The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor
Open accessAbstract
The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents ( n = 408, 204 males), we used magnetic resonance imaging and acquired T1-weighted and magnetization transfer ratio (MTR) images. We also measured plasma levels of testosterone and genotyped a functional polymorphism in the AR gene, namely the number of CAG repeats in exon 1 believed to be inversely proportional to the AR transcriptional activity. We found that the testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume. The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath.
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Metadata
- Authors
- Perrin, J. S., Hervé, P.-Y., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., & Paus, T.
- Affiliations
- University of Nottingham (GB)
- Montreal Neurological Institute and Hospital (CA)
- Cégep de Jonquière (CA)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-09-17
- Volume
- 28
- Issue
- 38
- Pages
- 9519-9524
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671132
- OpenAlex
- W2026062838
- Cited by
- 331
- References
- 31
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 21 · 2019: 18 · 2018: 19 · 2017: 15 · 2016: 23 · 2015: 17 · 2014: 24 · 2013: 35 · 2012: 22
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Constellation (Université du Québec à Chicoutimi) (submittedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Heart And Stroke Foundation Of Quebec
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- adolescence, testosterone, androgen receptor, sexual dimorphism, CAG repeat polymorphism, magnetization transfer ratio, myelination, axonal caliber, brain development, sex differences
- MeSH terms
- Adolescent, Aging, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Myelin Sheath, Nerve Fibers, Myelinated, Neural Pathways, Polymorphism, Genetic, Receptors, Androgen, Sex Characteristics, Testosterone, Trinucleotide Repeats, Cell Size
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