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Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor
Open accessAbstract
Ciliary neurotrophic factor (CNTF) and basic fibroblast growth factor (bFGF) were tested for effects on sprouting by motor neurons innervating the adult mouse gluteus muscle. Factors were delivered by subcutaneous injection directly over the surface of the superior gluteus muscle once daily for 7 d and then end plates and axons were visualized by combined silver and cholinesterase staining. CNTF (500 ng daily) induced sprouting both from end plates and from the subset of nodes of Ranvier that are closest to the end plate. The effect of CNTF was potentiated twofold by coadministration of bFGF at doses of 2-20 ng daily, whereas treatment with bFGF alone failed to induce sprouting from either end plates or nodes of Ranvier. The sprouting stimulus delivered by the factors showed limited penetrance into the muscle and restricted lateral spread from the injection site.
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Citations
Cited by
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Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Self-citationDEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Synaptic structure and development: The neuromuscular junction
Hall, Z. W., & Sanes, J. R. (1993) · Cell · doi:10.1016/s0092-8674(05)80031-5 · Cited by 834
de Paiva, A., Meunier, F. A., Molgó, J., Aoki, K. R., & Dolly, J. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3200 · Cited by 673
Metadata
- Authors
- Gurney, M., Yamamoto, H., & Kwon, Y.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1992-08-01
- Volume
- 12
- Issue
- 8
- Pages
- 3241-3247
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1865290313
- Cited by
- 164
- References
- 0
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gurney, M., Yamamoto, H., & Kwon, Y. (1992). Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.12-08-03241.1992
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.