The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Transient Receptor Potential Vanilloid 1 Is Required for Intrinsic Osmoreception in Organum Vasculosum Lamina Terminalis Neurons and for Normal Thirst Responses to Systemic Hyperosmolality
Open accessAbstract
Recent studies have indicated that members of the transient receptor potential vanilloid (TRPV) family of cation channels are required for the generation of normal osmoregulatory responses, yet the mechanism of osmosensory transduction in primary osmoreceptor neurons of the CNS remains to be defined. Indeed, despite ample evidence suggesting that the organum vasculosum lamina terminalis (OVLT) serves as the primary locus of the brain for the detection of osmotic stimuli, evidence that neurons in the OVLT are intrinsically osmosensitive has remained elusive. Here we show that murine OVLT neurons are intrinsically sensitive to increases in the osmolality of the extracellular fluid. Hypertonic conditions provoked increases in membrane cation conductance that resulted in the generation of an inward current, depolarizing osmoreceptor potentials, and enhanced action potential discharge. Moreover, we found that this osmosensory signal transduction cascade was absent in OVLT neurons from TRPV1 knock-out ( TRPV1 −/− ) mice and that responses of wild type (WT) OVLT neurons could be blocked by ruthenium red, an inhibitor of TRPV channels. Finally, TRPV1 −/− mice showed significantly attenuated water intake in response to systemic hypertonicity compared with WT controls. These findings indicate that OVLT neurons act as primary osmoreceptors and that a product of the trpv1 gene is required for osmosensory transduction.
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Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
Watanabe, H., Vriens, J., Prenen, J., Droogmans, G., Voets, T., & Nilius, B. (2003) · Nature · doi:10.1038/nature01807 · Cited by 1,027
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G., & Plant, T. D. (2000) · Nature Cell Biology · doi:10.1038/35036318 · Cited by 1,023
Abnormal osmotic regulation in trpv4 -/- mice
Liedtke, W., & Friedman, J. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735416100 · Cited by 797
TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes
Muraki, K., Iwata, Y., Katanosaka, Y., Ito, T., Ohya, S., Shigekawa, M., & Imaizumi, Y. (2003) · Circulation Research · doi:10.1161/01.res.0000097263.10220.0c · Cited by 521
Sensory circumventricular organs and brain homeostatic pathways
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Impaired osmotic sensation in mice lacking TRPV4
Mizuno, A., Matsumoto, N., Imai, M., & Suzuki, M. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00559.2002 · Cited by 378
Osmoreceptors, Osmoreception, and Osmoregulation
Bourque, C. W., Oliet, S. H. R., & Richard, D. (1994) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1994.1010 · Cited by 342
Self-citationThe mechanosensitive nature of TRPV channels
O‘Neil, R. G., & Heller, S. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1424-4 · Cited by 337
Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Clinical practice guideline on diagnosis and treatment of hyponatraemia
Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D., Decaux, G., Fenske, W., Hoorn, E., Ichai, C., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3210-2 · Cited by 1,020
Clinical practice guideline on diagnosis and treatment of hyponatraemia
Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D., Decaux, G., Fenske, W., Hoorn, E. J., Ichai, C., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-1020 · Cited by 855
Central mechanisms of osmosensation and systemic osmoregulation
Bourque, C. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2400 · Cited by 718
Self-citationClinical practice guideline on diagnosis and treatment of hyponatraemia
Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D., Decaux, G., Fenske, W., Hoorn, E. J., Ichai, C., et al. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu040 · Cited by 579
Metadata
- Authors
- Ciura, S., & Bourque, C. W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-08-30
- Volume
- 26
- Issue
- 35
- Pages
- 9069-9075
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1971066362
- Cited by
- 277
- References
- 40
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ciura, S., & Bourque, C. W. (2006). Transient Receptor Potential Vanilloid 1 Is Required for Intrinsic Osmoreception in Organum Vasculosum Lamina Terminalis Neurons and for Normal Thirst Responses to Systemic Hyperosmolality. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0877-06.2006
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