Direct Evidence for Wake-Related Increases and Sleep-Related Decreases in Synaptic Strength in Rodent Cortex
Open accessAbstract
Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex. By recording miniature EPSCs (mEPSCs) from frontal cortex slices of mice and rats that had been awake or asleep, we found that the frequency and amplitude of mEPSCs increased after waking and decreased after sleep, independent of time of day. Recovery sleep after deprivation also decreased mEPSCs, suggesting that sleep favors synaptic homeostasis. Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep.
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Frequency and amplitude of mEPSCs were increased in frontal cortex slices of mice and rats after prolonged wakefulness compared with slices obtained after sleep.
“Frequency and amplitude of mEPSCs were increased in the frontal cortex slices of mice and rats after prolonged wakefulness compared with slices obtained after sleep (740).”
From About Sleep's Role in Memory (2013) · cites this paper as [740]
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References 40 · Cited by 248
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- Authors
- Liu, Z.-W., Faraguna, U., Cirelli, C., Tononi, G., & Gao, X.-B.
- Affiliations
- Yale University (US)
- University of Wisconsin–Madison (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-06-23
- Volume
- 30
- Issue
- 25
- Pages
- 8671-8675
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2903226
- OpenAlex
- W2075067816
- Cited by
- 248
- References
- 40
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 16 · 2023: 9 · 2022: 14 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 16 · 2017: 17 · 2016: 7 · 2015: 7 · 2014: 14 · 2013: 29 · 2012: 24
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD000579)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK070723, DK 070723)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic homeostasis, sleep, wakefulness, miniature EPSCs, synaptic potentiation, synaptic depression, frontal cortex, mice, rats
- MeSH terms
- Animals, Circadian Rhythm, Frontal Lobe, Male, Neuronal Plasticity, Neurons, Sleep, Synapses, Wakefulness, Rats, Sprague-Dawley, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Mice, Rats, Miniature Postsynaptic Potentials
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