also regulate the expression of hypoxia‑induced factor‑1α (HIF‑1α). HIF‑1α can further regulate the expression of downstream proteins involved in glucose metabolism and angiogenesis, such as vascular endothelial growth factor and erythropoietin, to facilitate ischemic adaptation. Notably, HIF‑1α may also induce detrimental effects. The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating diseases accompanied by H‑I.
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Cites
1 retracted
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601
RetractedThe phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
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“One of the potent stimuli for increased VEGF production is hypoxia (71).”
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
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Cited by
Hypoxia and the phenomenon of immune exclusion
Pietrobon, V., & Marincola, F. M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02667-4 · Cited by 119
TRAP1 in Oxidative Stress and Neurodegeneration
Ramos Rego, I., Santos Cruz, B., Ambrósio, A. F., & Alves, C. H. (2021) · Antioxidants · doi:10.3390/antiox10111829 · Cited by 44
Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment
Lappano, R., Todd, L. A., Stanic, M., Cai, Q., Maggiolini, M., Marincola, F., & Pietrobon, V. (2022) · Cancers · doi:10.3390/cancers14030539 · Cited by 32
Multiple Faces of the Glioblastoma Microenvironment
Șovrea, A. S., Boșca, B., Melincovici, C. S., Constantin, A.-M., Crintea, A., Mărginean, M., Dronca, E., Jianu, M. E., Suflețel, R., Gonciar, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020595 · Cited by 26
Walecha, V., & Luthra, P. M. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04559-9 · Cited by 12
Metadata
- Authors
- Zhang, Z., Yao, L., Yang, J., Wang, Z., & Du, G.
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2018-08-09
- Volume
- 18
- Issue
- 4
- Pages
- 3547-3554
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- OpenAlex
- W2885551446
- Cited by
- 404
- References
- 90
- FWCI
- 27.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhang, Z., Yao, L., Yang, J., Wang, Z., & Du, G. (2018). PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review). Molecular Medicine Reports. https://doi.org/10.3892/mmr.2018.9375
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