Sequence Reactivation in the Hippocampus Is Impaired in Aged Rats
Open accessAbstract
The hippocampus is thought to coordinate memory consolidation by reactivating traces from behavioral experience when the brain is not actively processing new input. In fact, during slow-wave sleep, the patterns of CA1 pyramidal cell ensemble activity correlations are reactivated in both young and aged rats. In addition to correlated activity patterns, repetitive track running also creates a recurring sequence of pyramidal cell activity. The present study compared CA1 sequence activity pattern replay in young and old animals during rest periods after behavior. Whereas the young rats exhibited significant sequence reactivation, it was markedly impaired in the aged animals. When the spatial memory scores of all animals were compared with the degree of sequence reactivation, there was a significant correlation. The novel finding that weak replay of temporal patterns has behavioral consequences, strengthens the idea that reactivation processes are integral to memory consolidation.
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Spontaneous memory reactivations during sleep correlate with later memory performance.
“and that spontaneous memory reactivations during sleep correlate with later memory performance (335, 448, 449).”
From About Sleep's Role in Memory (2013) · cites this paper as [448]
The Results (‘Sequence Reactivation versus Morris Swim Task Performance’; page unavailable) report a significant correlation between sequence reactivation during post-running rest and spatial memory performance in the combined young-and-aged rat data. But the Methods (‘Subjects and behavioral training’; page unavailable) state that the memory test occurred before electrophysiological recording, not later. The recording period also included sleep or quiet rest, rather than sleep alone. (LLM, conf=0.92)
Experimental — accuracy not yet measuredThe weakening of temporally sequenced reactivation patterns in aged rats did not appear to be a consequence of age-related decreases in SWS.
“The weakening of temporally sequenced reactivation patterns in aged rates did not appear to be a consequence of age-related decreases in SWS.”
From About Sleep's Role in Memory (2013) · cites this paper as [448]
Aging rats at rest after spatial memory encoding showed weaker reactivations of temporal firing patterns in hippocampal neuron ensembles, and this was associated with diminished spatial memory performance in the Morris Water maze at the final testing day.
“Consistent with this notion, aging rats at rest after spatial memory encoding showed weaker reactivations of temporal firing patterns in hippocampal neuron ensembles, and this was associated with diminished spatial memory performance in the Morris Water maze at the final testing day (e.g., Ref. 448, see sect.IIIA4).”
From About Sleep's Role in Memory (2013) · cites this paper as [448]
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- Authors
- Gerrard, J. L., Burke, S. N., McNaughton, B. L., & Barnes, C. A.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Barnes, Carol A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-07-30
- Volume
- 28
- Issue
- 31
- Pages
- 7883-7890
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2703197
- OpenAlex
- W2007917431
- Cited by
- 97
- References
- 82
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 10 · 2012: 6
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG012609, R37AG012609, R01AG012609)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- aging, CA1 pyramidal neurons, memory consolidation, slow-wave sleep, spatial memory, track running, aged rats
- MeSH terms
- Aging, Animals, Hippocampus, Male, Memory, Memory Disorders, Psychomotor Performance, Rats, Inbred F344, Time Factors, Maze Learning, Rats
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