Learning and survival of newly generated neurons: when time matters
Open accessAbstract
New interneurons are continually added to the olfactory bulb (OB), the first central relay for processing olfactory information, throughout life. It remains unknown how these adult-generated interneurons integrate into preexisting networks or die. We used immunohistochemical approaches to quantify adult neurogenesis in mice subjected to olfactory training. We identified a critical period in the life of an adult-generated OB interneuron, during which learning triggers distinct consequences. Using a discrimination learning task performed at various times after the birth of new interneurons, we found that olfactory training could increase, decrease, or have no effect on the number of surviving newly generated neurons. Cell survival and elimination depend on both the age of the cell and its location within the granule cell layer. This study provides new insight into the contribution of the newly generated interneurons to OB function. It demonstrates that neuronal elimination is an active process, rather than a simple consequence of nonuse.
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Adult-born granule cells support flexible olfactory behaviors in adulthood.
“while adult-born GCs are well-known to support flexible olfactory behaviors in adulthood [19,50–52]”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [51]
The Discussion (page unavailable) links adult-born granule cells to olfactory learning and suggests that they contribute to odor-information processing. But it also says their precise role in learning remains a matter of debate; the study shows that learning changes their survival, not that they are established supporters of flexible olfactory behavior. (LLM, conf=0.86)
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Cites
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction
Petreanu, L., & Álvarez-Buylla, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06106.2002 · Cited by 680 · see citing works
Rochefort, C., Gheusi, G., Vincent, J., & Lledo, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02679.2002 · Cited by 678 · see citing works
Self-citationExtraction of spots in biological images using multiscale products
Olivo‐Marín, J. (2002) · Pattern Recognition · doi:10.1016/s0031-3203(01)00127-3 · Cited by 540 · see citing works
Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
Lagace, D. C., Whitman, M. C., Noonan, M. A., Ables, J. L., DeCarolis, N. A., Arguello, A. A., Donovan, M. H., Fischer, S. J., Farnbauch, L. A., Beech, R. D., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3812-07.2007 · Cited by 502 · see citing works
Post-Natal Origin of Microneurones in the Rat Brain
Altman, J., & Das, G. D. (1965) · Nature · doi:10.1038/207953a0 · Cited by 481 · see citing works
Origin and function of olfactory bulb interneuron diversity
Lledo, P., Merkle, F. T., & Álvarez-Buylla, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.05.006 · Cited by 422 · see citing works
Self-citationLong‐term survival and cell death of newly generated neurons in the adult rat olfactory bulb
Winner, B., Cooper‐Kuhn, C. M., Aigner, R., Winkler, J., & Kuhn, H. G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02238.x · Cited by 412 · see citing works
Information Processing in the Mammalian Olfactory System
Lledo, P., Gheusi, G., & Vincent, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00008.2004 · Cited by 391 · see citing works
Self-citationSpatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons
Dupret, D., Fabre, A., Döbrössy, M. D., Panatier, A., Rodriguez, J. J., Lamarque, S., Lemaire, V., Oliet, S. H. R., Piazza, P., & Abrous, D. N. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050214 · Cited by 387 · see citing works
The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
Kempermann, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.002 · Cited by 372 · see citing works
Leuner, B., Mendolia‐Loffredo, S., Kozorovitskiy, Y., Samburg, D., Gould, E., & Shors, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0204-04.2004 · Cited by 289 · see citing works
Mori, K., Kishi, K., & Ojima, H. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902190308 · Cited by 286 · see citing works
Yamaguchi, M., & Mori, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406082102 · Cited by 270 · see citing works
Olfactory Discrimination Learning Increases the Survival of Adult-Born Neurons in the Olfactory Bulb
Alonso, M., Viollet, C., Gabellec, M., Meas‐Yedid, V., Olivo‐Marín, J., & Lledo, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2633-06.2006 · Cited by 263 · see citing works
Self-citationDöbrössy, M. D., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001419 · Cited by 252 · see citing works
Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis
Ninkovic, J., Mori, T., & Götz, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2572-07.2007 · Cited by 235 · see citing works
Performance of Mice in an Automated Olfactometer: Odor Detection, Discrimination and Odor Memory
Bodyak, N. D. (1999) · Chemical Senses · doi:10.1093/chemse/24.6.637 · Cited by 221 · see citing works
Lemasson, M., Saghatelyan, A., Olivo-Marin, J.-C., & Lledo, P.-M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1114-05.2005 · Cited by 218 · see citing works
Self-citationShepherd, G. M., Chen, W. R., & Greer, C. A. (2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195159561.003.0005 · Cited by 216 · see citing works
Magavi, S. S. P., Mitchell, B. D., Szentirmai, O., Carter, B. S., & Macklis, J. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2250-05.2005 · Cited by 215 · see citing works
Mitral and Tufted Cells Differ in the Decoding Manner of Odor Maps in the Rat Olfactory Bulb
Nagayama, S., Takahashi, Y. K., Yoshihara, Y., & Mori, K. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01266.2003 · Cited by 204 · see citing works
Martin, C., Gervais, R., Hugues, E., Messaoudi, B., & Ravel, N. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3433-03.2004 · Cited by 199 · see citing works
Neurogenic correlates of an olfactory discrimination task in the adult olfactory bulb
Mandairon, N., Sacquet, J., Garcia, S., Ravel, N., Jourdan, F., & Didier, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05235.x · Cited by 113 · see citing works
Fletcher, M. L., & Wilson, D. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06946.2003 · Cited by 110 · see citing works
Quantification of Chemical Vapors in Chemosensory Research
Cometto‐Muñiz, J. E. (2003) · Chemical Senses · doi:10.1093/chemse/28.6.467 · Cited by 100 · see citing works
Olariu, A., Cleaver, K. M., Shore, L. E., Brewer, M., & Cameron, H. A. (2005) · Hippocampus · doi:10.1002/hipo.20097 · Cited by 86 · see citing works
Rochefort, C., & Lledo, P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04486.x · Cited by 76 · see citing works
Self-citationAdjusting neurophysiological computations in the adult olfactory bulb
Lledo, P., & Lagier, S. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.04.011 · Cited by 52 · see citing works
Self-citationMiwa, N., & Storm, D. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1039-05.2005 · Cited by 39 · see citing works
Bisulco, S. (2003) · Chemical Senses · doi:10.1093/chemse/28.5.361 · Cited by 35 · see citing works
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Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
Tepe, B., Hill, M. C., Pekarek, B. T., Hunt, P. J., Martin, T. J., Martin, J. F., & Arenkiel, B. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.034 · Cited by 183 · see citing works
Development of the mammalian main olfactory bulb
Tufo, C., Poopalasundaram, S., Dorrego-Rivas, A., Ford, M. C., Graham, A., & Grubb, M. S. (2022) · Development · doi:10.1242/dev.200210 · Cited by 75 · see citing works
Sultan, S., Rey, N., Sacquet, J., Mandairon, N., & Didier, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3677-11.2011 · Cited by 39 · see citing works
Schellino, R., Trova, S., Cimino, I., Farinetti, A., Jongbloets, B. C., Pasterkamp, R. J., Panzica, G., Giacobini, P., De Marchis, S., & Peretto, P. (2016) · Scientific Reports · doi:10.1038/srep36063 · Cited by 28 · see citing works
Short-term availability of adult-born neurons for memory encoding
Forest, J., Moreno, M., Cavelius, M., Chalençon, L., Ziessel, A., Sacquet, J., Richard, M., Didier, A., & Mandairon, N. (2019) · Nature Communications · doi:10.1038/s41467-019-13521-7 · Cited by 24 · see citing works
Dejou, J., Athanassi, A., Brunel, T., Thevenet, M., Didier, A., & Mandairon, N. (2026) · PLOS Biology · doi:10.1371/journal.pbio.3003845 · Cited by 1 · see citing works
- Authors
- Mouret, A., Gheusi, G., Gabellec, M.-M., de Chaumont, F., Olivo-Marin, J.-C., & Lledo, P.-M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lledo, Pierre-Marie
- ORCID
- Lledo, Pierre-Marie
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-05
- Volume
- 28
- Issue
- 45
- Pages
- 11511-11516
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671302
- OpenAlex
- W2083947354
- Cited by
- 180
- References
- 31
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 18 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, olfactory bulb, interneurons, olfactory training, neuronal survival, neuronal elimination, granular layer, discrimination learning, critical period, olfactory learning
- MeSH terms
- Doublecortin Domain Proteins, Animals, Behavior, Animal, Bromodeoxyuridine, Cell Survival, Discrimination Learning, Interneurons, Male, Mice, Inbred C57BL, Microtubule-Associated Proteins, Neuropeptides, Neuropsychological Tests, Odorants, Olfactory Bulb, Time Factors, Cell Proliferation, Mice
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