The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb
Open accessAbstract
In mammals, the olfactory bulb (OB) constitutes one of two regions of the postnatal brain with continuous neurogenesis throughout life. Despite intense explorations of neuronal replacement in the adult OB, little is known about the mechanisms that operate at earlier postnatal stages. This question is particularly pertinent, because the majority of local interneurons are born in the neonate, when olfaction controls vital functions. Here, we analyzed the recruitment of newborn cells to the granule cell (GC) layer (GCL) and found that the postnatal mouse OB is supplied with two spatiotemporally distinct populations of newborn interneurons. Early born [postnatal day 3 (P3) to P7] GCs constitute a threefold larger population compared with those generated later (P14-P60), and some of them are produced locally within the OB itself. Newborn interneurons generated at P3-P7 were predominantly targeted to the external edge of the GCL, whereas newly generated cells were positioned deeper in older mice. Additionally, although approximately 50% of adult newborn cells were eliminated within a few weeks of reaching the OB, almost the entire population of early born GCs survived until adulthood. Importantly, early olfactory experience specifically modifies the number of newborn GCs in neonates but leaves unaltered the amount of neurons generated during adulthood. Together, these results demonstrate that early postnatal neurogenesis endows the neonate bulbar circuit with newborn GCs that differ morphologically and functionally from those produced in the adult.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“we argue that in our experimental conditions, most of the transduced GCs present in the adult OB originate from the early postnatal period, as this stage is concerned by a proliferation 3-fold larger than in adulthood, and producing GCs with very low cell death if any [14,20,21,55].”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [14]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“neonatal-born GCs have been primarily associated with innate olfactory responses [14,20,21,53,54].”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [14]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
Luskin, M. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90281-u · Cited by 1,803
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,511
Altman, J. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901370404 · Cited by 1,489
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,317
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F. K., Petreanu, L., Caillé, I., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,048
Altman, J., & Das, G. D. (1966) · The Journal of Comparative Neurology · doi:10.1002/cne.901260302 · Cited by 921
Becoming a new neuron in the adult olfactory bulb
Carleton, A., Petreanu, L., Lansford, R. D., Álvarez-Buylla, A., & Lledo, P. (2003) · Nature Neuroscience · doi:10.1038/nn1048 · Cited by 837
Self-citationRochefort, C., Gheusi, G., Vincent, J., & Lledo, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02679.2002 · Cited by 705
Self-citationMaturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction
Petreanu, L., & Álvarez-Buylla, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06106.2002 · Cited by 680
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
Palma, V., Lim, D. A., Dahmane, N., Sánchez‐Gómez, P., Brionne, T. C., Herzberg, C. D., Gitton, Y., Carleton, A., Álvarez-Buylla, A., & Altaba, A. R. I. (2004) · Development · doi:10.1242/dev.01567 · Cited by 610
Enwere, E. K., Shingo, T., Gregg, C., Fujikawa, H., Ohta, S., & Weiss, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2751-04.2004 · Cited by 549
Hinds, J. W. (1968) · The Journal of Comparative Neurology · doi:10.1002/cne.901340304 · Cited by 541
Extraction of spots in biological images using multiscale products
Olivo‐Marín, J. (2002) · Pattern Recognition · doi:10.1016/s0031-3203(01)00127-3 · Cited by 540
Biebl, M., Cooper, C., Winkler, J., & Kuhn, H. G. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01368-9 · Cited by 523
3H-thymidine-radiographic studies of neurogenesis in the rat olfactory bulb
Bayer, S. A. (1983) · Experimental Brain Research · doi:10.1007/bf00239197 · Cited by 503
Importance of newly generated neurons in the adult olfactory bulb for odor discrimination
Gheusi, G., Cremer, H., McLean, H., Chazal, G., Vincent, J., & Lledo, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1823 · Cited by 495
Self-citationLong‐term survival and cell death of newly generated neurons in the adult rat olfactory bulb
Winner, B., Cooper‐Kuhn, C. M., Aigner, R., Winkler, J., & Kuhn, H. G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02238.x · Cited by 439
Multipotent Neural Stem Cells Reside into the Rostral Extension and Olfactory Bulb of Adult Rodents
Gritti, A., Bonfanti, L., Doetsch, F. K., Caillé, I., Álvarez-Buylla, A., Lim, D. A., Galli, R., García‐Verdugo, J. M., Herrera, D. G., & Vescovi, A. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00437.2002 · Cited by 415
Electrophysiological Differentiation of New Neurons in the Olfactory Bulb
Belluzzi, O., Benedusi, M., Ackman, J. B., & LoTurco, J. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10411.2003 · Cited by 323
Membrane and synaptic properties of identified neurons in the olfactory bulb
Mori, K. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90024-4 · Cited by 320
GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone
Bolteus, A. J., & Bordey, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1999-04.2004 · Cited by 319
Lagier, S., Carleton, A., & Lledo, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5570-03.2004 · Cited by 267
Self-citationDendritic and axonal organization of mitral and tufted cells in the rat olfactory bulb
Orona, E., Rainer, E. C., & Scott, J. W. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902260305 · Cited by 253
Glial Tubes in the Rostral Migratory Stream of the Adult Rat
Peretto, P., Merighi, A., Fasolo, A., & Bonfanti, L. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00116-5 · Cited by 251
Adult neuron survival strategies — slamming on the brakes
Benn, S. C., & Woolf, C. J. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1477 · Cited by 251
Murase, S., & Horwitz, A. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03568.2002 · Cited by 245
Scott, J. W., McBride, R. L., & Schneider, S. P. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940304 · Cited by 234
Peretto, P. M., Merighi, A., Fasolo, A., & Bonfanti, L. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00037-4 · Cited by 218
Population dynamics of adult‐formed granule neurons of the rat olfactory bulb
Kaplan, M., McNelly, N. A. F., & Hinds, J. W. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902390110 · Cited by 209
Mitral and Tufted Cells Differ in the Decoding Manner of Odor Maps in the Rat Olfactory Bulb
Nagayama, S., Takahashi, Y. K., Yoshihara, Y., & Mori, K. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01266.2003 · Cited by 204
Laminar distributions of interneurons in the main olfactory bulb of the adult hamster
Schneider, S. P., & Macrides, F. (1978) · Brain Research Bulletin · doi:10.1016/0361-9230(78)90063-1 · Cited by 199
Orona, E., Scott, J. W., & Rainer, E. C. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902170209 · Cited by 173
Mason, H. A., Ito, S., & Corfas, G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07654.2001 · Cited by 161
Betarbet, R. S., Zigova, T., Bakay, R. A. E., & Luskin, M. B. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(96)00066-4 · Cited by 143
Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis)
Skeen, L. C., & Hall, W. C. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901720102 · Cited by 143
Schoenfeld, T. A., & Macrides, F. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902270113 · Cited by 116
Olfactory experience modulates apoptosis in the developing olfactory bulb
Najbauer, J., & Leon, M. (1995) · Brain Research · doi:10.1016/0006-8993(94)01448-q · Cited by 113
Frazier-Cierpial, L. L., & Brunjes, P. C. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902890312 · Cited by 110
The postnatal development of the main olfactory bulb of the rat.
Rosselli-Austin, L., & Altman, J. (1979) · PubMed · Cited by 110
Macrides, F., Schoenfeld, T. A., Marchand, J. E., & Clancy, A. N. (1985) · Chemical Senses · doi:10.1093/chemse/10.2.175 · Cited by 109
Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb
Mechawar, N., Saghatelyan, A., Grailhe, R., Scoriels, L., Gheusi, G., Gabellec, M.-M., Lledo, P.-M., & Changeux, J.-P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403361101 · Cited by 104
Self-citationComparative study of aging in the mouse olfactory bulb
Mirich, J. M., Williams, N. C., Berlau, D. J., & Brunjes, P. C. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10426 · Cited by 95
Phenotypic Differentiation during Migration of Dopaminergic Progenitor Cells to the Olfactory Bulb
Baker, H. A., Liu, N., Chun, H. S., Saino‐Saito, S., Berlin, R., Volpe, B. T., & Son, J. H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08505.2001 · Cited by 94
Olfactory processing in a changing brain
Lledo, P., & Gheusi, G. (2003) · Neuroreport · doi:10.1097/00001756-200309150-00001 · Cited by 82
Self-citationKishi, K., Mori, K., & Ojima, H. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902250404 · Cited by 79
Prenatal development of the rodent rostral migratory stream
Pencea, V., & Luskin, M. B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10746 · Cited by 76
Cell Death in Cortical Development: How Much? Why? So What?
Voyvodic, J. T. (1996) · Neuron · doi:10.1016/s0896-6273(00)80089-6 · Cited by 74
Woo, C. C., & Leon, M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903050106 · Cited by 55
Shah, A. A., Oxley, G., Lovic, V., & Fleming, A. S. (2002) · Developmental Psychobiology · doi:10.1002/dev.10064 · Cited by 40
Local neurons play key roles in the mammalian olfactory bulb
Saghatelyan, A., Carleton, A., Lagier, S., de Chevigny, A., & Lledo, P. (2003) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2004.01.009 · Cited by 30
Self-citationRodríguez-Echandía, E. L., Fóscolo, M. R., & Broitman, S. T. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90364-x · Cited by 19
Internucleosomal DNA fragmentation during deprived and non-deprived olfactory development
Najbauer, J., Yan, X., & Leon, M. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03313-3 · Cited by 10
Research works printed but not linked: 2
- 1983, Exp Brain Res, 50, 329
- 1979, J Dev Physiol, 1, 295
Cited by
Sorted by citations
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,425
Self-citationRoles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
Lagace, D. C., Whitman, M. C., Noonan, M. A., Ables, J. L., DeCarolis, N. A., Arguello, A. A., Donovan, M. H., Fischer, S. J., Farnbauch, L. A., Beech, R. D., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3812-07.2007 · Cited by 502
Origin and function of olfactory bulb interneuron diversity
Lledo, P., Merkle, F. T., & Álvarez-Buylla, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.05.006 · Cited by 440
Self-citationNeuronal organization of olfactory bulb circuits
Nagayama, S., Homma, R., & Imamura, F. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00098 · Cited by 411
Metadata
- Authors
- Lemasson, M., Saghatelyan, A., Olivo-Marin, J.-C., & Lledo, P.-M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-07-20
- Volume
- 25
- Issue
- 29
- Pages
- 6816-6825
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725349
- OpenAlex
- W2031228451
- Cited by
- 218
- References
- 55
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 14 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 3 · 2014: 16 · 2013: 20 · 2012: 10
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- olfactory bulb, postnatal neurogenesis, adult neurogenesis, granule cells, olfactory experience, neuronal survival, cell elimination
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Cell Division, Cell Movement, Interneurons, Male, Mice, Inbred C57BL, Neurons, Olfactory Bulb, Olfactory Pathways, Apoptosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
