The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina
Open accessAbstract
Focal mechanical injury to the retina has been shown to slow or prevent photoreceptor degeneration near the lesion site in two animal models of retinal degeneration, inherited retinal dystrophy in the Royal College of Surgeons (RCS) and light damage in albino rats. Thus, when injured, the rat retina activates a self-protective mechanism to minimize damage. To identify injury responsive factors and cells, we examined the mRNAs for the following factors and some of their receptors: basic and acidic fibroblast growth factors (bFGF, aFGF) and FGF receptor-1 (FGFR1); ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFR alpha); brain-derived neurotrophic factor (BDNF) and its receptor trkB; and insulin-like growth factor-1 (IGF-1) and IGFR-1 receptor (IGF-1R). After a single mechanical lesion to the subretinal space and retina, there was a substantial increase in bFGF and CNTF expression that persisted for the entire 10 d period of study. The increase in bFGF mRNA after injury was prompt and great in amplitude, while the elevation of CNTF mRNA was relatively slower. In addition, there was a transient increase in FGFR1 mRNA. In situ hybridizations showed that the elevation of bFGF and CNTF was localized to the vicinity of the lesion. The expression of GFAP (glial fibrillary acidic protein) mRNA also increased in response to injury. These findings strongly suggest that increases in endogenous bFGF and/or CNTF play key roles in injury-induced photoreceptor rescue.
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Self-citationPhotoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
Faktorovich, E. G., Steinberg, R. H., Yasumura, D., Matthes, M. T., & LaVail, M. M. (1990) · Nature · doi:10.1038/347083a0 · Cited by 710
Self-citationMolecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
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The Receptor for Ciliary Neurotrophic Factor
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Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization
Wanaka, A., Johnson, E. M., & Milbrand, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90164-b · Cited by 381
Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds
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Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat
Faktorovich, E., Steinberg, R., Yasumura, D., Matthes, M., & LaVail, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03554.1992 · Cited by 351
Self-citationInfluence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat
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Self-citation
Cited by
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Müller Glial Cells in Retinal Disease
Bringmann, A., & Wiedemann, P. (2012) · Ophthalmologica · doi:10.1159/000328979 · Cited by 436
Harada, T., Harada, C., Kohsaka, S., Wada, E., Yoshida, K., Ohno, S., Mamada, H., Tanaka, K., Parada, L. F., & Wada, K. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09228.2002 · Cited by 397
Peterson, W. M., Wang, Q., Tzekova, R., & Wiegand, S. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04081.2000 · Cited by 267
Metadata
- Authors
- Wen, R., Song, Y., Cheng, T., Matthes, M., Yasumura, D., LaVail, M., & Steinberg, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-11-01
- Volume
- 15
- Issue
- 11
- Pages
- 7377-7385
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1810883461
- Cited by
- 321
- References
- 31
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wen, R., Song, Y., Cheng, T., Matthes, M., Yasumura, D., LaVail, M., & Steinberg, R. (1995). Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.15-11-07377.1995
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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