The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism
Open accessAbstract
In the adult female rat, the densities of dendritic spines and synapses on hippocampal CA1 pyramidal cells are dependent upon the ovarian steroid estradiol; moreover, spine and synapse density fluctuate naturally as ovarian steroid levels vary across the estrous cycle. To determine whether the effects of estradiol on dendritic spine density require activation of specific neurotransmitter systems, we have treated animals concurrently with estradiol and one of four selective neurotransmitter receptor antagonists: MK 801, a noncompetitive NMDA receptor antagonist; CGP 43487, a competitive NMDA receptor antagonist; NBQX, an AMPA receptor antagonist; or scopolamine, a muscarinic receptor antagonist. Our results indicate that the effects of estradiol can be blocked by treatment with either of the NMDA receptor antagonists, but treatment with an AMPA or muscarinic receptor antagonist has no effect on spine density. Thus, we have concluded that estradiol exerts its effect on hippocampal dendritic spine density via a mechanism requiring activation specifically of NMDA receptors.
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Cites
Simerly, R. B., Swanson, L. W., Chang, C., & Muramatsu, M. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902940107 · Cited by 2,118
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D., & Keiner, M. (1973) · Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
Gould, E., Woolley, C., Frankfurt, M., & McEwen, B. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01286.1990 · Cited by 1,368
Self-citationNaturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
Woolley, C., Gould, E., Frankfurt, M., & McEwen, B. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-12-04035.1990 · Cited by 1,097
Self-citationWoolley, C. S., & McEwen, B. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903360210 · Cited by 1,071
Self-citationWoolley, C., & McEwen, B. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02549.1992 · Cited by 990
Self-citationBlockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex
Kleinschmidt, A., Bear, M. F., & Singer, W. (1987) · Science · doi:10.1126/science.2443978 · Cited by 909
Excitatory amino acid receptors and synaptic plasticity
Collingridge, G. L., & Singer, W. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90011-v · Cited by 865
Organizational and activational effects of sex steroids on brain and behavior: A reanalysis
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Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
Self-citationLife and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Estrogen Actions Throughout the Brain
McEwen, B. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.357 · Cited by 915
Self-citationMagarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863
Self-citation
Metadata
- Authors
- Woolley, C., & McEwen, B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-12-01
- Volume
- 14
- Issue
- 12
- Pages
- 7680-7687
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2121403142
- Cited by
- 688
- References
- 36
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Woolley, C., & McEwen, B. (1994). Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.14-12-07680.1994
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
