The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Dual Control of Dopamine Synthesis and Release by Presynaptic and Postsynaptic Dopamine D2 Receptors
Open accessAbstract
Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (DA) levels are causally linked to Parkinson's disease, schizophrenia, and addiction. Major sites of DA synthesis are the mesencephalic neurons originating in the substantia nigra and ventral tegmental area; these structures send major projections to the dorsal striatum (DSt) and nucleus accumbens (NAcc), respectively. DA finely tunes its own synthesis and release by activating DA D2 receptors (D2R). To date, this critical D2R-dependent function was thought to be solely due to activation of D2Rs on dopaminergic neurons (D2 autoreceptors); instead, using site-specific D2R knock-out mice, we uncover that D2 heteroreceptors located on non-DAergic medium spiny neurons participate in the control of DA levels. This D2 heteroreceptor-mediated mechanism is more efficient in the DSt than in NAcc, indicating that D2R signaling differentially regulates mesolimbic- versus nigrostriatal-mediated functions. This study reveals previously unappreciated control of DA signaling, shedding new light on region-specific regulation of DA-mediated effects.
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Cites
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
Lammel, S., Ion, D. I., Roeper, J., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.025 · Cited by 766
Distinct functions of the two isoforms of dopamine D2 receptors
Usiello, A., Baik, J.-H., Rougé-Pont, F., Picetti, R., Dierich, A., LeMeur, M., Piazza, P. V., & Borrelli, E. (2000) · Nature · doi:10.1038/35041572 · Cited by 717
Self-citationControls of tonic and phasic dopamine transmission in the dorsal and ventral striatum
Zhang, L., Doyon, W. M., Clark, J. J., Phillips, P. E. M., & Dani, J. A. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056317 · Cited by 161
Kapfhamer, D., Berger, K. H., Hopf, F. W., Seif, T., Kharazia, V., Bonci, A., & Heberlein, U. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1292-10.2010 · Cited by 71
Self-citationPhasic Dopamine Signaling During Behavior, Reward, and Disease States
Wightman, R., & Heien, M. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706784111605 · Cited by 68 · cited 1×
“We then compared the effects D2 autoreceptors and heteroreceptors deletion on evoked DA overflow by performing CV in acute brain slices of DSt (Heien and Wightman, 2006).”
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Cited by
Dopamine reward prediction-error signalling: A two-component response
Schultz, W. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.26 · Cited by 1,036
Dopamine receptors –IUPHAR R eview 13
Beaulieu, J., Espinoza, S., & Gainetdinov, R. R. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12906 · Cited by 521
Striatal dopamine neurotransmission: Regulation of release and uptake
Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382
Self-citationFelger, J. C., Mun, J., Kimmel, H. L., Nye, J. A., Drake, D. F., Hernandez, C. R., Freeman, A. A., Rye, D. B., Goodman, M. M., Howell, L. L., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.115 · Cited by 214
Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons
Barik, J., Marti, F., Morel, C., Fernandez, S. P., Lanteri, C., Godeheu, G., Tassin, J.-P., Mombereau, C., Faure, P., & Tronche, F. (2013) · Science · doi:10.1126/science.1226767 · Cited by 214
Metadata
- Authors
- Anzalone, A., Lizardi-Ortiz, J. E., Ramos, M., De Mei, C., Hopf, F. W., Iaccarino, C., Halbout, B., Jacobsen, J., Kinoshita, C., Welter, M., Caron, M. G., Bonci, A., Sulzer, D., & Borrelli, E.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-06-27
- Volume
- 32
- Issue
- 26
- Pages
- 9023-9034
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2095738503
- Cited by
- 201
- References
- 6
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Anzalone, A., Lizardi-Ortiz, J. E., Ramos, M., De Mei, C., Hopf, F. W., Iaccarino, C., Halbout, B., Jacobsen, J., Kinoshita, C., Welter, M., Caron, M. G., Bonci, A., Sulzer, D., & Borrelli, E. (2012). Dual Control of Dopamine Synthesis and Release by Presynaptic and Postsynaptic Dopamine D2 Receptors. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0918-12.2012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
