Life and Death of Neurons in the Aging Brain
Abstract
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aging is accompanied by marked declines in cognitive function associated with the entorhinal cortex.
“Aging is accompanied by marked declines in cognitive function associated with the entorhinal cortex15”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [15]
The aged primate is the best available model of age-related neurodegeneration in humans, showing cognitive decline with aging and reductions in neuronal function.
“The aged primate is the best available model of age-related neurodegeneration in humans, showing cognitive decline with aging and reductions in neuronal function15.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [15]
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Human Aging: Usual and Successful
Rowe, J. W., & Kahn, R. L. (1987) · Science · doi:10.1126/science.3299702 · Cited by 3,384 · see citing works
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282 · see citing works
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,050 · see citing works
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
The unbiased estimation of number and sizes of arbitrary particles using the disector
Sterio, D. C. (1984) · Journal of Microscopy · doi:10.1111/j.1365-2818.1984.tb02501.x · Cited by 2,533 · see citing works
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180 · see citing works
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · see citing works
Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
Tang, M., Jacobs, D. M., Stern, Y., Marder, K. S., Schofield, P., Gurland, B. J., Andrews, H., & Mayeux, R. P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03356-9 · Cited by 1,647 · see citing works
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,495 · see citing works
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
Gómez‐Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E., & Hyman, B. T. (1997) · Annals of Neurology · doi:10.1002/ana.410410106 · Cited by 1,489 · see citing works
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434 · see citing works
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418 · see citing works
Human Memory and the Cholinergic System
Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works
Unbiased stereological estimation of the number of neurons in the human hippocampus
West, M. J., & Gundersen, H. J. G. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960102 · Cited by 1,153 · see citing works
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128 · see citing works
Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90117-v · Cited by 1,114 · see citing works
Woolley, C. S., & McEwen, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02549.1992 · Cited by 987 · see citing works
Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987 · see citing works
New stereological methods for counting neurons
West, M. J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90112-o · Cited by 940 · see citing works
Wischik, C. M., Novak, M., Thøgersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4506 · Cited by 939 · see citing works
Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region
Witter, M. P., Groenewegen, H. J., Lopes, F. H. D. S., & Lohman, A. H. M. (1989) · Progress in Neurobiology · doi:10.1016/0301-0082(89)90009-9 · Cited by 918 · see citing works
Meunier, M., Bachevalier, J., Mishkin, M., & Murray, E. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05418.1993 · Cited by 900 · see citing works
Beckman, J. S., Carson, M. A., Smith, C. D. L., & Koppenol, W. H. (1993) · Nature · doi:10.1038/364584a0 · Cited by 876 · see citing works
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., Yagi, T., Aizawa, S., Inoue, Y., Sugiyama, H., et al. (1995) · Nature · doi:10.1038/373151a0 · Cited by 859 · see citing works
Goodman, Y., Bruce‐Keller, A. J., Cheng, B., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66051836.x · Cited by 830 · see citing works
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works
Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., & Wisniewski, H. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91396-6 · Cited by 818 · see citing works
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772 · see citing works
Greenberg, S. G., & Davies, P. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.5827 · Cited by 732 · see citing works
Ripps, M. E., Huntley, G. W., Hof, P. R., Morrison, J., & Gordon, J. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.689 · Cited by 725 · see citing works
Self-citationPreserved neuron number in the hippocampus of aged rats with spatial learning deficits.
Rapp, P., & Gallagher, M. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.18.9926 · Cited by 687 · see citing works
Woolley, C. S., & McEwen, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07680.1994 · Cited by 679 · see citing works
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
Beckman, J. S., & Crow, J. P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210330 · Cited by 676 · see citing works
Perforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672 · see citing works
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works
Regionally specific loss of neurons in the aging human hippocampus.
West, M. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90113-p · Cited by 638 · see citing works
Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex
Brody, H. (1955) · The Journal of Comparative Neurology · doi:10.1002/cne.901020206 · Cited by 624 · see citing works
Evidence of neuronal oxidative damage in Alzheimer's disease.
Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works
Lewis, D., Campbell, M., Terry, R., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-06-01799.1987 · Cited by 578 · see citing works
Self-citationDo defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
Beal, M. F., Hyman, B. T., & Koroshetz, W. J. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90117-5 · Cited by 574 · see citing works
Côté, F., Collard, J.-F., & Julien, J. (1993) · Cell · doi:10.1016/0092-8674(93)90158-m · Cited by 552 · see citing works
Bolaños, J. P., Almeida, Á., Stewart, V. C., Peuchen, S., Land, J. M., Clark, J. B., & Heales, S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68062227.x · Cited by 519 · see citing works
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works
Self-citationEpitopes that span the tau molecule are shared with paired helical filaments
Kosik, K. S., Orecchio, L. D., Binder, L. I., Trojanowski, J. Q., Lee, V. M.-Y., & Lee, G. S. (1988) · Neuron · doi:10.1016/0896-6273(88)90129-8 · Cited by 497 · see citing works
Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R., & Mayford, M. R. (1995) · Cell · doi:10.1016/0092-8674(95)90010-1 · Cited by 475 · see citing works
Morris, J. C., McKeel, D. W., Storandt, M., Rubin, E. H., Price, J. L., Grant, E. A., Ball, M. J., & Berg, L. (1991) · Neurology · doi:10.1212/wnl.41.4.469 · Cited by 473 · see citing works
Memory‐related neural systems in Alzheimer's disease: An anatomic study
Hyman, B. T., Hoesen, G. W. V., & Damasio, A. R. (1990) · Neurology · doi:10.1212/wnl.40.11.1721 · Cited by 449 · see citing works
THE USE OF ANIMAL MODELS TO STUDY THE EFFECTS OF AGING ON COGNITION
Gallagher, M., & Rapp, P. R. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.339 · Cited by 430 · see citing works
Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease
Convit, A., De Leon, M. J., Tarshish, C., De Santi, S., Tsui, W., Rusinek, H., & George, A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00001-8 · Cited by 427 · see citing works
Williams, R. W., & RAKIC, P. T. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902780305 · Cited by 426 · see citing works
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.
Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed Central · Cited by 425 · see citing works
Rosene, D. L., & Van Hoesen, G. W. (1987) · Cerebral Cortex · doi:10.1007/978-1-4615-6616-8_9 · Cited by 422 · see citing works
Memory: brain systems and behavior
Squire, L. R., & Zola-Morgan, S. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90144-0 · Cited by 416 · see citing works
Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.
Mirra, S. S., Hart, M. N., & Terry, R. D. (1993) · PubMed · Cited by 412 · see citing works
Rogers, J., & Morrison, J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-10-02801.1985 · Cited by 410 · see citing works
Self-citationQuantitative synaptic alterations in the human neocortex during normal aging
Masliah, E., Mallory, M. E., Hansen, L. A., DeTeresa, R. M., & Terry, R. D. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.192 · Cited by 408 · see citing works
Masliah, E., Sisk, A., Mallory, M. E., Mucke, L., Schenk, D., & Games, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05795.1996 · Cited by 387 · see citing works
Topographical organization of the entorhinal projection to the dentate gyrus of the monkey
Witter, M., Hoesen, G. W. V., & Amaral, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-01-00216.1989 · Cited by 380 · see citing works
Observations in a preliminary open trial of estradiol therapy for senile dementia-alzheimer's type
Fillit, H. M., Weinreb, H. J., Cholst, I. N., Luine, V. N., McEwen, B. S., Amador, R., & Zabriskie, J. B. (1986) · Psychoneuroendocrinology · doi:10.1016/0306-4530(86)90019-3 · Cited by 376 · see citing works
Differential Regulation of NMDAR1 mRNA and Protein by Estradiol in the Rat Hippocampus
Gazzaley, A. H., Weiland, N. G., McEwen, B. S., & Morrison, J. H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06830.1996 · Cited by 375 · see citing works
Self-citationHof, P. R., Morrison, J. H., & Cox, K. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903010105 · Cited by 365 · see citing works
Self-citationLee, M. K., Marszalek, J. R., & Cleveland, D. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90263-1 · Cited by 365 · see citing works
Are reactive oxygen species involved in Alzheimer's disease?
Benzi, G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00066-n · Cited by 365 · see citing works
Multistability of cognitive maps in the hippocampus of old rats
Barnes, C. A., Suster, M. S., Shen, J., & McNaughton, B. L. (1997) · Nature · doi:10.1038/40859 · Cited by 360 · see citing works
Neurobiological Bases of Age-Related Cognitive Decline in the Rhesus Monkey
Peters, A., Rosene, D. L., Moss, M. B., Kemper, T. L., Abraham, C. R., Tigges, J., & Albert, M. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199608000-00001 · Cited by 344 · see citing works
Ritchie, K. A., & Kildea, D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91556-7 · Cited by 340 · see citing works
Elmquist, J. K., Scammell, T. E., Jacobson, C. D., & Saper, C. B. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960715)371:1 · Cited by 335 · see citing works
Normal aging: regionally specific changes in hippocampal synaptic transmission
Barnes, C. A. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90029-9 · Cited by 334 · see citing works
Nalbantoglu, J. N., Santiago, G. T., Lahsaïni, A., Poirier, J., Goncalves, O., Verge, G. M., Momoli, F., Welner, S. A., Massicotte, G., Julien, J., et al. (1997) · Nature · doi:10.1038/387500a0 · Cited by 334 · see citing works
Subsynaptic Plate Perforations: Changes with Age and Experience in the Rat
Greenough, W. T., West, R. W., & DeVoogd, T. J. (1978) · Science · doi:10.1126/science.715459 · Cited by 330 · see citing works
Geinisman, Y., deToledo‐Morrell, L., Morrell, F., & Heller, R. E. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00047-l · Cited by 318 · see citing works
Lautenschlager, N. T., Cupples, L. A., Rao, V. S., Auerbach, S. A., Becker, R., Burke, J., Chui, H., Duara, R., Foley, E. J., Glatt, S. L., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.641 · Cited by 298 · see citing works
Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.
Masliah, E., Terry, R. D., Alford, M. F., DeTeresa, R. M., & Hansen, L. A. (1991) · PubMed Central · Cited by 296 · see citing works
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13410 · Cited by 292 · see citing works
Braak, H., & Braak, E. (1985) · Acta Neuropathologica · doi:10.1007/bf00690836 · Cited by 287 · see citing works
Bouras, C., Hof, P. R., Giannakopoulos, P., Michel, J.-P., & Morrison, J. H. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.2.138 · Cited by 280 · see citing works
Self-citationBerg, L., McKeel, D. W., Miller, J. P., Baty, J., & Morris, J. C. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540040011008 · Cited by 257 · see citing works
Cognitive and neurobiologic markers of early Alzheimer disease
Albert, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13547 · Cited by 246 · see citing works
Neuron numbers and sizes in aging brain: Comparisons of human, monkey, and rodent data
Flood, D. G., & Coleman, P. D. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80098-8 · Cited by 242 · see citing works
Trojanowski, J., Schmidt, M. L., Shin, R., Bramblett, G., Rao, D., & Lee, V. (1993) · Brain Pathology · doi:10.1111/j.1750-3639.1993.tb00725.x · Cited by 231 · see citing works
The effects of aging on area 46 of the frontal cortex of the rhesus monkey.
Peters, A., Leahu, D., Moss, M. B., & McNally, K. J. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.6.621 · Cited by 214 · see citing works
Hof, P. R., & Morrison, J. H. (1991) · Experimental Neurology · doi:10.1016/0014-4886(91)90096-u · Cited by 196 · see citing works
Self-citationRebeck, G. W., Perls, T. T., West, H. L., Sodhi, P., Lipsitz, L. A., & Hyman, B. T. (1994) · Neurology · doi:10.1212/wnl.44.8.1513 · Cited by 189 · see citing works
HOF, P. R., COX, K., Young, W. G., Celio, M. R., Rogers, J., & Morrison, J. H. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199107000-00006 · Cited by 188 · see citing works
Self-citationCanto, M. C. D., & Gurney, M. E. (1997) · Acta Neuropathologica · doi:10.1007/s004010050650 · Cited by 188 · see citing works
Ksiȩżak-Reding, H., Dickson, D. W., Davies, P., & Yen, S. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3410 · Cited by 181 · see citing works
Moore, C. I., Browning, M. D., & Rose, G. M. (1993) · Hippocampus · doi:10.1002/hipo.450030106 · Cited by 177 · see citing works
Gazzaley, A. H., Siegel, S. J., Kordower, J. H., Mufson, E. J., & Morrison, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3121 · Cited by 177 · see citing works
Self-citationDayan, A. D. (1970) · Acta Neuropathologica · doi:10.1007/bf00687663 · Cited by 176 · see citing works
Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease
Hof, P. R., Nimchinsky, E. A., Celio, M. R., Bouras, C., & Morrison, J. H. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90504-e · Cited by 172 · see citing works
Self-citationDendritic extent in human dentate gyrus granule cells in normal aging and senile dementia
Flood, D. G., Buell, S. J., Horwitz, G. J., & Coleman, P. D. (1987) · Brain Research · doi:10.1016/0006-8993(87)90027-8 · Cited by 164 · see citing works
Morrison, J. H., Lewis, D. A., Campbell, M. J., Huntley, G. W., Benson, D. L., & Bouras, C. (1987) · Brain Research · doi:10.1016/0006-8993(87)90914-0 · Cited by 164 · see citing works
Self-citationHaug, H., Kühl, S., Mecke, E., Nl, S., & Wasner, K. (1984) · PubMed · Cited by 157 · see citing works
Laminar distribution of neocortical senile plaques in senile dementia of the alzheimer type
Duyckaerts, C. J., Hauw, J., Bastenaire, F., Piette, F., Poulain, C., Rainsard, V., Javoy-Agid, F., & Berthaux, P. (1986) · Acta Neuropathologica · doi:10.1007/bf00686079 · Cited by 151 · see citing works
Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90096-t · Cited by 149 · see citing works
Bouras, C., Hof, P. R., & Morrison, J. H. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90305-5 · Cited by 142 · see citing works
Self-citationVickers, J., Riederer, B. M., Marugg, R., Buée-Scherrer, V., Buée, L., Delacourte, A., & Morrison, J. H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90310-7 · Cited by 135 · see citing works
Self-citationAlzheimer's paired helical filaments share epitopes with neurofilament side arms.
Miller, C. C. J., Brion, J., Calvert, R. A., Chin, T., Eagles, P. A. M., Downes, M. J., Flament-Durand, J., Haugh, M., Kahn, J., & Probst, A. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04209.x · Cited by 130 · see citing works
Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats
Deupree, D. L., Turner, D. A., & Watters, C. L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90164-q · Cited by 128 · see citing works
Delacourte, A., Flament, S., Dibe, E. M., Hublau, P., Sablnni�re, P., H�mon, B., Sh�rrer, V., & D�fossez, A. (1990) · Acta Neuropathologica · doi:10.1007/bf00308912 · Cited by 127 · see citing works
Impaired spatial information processing in aged monkeys with preserved recognition memory
Rapp, P. R., Kansky, M. T., & Roberts, J. A. (1997) · Neuroreport · doi:10.1097/00001756-199705260-00026 · Cited by 118 · see citing works
Hof, P. R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530330070019 · Cited by 118 · see citing works
Self-citationReproductive senescence predicts cognitive decline in aged female monkeys
Roberts, J. A., Gilardi, K. V. K., Lasley, B. L., et al. (1997) · Neuroreport · doi:10.1097/00001756-199705260-00048 · Cited by 113 · see citing works
Li, Y., Takada, M., Kaneko, T., & Mizuno, N. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960930)373:4 · Cited by 112 · see citing works
Transgenic mouse brain histopathology resembles early Alzheimer's disease
Higgins, L. S., Holtzman, D. M., Rabin, J., Mobley, W. C., & Cordell, B. (1994) · Annals of Neurology · doi:10.1002/ana.410350514 · Cited by 112 · see citing works
Brion, J., Hanger, D. P., Couck, A. M., & Anderton, B. H. (1991) · Biochemical Journal · doi:10.1042/bj2790831 · Cited by 109 · see citing works
Protein kinases and phosphorylation in neurologic disorders and cell death.
Saitoh, T., Masliah, E., Jin, L., Cole, G. M., Wieloch, T. W., & Shapiro, I. P. (1991) · PubMed · Cited by 108 · see citing works
Neuropathological background of twenty-seven centenarian brains
Mizutani, T., & Shimada, H. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90047-o · Cited by 106 · see citing works
Giannakopoulos, P., Hof, P. R., Mottier, S., Michel, J., & Bouras, C. (1994) · Acta Neuropathologica · doi:10.1007/bf00294172 · Cited by 104 · see citing works
Self-citationEffects of aging on the neurons within area 17 of rhesus monkey cerebral cortex
Vincent, S. L., Peters, A., & Tigges, J. (1989) · The Anatomical Record · doi:10.1002/ar.1092230312 · Cited by 100 · see citing works
Giannakopoulos, P., Hop, P. R., Kövari, E., Vallet, P. G., Herrmann, F. R., & Bouras, C. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199612000-00004 · Cited by 98 · see citing works
Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease
Vickers, J. C., Delacourte, A., & Morrison, J. H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91134-z · Cited by 97 · see citing works
Self-citationMurine models of brain aging and age-related neurodegenerative diseases
Jucker, M., & Ingram, D. K. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02243-7 · Cited by 94 · see citing works
McIntosh, L. J., Trush, M. A., & Troncoso, J. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00573-4 · Cited by 91 · see citing works
Vickers, J. C., Chin, D., Edwards, A.-M., Sampson, V., Harper, C. G., & Morrison, J. H. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0133 · Cited by 86 · see citing works
Self-citationFama, R., Sullivan, E., Shear, P., Marsh, L., Yesavage, J., Tinklenberg, J., Lim, K. O., & Pfefferbaum, A. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550180039010 · Cited by 85 · see citing works
Higgins, L. S., Rodems, J. M., Catalano, R., Quon, D. H., & Cordell, B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4402 · Cited by 80 · see citing works
Giannakopoulos, P., Hof, P. R., Giannakopoulos, A.-S., Herrmann, F. R., Michel, J.-P., & Bouras, C. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540360028012 · Cited by 78 · see citing works
Self-citationSampson, V., Morrison, J. H., & Vickers, J. C. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6433 · Cited by 75 · see citing works
Self-citationAsada, T., Yamagata, Z., Kinoshita, T., Kinoshita, A., Kariya, T., Asaka, A., & Kakuma, T. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb02431.x · Cited by 75 · see citing works
A quantitative histological study of early clinical and preclinical Alzheimer's disease
Hubbard, B. M., FENTONM, G. W., & Anderson, J. M. (1990) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1990.tb00940.x · Cited by 75 · see citing works
Vickers, J. C., Morrison, J., Friedrich, V., Elder, G., Perl, D., Katz, R., & Lazzarini, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05603.1994 · Cited by 68 · see citing works
Self-citationNeuronal population of area 4 during the life span of the rhesus monkey
Tigges, J., Herndon, J. G., & Peters, A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90546-c · Cited by 64 · see citing works
Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles.
Schmidt, M. L., Lee, V. M. ‐., & Trojanowski, J. Q. (1990) · PubMed Central · Cited by 63 · see citing works
Giannakopoulos, P., Hof, P. R., Surini, M., Michel, J., & Bouras, C. (1993) · Acta Neuropathologica · doi:10.1007/bf00334669 · Cited by 61 · see citing works
Self-citationChang, F.-L. F., Isaacs, K. R., & Greenough, W. T. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90082-u · Cited by 59 · see citing works
The elderly brain. A quantitative analysis in the cerebral cortex of two cases.
Ej, C. (1972) · PubMed · Cited by 56 · see citing works
Aging and the Meynert cells in rhesus monkey primary visual cortex
Peters, A., & Sethares, C. (1993) · The Anatomical Record · doi:10.1002/ar.1092360416 · Cited by 52 · see citing works
Mild Age-Related Changes in the Dentate Gyrus of Adult Rhesus Monkeys
Tigges, J., Herndon, J. G., & Rosene, D. L. (1995) · Cells Tissues Organs · doi:10.1159/000147713 · Cited by 48 · see citing works
Hauw, J., Vignolo, P., Duyckaerts, C. J., Beck, H., Forette, F., Henry, J. F., Laurent, M., Piette, F., Sachet, A., & Berthaux, P. (1986) · PubMed · Cited by 48 · see citing works
Tigges, J., Herndon, J. G., & Rosene, D. L. (1996) · Cells Tissues Organs · doi:10.1159/000147867 · Cited by 46 · see citing works
Hof, P. R. (2008) · European Neurology · doi:10.1159/000117414 · Cited by 43 · see citing works
Self-citationKim, C. B. Y., Pier, L. P., & Spear, P. D. (1997) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199701)247:1 · Cited by 42 · see citing works
A Cellular Mechanism for the Neuronal Changes Underlying Alzheimer‘s Disease
Vickers, J. C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00662-8 · Cited by 32 · see citing works
Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital
Giannakopoulos, P., Hof, P. R., Giannakopoulos, A.-S., Buée‐Scherrer, V., Surini, M., Delacourte, A., & Bouras, C. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106745 · Cited by 24 · see citing works
Self-citationDiagnostic différentiel histologique de la maladie d'Alzheimer et de la démence sénile
Mutrux, S. (2008) · Monatsschrift für Psychiatrie und Neurologie · doi:10.1159/000148270 · Cited by 23 · see citing works
(1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902810213 · Cited by 15 · see citing works
Age versus ageing as a cause of dementia
Winker, M. A., Ritchie, K. A., Kildea, D., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92500-7 · Cited by 8 · see citing works
The role of ovarian hormones in cognition and dementia
Birge, S. J. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_7.1s · Cited by 8 · see citing works
LACOSTE, M. C. D., & White, C. L. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90022-4 · Cited by 1 · see citing works
?imi?, G., Kostovi?, I., Winblad, B., & Bogdanovi?, N. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970324)379:4
Flagged first, then by citations
Cited by
Sorted by citations
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604 · see citing works
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · see citing works
RetractedMapping cortical change across the human life span
Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003) · Nature Neuroscience · doi:10.1038/nn1008 · Cited by 2,328 · see citing works
Thinning of the Cerebral Cortex in Aging
Salat, D. H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh032 · Cited by 1,851 · see citing works
The Impact of Age on Cognition
Murman, D. (2015) · Seminars in Hearing · doi:10.1055/s-0035-1555115 · Cited by 1,619 · see citing works
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03295.2003 · Cited by 1,425 · see citing works
LIFESPAN PSYCHOLOGY: Theory and Application to Intellectual Functioning
Baltes, P. B., Staudinger, U. M., & Lindenberger, U. (1999) · Annual Review of Psychology · doi:10.1146/annurev.psych.50.1.471 · Cited by 1,281 · see citing works
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208 · see citing works
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works
Self-citationDynamics of Gray Matter Loss in Alzheimer's Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132 · see citing works
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079 · see citing works
Self-citationGene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works
von Bartheld, C. S., Bahney, J., & Herculano‐Houzel, S. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.24040 · Cited by 1,063 · see citing works
Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works
The ageing cortical synapse: hallmarks and implications for cognitive decline
Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works
Self-citationThe biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.
Delacourte, A., David, J. P., Sergeant, N., Buée, L., Wattez, A., Vermersch, P., Ghozali, F., Fallet-Bianco, C., Pasquier, F., Lebert, F., et al. (1999) · Neurology · doi:10.1212/wnl.52.6.1158 · Cited by 828 · see citing works
Neuropathology of Alzheimer's Disease
Perl, D. P. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20157 · Cited by 825 · see citing works
Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., & Mattson, M. P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06920.2000 · Cited by 784 · see citing works
Durga, J., van Boxtel, M. P., Schouten, E. G., Kok, F. J., Jolles, J., Katan, M. B., & Verhoef, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60109-3 · Cited by 758 · see citing works
The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
Jacobsen, J. S., Wu, C.-C., Redwine, J. M., Comery, T. A., Arias, R., Bowlby, M., Martone, R., Morrison, J. H., Pangalos, M. N., Reinhart, P. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600948103 · Cited by 701 · see citing works
Self-citationPeng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03135.x · Cited by 691 · see citing works
Early-life programming of later-life brain and behavior: a critical role for the immune system
Bilbo, S. D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.014.2009 · Cited by 652 · see citing works
The effects of normal aging on myelin and nerve fibers: a review
Peters, A. (2002) · Journal of Neurocytology · doi:10.1023/a:1025731309829 · Cited by 577 · see citing works
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
D'Amelio, M., Cavallucci, V., Middei, S., Marchetti, C., Pacioni, S., Ferri, A., Diamantini, A., De Zio, D., Carrara, P., Battistini, L., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2709 · Cited by 572 · see citing works
One-year Age Changes in MRI Brain Volumes in Older Adults
Resnick, S. M. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.5.464 · Cited by 517 · see citing works
A neuronal morphologic type unique to humans and great apes
Nimchinsky, E. A., Gilissen, E., Allman, J. M., Perl, D. P., Erwin, J. M., & Hof, P. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5268 · Cited by 494 · see citing works
Self-citationEstrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470 · see citing works
Self-citationDumitriu, D., Hao, J., Hara, Y., Kaufmann, J., Janssen, W. G. M., Lou, W., Rapp, P. R., & Morrison, J. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6410-09.2010 · Cited by 439 · see citing works
Self-citationNeuroplasticity Failure in Alzheimer's Disease
Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works
Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging
Carnio, S., LoVerso, F., Baraibar, M. A., Longa, E., Khan, M. M., Maffei, M., Reischl, M., Canepari, M., Loefler, S., Kern, H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.061 · Cited by 423 · see citing works
The impact of aging and gender on brain viscoelasticity
Sack, I., Beierbach, B., Wuerfel, J., Klatt, D., Hamhaber, U., Papazoglou, S., Martus, P., & Braun, J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.040 · Cited by 423 · see citing works
The aging brain: morphomolecular senescence of cortical circuits
Hof, P. R., & Morrison, J. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.013 · Cited by 411 · see citing works
Self-citationCasas, C., Sergeant, N., Itier, J.-M., Blanchard, V., Wirths, O., van der Kolk, N., Vingtdeux, V., van de Steeg, E., Ret, G., Canton, T., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63388-3 · Cited by 400 · see citing works
Apoptosis in skeletal muscle with aging
Dirks, A., & Leeuwenburgh, C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00458.2001 · Cited by 377 · see citing works
The potential effects of meditation on age-related cognitive decline: a systematic review.
Gard, T., Hölzel, B. K., & Lazar, S. W. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12348 · Cited by 363 · see citing works
Zhao, J., Fu, Y., Yasvoina, M., Shao, P., Hitt, B., O'Connor, T., Logan, S., Maus, E., Citron, M., Berry, R., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4396-06.2007 · Cited by 365 · see citing works
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Charlton, R. A., Barrick, T. R., McIntyre, D. J., Shen, Y., O'Sullivan, M., Howe, F. A., Clark, C. A., Morris, R. G., & Markus, H. S. (2006) · Neurology · doi:10.1212/01.wnl.0000194256.15247.83 · Cited by 354 · see citing works
Hippocampal hypometabolism predicts cognitive decline from normal aging
Mosconi, L., De Santi, S., Li, J., Tsui, W. H., Li, Y., Boppana, M., Laska, E., Rusinek, H., & de Leon, M. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.008 · Cited by 360 · see citing works
Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease
Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0901-04.2004 · Cited by 345 · see citing works
Mormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Amariglio, R. E., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2031 · Cited by 328 · see citing works
The frontal aging hypothesis evaluated.
GREENWOOD, P. M. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700666092 · Cited by 311 · see citing works
Age and gender effects on microglia and astrocyte numbers in brains of mice
Mouton, P. R., Long, J. M., Lei, D.-L., Howard, V., Jucker, M., Calhoun, M. E., & Ingram, D. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03475-3 · Cited by 320 · see citing works
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
Ohno, M., Cole, S. L., Yasvoina, M., Zhao, J., Citron, M., Berry, R., Disterhoft, J. F., & Vassar, R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.008 · Cited by 290 · see citing works
Dendritic spine changes associated with normal aging
Dickstein, D. L., Weaver, C. M., Luebke, J. I., & Hof, P. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.077 · Cited by 289 · see citing works
Self-citationKochunov, P., Thompson, P. M., Lancaster, J. L., Bartzokis, G., Smith, S., Coyle, T., Royall, D. R., Laird, A., & Fox, P. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.021 · Cited by 250 · see citing works
Bayer (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00008 · Cited by 252 · see citing works
Perineuronal nets potentially protect against oxidative stress
Morawski, M., Brückner, M. K., Riederer, P., Brückner, G., & Arendt, T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.017 · Cited by 246 · see citing works
Jazvinšćak Jembrek, M., Hof, P. R., & Šimić, G. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/346783 · Cited by 244 · see citing works
Self-citationMolecular aging in human prefrontal cortex is selective and continuous throughout adult life
Erraji-Benchekroun, L., Underwood, M. D., Arango, V., Galfalvy, H., Pavlidis, P., Smyrniotopoulos, P., Mann, J. J., & Sibille, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.034 · Cited by 236 · see citing works
Uddin, M., Wildman, D. E., Liu, G., Xu, W., Johnson, R. M., Hof, P. R., Kapatos, G., Grossman, L. I., & Goodman, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308725100 · Cited by 238 · see citing works
Self-citationPetit-Taboué, M. C., Landeau, B., Desson, J. F., Desgranges, B., & Baron, J. C. (1998) · NeuroImage · doi:10.1006/nimg.1997.0318 · Cited by 221 · see citing works
The effects of normal aging on myelinated nerve fibers in monkey central nervous system
Peters, A. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.011.2009 · Cited by 211 · see citing works
Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H. G., Wiederhold, K.-H., Walker, L., Staufenbiel, M., & Jucker, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00515.2002 · Cited by 213 · see citing works
Age-dependent changes in sleep EEG topography
Landolt, H.-P., & Borbély, A. A. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00542-3 · Cited by 200 · see citing works
Morphological changes in nerve cells during normal aging
Pannese, E. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0308-y · Cited by 205 · see citing works
Does Alzheimer's disease begin in the brainstem?
Simic, G., Stanic, G., Mladinov, M., Jovanov‐Milosevic, N., Kostovic, I., & Hof, P. R. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01038.x · Cited by 204 · see citing works
Self-citationBrückner, G., Hausen, D., Härtig, W., Drlicek, M., Arendt, T., & Brauer, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00071-8 · Cited by 196 · see citing works
Bussière, T., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10760 · Cited by 185 · see citing works
Self-citationAge-related alterations in neurons of the mouse retina
Samuel, M. A., Zhang, Y., Meister, M., & Sanes, J. R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3580-11.2011 · Cited by 184 · see citing works
Faria, A. V., Zhang, J., Oishi, K., Li, X., Jiang, H., Akhter, K., Hermoye, L., Lee, S.-K., Hoon, A., & Stashinko, E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.238 · Cited by 180 · see citing works
Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis
Roussarie, J.-P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E. F., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.010 · Cited by 180 · see citing works
Self-citationInnate immune receptor expression in normal brain aging
Letiembre, M., Hao, W., Liu, Y., Walter, S., Mihaljevic, I., Rivest, S., Hartmann, T., & Fassbender, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.004 · Cited by 175 · see citing works
Ferrer, I. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.03.005 · Cited by 174 · see citing works
Bowley, M. P., Cabral, H., Rosene, D. L., & Peters, A. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22379 · Cited by 162 · see citing works
Brain cholesterol in normal and pathological aging
Martin, M., Dotti, C. G., & Ledesma, M. D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.03.011 · Cited by 162 · see citing works
Prolla, T. A., & Mattson, M. P. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01957-3 · Cited by 159 · see citing works
Differential effects and rates of normal aging in cerebellum and hippocampus
Woodruff-Pak, D. S., Foy, M. R., Akopian, G. G., Lee, K. H., Zach, J., Nguyen, K. P. T., Comalli, D. M., Kennard, J. A., Agelan, A., & Thompson, R. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914207107 · Cited by 143 · see citing works
A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey
Peters, A., & Kemper, T. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.015 · Cited by 135 · see citing works
Postnatal alterations in dopaminergic markers in the human prefrontal cortex
Weickert, C. S., Webster, M. J., Gondipalli, P., Rothmond, D., Fatula, R. J., Herman, M. M., Kleinman, J. E., & Akil, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.009 · Cited by 126 · see citing works
Clinical validity of Braak neuropathological staging in the oldest-old
Gold, G., Bouras, C., Kövari, E., Canuto, A., González Glaría, B., Malky, A., Hof, P. R., Michel, J.-P., & Giannakopoulos, P. (2000) · Acta Neuropathologica · doi:10.1007/s004010051163 · Cited by 128 · see citing works
Self-citationBussire, T., Gold, G., Kvari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00942-9 · Cited by 122 · see citing works
Self-citationMerrill, D. A., Chiba, A. A., & Tuszynski, M. H. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1327 · Cited by 118 · see citing works
Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging
Beckman, D., Ott, S., Donis-Cox, K., Janssen, W. G., Bliss-Moreau, E., Rudebeck, P. H., Baxter, M. G., & Morrison, J. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902301116 · Cited by 111 · see citing works
Self-citationAge and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole
Pereira, A. C., Gray, J. D., Kogan, J. F., Davidson, R. L., Rubin, T. G., Okamoto, M., Morrison, J. H., & McEwen, B. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.33 · Cited by 116 · see citing works
Self-citationPereira, A. C., Lambert, H. K., Grossman, Y. S., Dumitriu, D., Waldman, R., Jannetty, S. K., Calakos, K., Janssen, W. G., McEwen, B. S., & Morrison, J. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421285111 · Cited by 116 · see citing works
Self-citationThe future of neuroscience: flexible and wireless implantable neural electronics
McGlynn, E., Nabaei, V., Ren, E., Galeote‐Checa, G., Das, R., Curia, G., & Heidari, H. (2021) · Advanced Science · doi:10.1002/advs.202002693 · Cited by 115 · see citing works
Schröder, N., Figueiredo, L. S., & de Lima, M. N. M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121996 · Cited by 113 · see citing works
Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?
Imhof, A., Kövari, E., von Gunten, A., Gold, G., Rivara, C.-B., Herrmann, F. R., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.025 · Cited by 106 · see citing works
Self-citationCleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment
Garg, S., Timm, T., Mandelkow, E.-M., Mandelkow, E., & Wang, Y. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.09.008 · Cited by 103 · see citing works
Carpenter, W. T., Bustillo, J. R., Thaker, G. K., van Os, J., Krueger, R. F., & Green, M. J. (2009) · Psychological Medicine · doi:10.1017/s0033291709990286 · Cited by 99 · see citing works
The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009
Payton, A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9116-z · Cited by 95 · see citing works
Naik, S., Banerjee, A., Bapi, R. S., Deco, G., & Roy, D. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.007 · Cited by 89 · see citing works
Perez, S. E., Raghanti, M. A., Hof, P. R., Kramer, L., Ikonomovic, M. D., Lacor, P. N., Erwin, J. M., Sherwood, C. C., & Mufson, E. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23428 · Cited by 95 · see citing works
Self-citationChouliaras, L., L.A. van den Hove, D., Kenis, G., Keitel, S., R. Hof, P., van Os, J., W.M. Steinbusch, H., Schmitz, C., & P.F. Rutten, B. (2012) · Current Alzheimer Research · doi:10.2174/156720512800618035 · Cited by 91 · see citing works
Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology
Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., et al. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19090934 · Cited by 87 · see citing works
Altered subcellular distribution of c-Abl in Alzheimer’s disease
Jing, Z., Caltagarone, J., & Bowser, R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1062 · Cited by 83 · see citing works
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease
Bendl, J., Hauberg, M. E., Girdhar, K., Im, E., Vicari, J. M., Rahman, S., Fernando, M. B., Townsley, K. G., Dong, P., Misir, R., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01166-7 · Cited by 65 · see citing works
Jucaite, A., Forssberg, H., Karlsson, P., Halldin, C., & Farde, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.034 · Cited by 67 · see citing works
Cognitive training can reduce the rate of cognitive aging: a neuroimaging cohort study
Li, T., Yao, Y., Cheng, Y., Xu, B., Cao, X., Waxman, D., Feng, W., Shen, Y., Li, Q., Wang, J., et al. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0194-5 · Cited by 59 · see citing works
von Gunten, A., Ebbing, K., Imhof, A., Giannakopoulos, P., & Kövari, E. (2010) · Current Gerontology and Geriatrics Research · doi:10.1155/2010/358531 · Cited by 62 · see citing works
Brickman, A. M., Yeung, L.-K., Alschuler, D. M., Ottaviani, J. I., Kuhnle, G. G. C., Sloan, R. P., Luttmann-Gibson, H., Copeland, T., Schroeter, H., Sesso, H. D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216932120 · Cited by 51 · see citing works
Vartanian, O., Wertz, C. J., Flores, R. A., Beatty, E. L., Smith, I., Blackler, K., Lam, Q., & Jung, R. E. (2018) · Human Brain Mapping · doi:10.1002/hbm.24054 · Cited by 53 · see citing works
Sachdev, P., Andrews, G., Hobbs, M. J., Sunderland, M., & Anderson, T. M. (2009) · Psychological Medicine · doi:10.1017/s0033291709990262 · Cited by 48 · see citing works
Shetty, R. A., Forster, M. J., & Sumien, N. (2013) · AGE · doi:10.1007/s11357-012-9484-9 · Cited by 47 · see citing works
Mormino, E. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9267-4 · Cited by 44 · see citing works
Hwang, I. K., Lee, C. H., Li, H., Yoo, K.-Y., Choi, J. H., Kim, D. W., Kim, D.-W., Suh, H.-W., & Won, M.-H. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9584-6 · Cited by 40 · see citing works
- Authors
- Morrison, J. H., & Hof, P. R.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Morrison, John H.
- Venue
- Science
- Published
- 1997-10-17
- Volume
- 278
- Issue
- 5337
- Pages
- 412-419
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023831571
- Semantic Scholar
- 7012cafb15a5d6e03caafc71d70d47971ded391b
- Cited by
- 1,344
- References
- 158
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 36 · 2023: 33 · 2022: 35 · 2021: 28 · 2020: 50 · 2019: 40 · 2018: 44 · 2017: 35 · 2016: 45 · 2015: 50 · 2014: 50 · 2013: 47 · 2012: 51
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 05138, P50AG005138, AG-06647)
- National Institute of Mental Health (MHDA52145)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- brain aging, neuronal cell death, neurodegeneration, Alzheimer's disease, hippocampus, neocortex, functional decline, age-related cognitive impairment, hippocampal circuitry, neuronal loss
- MeSH terms
- Aging, Alzheimer Disease, Animals, Cell Survival, Estrogens, Female, Hippocampus, Humans, Male, Memory, Nerve Degeneration, Neurons, Neurofibrillary Tangles, Neurofilament Proteins, Cell Death, Entorhinal Cortex, Neocortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review