The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures
Open accessAbstract
First described as a survival factor for chick ciliary ganglion neurons, ciliary neurotrophic factor (CNTF) has recently been shown to promote survival of chick embryo motor neurons. We now report neurotrophic effects of CNTF toward three populations of rat hippocampal neurons, the first demonstration of effects of CNTF upon rodent CNS neurons in culture. CNTF elicited an increase in the neurofilament content of hippocampal cultures prepared from embryonic day 18 (E18) rat brain. This was accompanied by increases of 2-, 28-, and 3-fold in the number of GABAergic, cholinergic, and calbindin- immunopositive cells, respectively. CNTF totally prevented the 67% loss of GABAergic neurons that occurred in control cultures over 8 d. CNTF also increased high-affinity GABA uptake and glutamic acid decarboxylase activity. Effects of CNTF were in all cases dose dependent, with maximal stimulation at approximately 100 pg/ml. When addition was delayed for 3 d, CNTF failed to elicit increases either in the number of cholinergic neurons or in GABA uptake.
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Citations
Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110
Cited by
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Neurotrophic factors: from molecule to man
Lindsay, R. M., Wiegand, S. J., Anthony Altar, C., & DiStefano, P. S. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90099-x · Cited by 788
Self-citationLaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D., & Steinberg, R. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11249 · Cited by 719
Ip, N. Y., Nye, S. H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S. J., Yasukawa, K., Kishimoto, T., Anderson, D. J., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90634-o · Cited by 684
Self-citationDisruption of the CNTF gene results in motor neuron degeneration
Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G., & Thoenen, H. (1993) · Nature · doi:10.1038/365027a0 · Cited by 558
Metadata
- Authors
- Ip, N., Li, Y., van de Stadt, I., Panayotatos, N., Alderson, R., & Lindsay, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1991-10-01
- Volume
- 11
- Issue
- 10
- Pages
- 3124-3134
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2121430610
- Cited by
- 188
- References
- 3
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ip, N., Li, Y., van de Stadt, I., Panayotatos, N., Alderson, R., & Lindsay, R. (1991). Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.11-10-03124.1991
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