The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Retinal Ganglion Cells with Distinct Directional Preferences Differ in Molecular Identity, Structure, and Central Projections
Open accessAbstract
The retina contains ganglion cells (RGCs) that respond selectively to objects moving in particular directions. Individual members of a group of ON-OFF direction-selective RGCs (ooDSGCs) detect stimuli moving in one of four directions: ventral, dorsal, nasal, or temporal. Despite this physiological diversity, little is known about subtype-specific differences in structure, molecular identity, and projections. To seek such differences, we characterized mouse transgenic lines that selectively mark ooDSGCs preferring ventral or nasal motion as well as a line that marks both ventral- and dorsal-preferring subsets. We then used the lines to identify cell surface molecules, including Cadherin 6, CollagenXXVα1, and Matrix metalloprotease 17, that are selectively expressed by distinct subsets of ooDSGCs. We also identify a neuropeptide, CART (cocaine- and amphetamine-regulated transcript), that distinguishes all ooDSGCs from other RGCs. Together, this panel of endogenous and transgenic markers distinguishes the four ooDSGC subsets. Patterns of molecular diversification occur before eye opening and are therefore experience independent. They may help to explain how the four subsets obtain distinct inputs. We also demonstrate differences among subsets in their dendritic patterns within the retina and their axonal projections to the brain. Differences in projections indicate that information about motion in different directions is sent to different destinations.
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Self-citationThe mechanism of directionally selective units in rabbit's retina.
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Self-citationDirection selectivity in the retina: symmetry and asymmetry in structure and function
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The most numerous ganglion cell type of the mouse retina is a selective feature detector
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Metadata
- Authors
- Kay, J. N., De la Huerta, I., Kim, I.-J., Zhang, Y., Yamagata, M., Chu, M. W., Meister, M., & Sanes, J. R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-05-25
- Volume
- 31
- Issue
- 21
- Pages
- 7753-7762
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1972182447
- Cited by
- 349
- References
- 44
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kay, J. N., De la Huerta, I., Kim, I.-J., Zhang, Y., Yamagata, M., Chu, M. W., Meister, M., & Sanes, J. R. (2011). Retinal Ganglion Cells with Distinct Directional Preferences Differ in Molecular Identity, Structure, and Central Projections. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0907-11.2011
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