The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons
Open accessAbstract
We examined the postnatal consequences of removing Hedgehog signaling within the adult stem cell niche. Although at birth the subventricular zone appears normal in mice lacking Hedgehog signaling, by postnatal day 8 it is greatly impaired, and cell death is increased. In addition, both the quiescent B stem cell population and transit-amplifying C cells become depleted postnatally. In contrast, the A cell population expands precociously, mostly fails to migrate to the olfactory bulbs, and is ultimately also depleted by postnatal day 30.In vitro and in vivo analyses demonstrate that this failure in migration is a result of nonautonomous signaling, possibly caused by a reduction in Slit1 ligand in A cells. These results suggest that Hedgehog signaling is required for the maintenance of the B and C cell populations and indirectly for the migration of the neurons that are generated from the adult stem cell niche.
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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Vertebrate Smoothened functions at the primary cilium
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Cilia and Hedgehog responsiveness in the mouse
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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
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Self-citation
Cited by
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381
“We did not detect any EYFP+ CFU-F colonies formed by bone marrow cells from Nestin-creER; loxp-EYFP mice (Figure 2A).”
InfluentialImayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4987-09.2010 · Cited by 716
Yang, Z.-J., Ellis, T., Markant, S. L., Read, T.-A., Kessler, J. D., Bourboulas, M., Schüller, U., Machold, R., Fishell, G., Rowitch, D. H., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.003 · Cited by 698
Self-citationNeurogenesis in the embryonic and adult brain: same regulators, different roles
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Metadata
- Authors
- Balordi, F., & Fishell, G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-05-30
- Volume
- 27
- Issue
- 22
- Pages
- 5936-5947
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1992803636
- Cited by
- 171
- References
- 8
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Balordi, F., & Fishell, G. (2007). Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1040-07.2007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
