Cited by 331Sexual Differentiation and DisordersHormonal and reproductive studiesAdvanced Neuroimaging Techniques and Applications

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Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

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Perrin, Jennifer S., Hervé, Pierre-Yves, Leonard, Gabriel, Perron, Michel, Pike, G. Bruce, Pitiot, Alain, Richer, Louis, Veillette, Suzanne, Pausova, Zdenka, Paus, Tomáš·2008·The Journal of Neuroscience

DOI 10.1523/jneurosci.1212-08.2008PMC PMC6671132

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Abstract

The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents ( n = 408, 204 males), we used magnetic resonance imaging and acquired T1-weighted and magnetization transfer ratio (MTR) images. We also measured plasma levels of testosterone and genotyped a functional polymorphism in the AR gene, namely the number of CAG repeats in exon 1 believed to be inversely proportional to the AR transcriptional activity. We found that the testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume. The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath.

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Authors: Perrin, J. S., Hervé, P.-Y., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., & Paus, T.
Affiliations: University of Nottingham (GB)
Montreal Neurological Institute and Hospital (CA)
Cégep de Jonquière (CA)
ORCID: Hervé, Pierre-Yves
Leonard, Gabriel
Pike, G. Bruce
Pitiot, Alain
Richer, Louis
Veillette, Suzanne
Paus, Tomáš
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2008-09-17
Volume: 28
Issue: 38
Pages: 9519-9524
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1212-08.2008
PMC: PMC6671132
OpenAlex: W2026062838
Cited by: 331
References: 31
Citations by year: 2026: 6 · 2025: 9 · 2024: 9 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 21 · 2019: 18 · 2018: 19 · 2017: 15 · 2016: 23 · 2015: 17 · 2014: 24 · 2013: 35 · 2012: 22
FWCI: 8.49
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Constellation (Université du Québec à Chicoutimi) (submittedVersion)
Funders: Heart and Stroke Foundation of Canada
Heart And Stroke Foundation Of Quebec
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: adolescence, testosterone, androgen receptor, sexual dimorphism, CAG repeat polymorphism, magnetization transfer ratio, myelination, axonal caliber, brain development, sex differences
MeSH terms: Adolescent, Aging, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Myelin Sheath, Nerve Fibers, Myelinated, Neural Pathways, Polymorphism, Genetic, Receptors, Androgen, Sex Characteristics, Testosterone, Trinucleotide Repeats, Cell Size

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Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

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