Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia
Open accessAbstract
Ciliary neurotrophic factor (CNTF) is pleiotrophic for central, peripheral, and sensory neurons. In the mature retina, CNTF treatment enhances survival of retinal ganglion and photoreceptor cells exposed to otherwise lethal perturbation. To understand its mechanism of action in vivo,the adult rat retina was used as a model to investigate CNTF-mediated activation of Janus kinase/signal transducer and activator of transcription (Jak-STAT) and ras-mitogen activated protein kinase (ras-MAPK). Intravitreal injection of Axokine, an analog of CNTF, phosphorylates STAT3 and MAPK and produces delayed upregulation of total STAT3 and STAT1 protein in rat retina. Activated STAT3 is predominantly localized in nuclei of retinal Müller (glial) cells, ganglion cells, and astrocytes, but not in photoreceptors. Although CNTF α-receptor (CNTFRα) mRNA and protein are localized predominantly if not exclusively in retinal neurons, coincident CNTF-mediated STAT3 signaling was observed in both glia and neurons. CNTF-induced activation of Jak-STAT signaling prompted us to investigate STAT3 phosphorylation after a variety of stress-mediated, conditioning stimuli. We show that STAT3 is activated in the retina after exposure to subtoxic bright light, mechanical trauma, and systemic administration of the α 2-adrenergic agonist xylazine, all of which have been shown previously to condition photoreceptors to resist light-induced degeneration. These results demonstrate that CNTF directly stimulates Jak-STAT and ras-MAPK cascades in vivo and strongly suggest that STAT3 signaling is an underlying component of neural responsiveness to stress stimuli. The observation that CNTF activates STAT3 in ganglion cells, but not in photoreceptors, suggests that Jak-STAT signaling influences neuronal survival via both direct and indirect modes of action.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In mammals, β-catenin is associated with a very limited amount of Müller glia proliferation, while pStat3 is associated with injury-induced gliosis.
“It is interesting that in mammals, β-catenin has been associated with a very limited amount of MG proliferation while pStat3 has been associated with injury-induced gliosis (Osakada et al., 2007; Peterson et al., 2000; Rhee et al., 2013; Xue et al., 2011).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Peterson et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
Bush, T. G., Puvanachandra, N., Horner, C. H., Polito, A., Ostenfeld, T., Svendsen, C. N., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1999) · Neuron · doi:10.1016/s0896-6273(00)80781-3 · Cited by 1,116 · see citing works
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.
Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A. S., Frank, D., Rozovsky, I., Stahl, N., Yancopouloš, G., & Greenberg, M. (1997) · Science · doi:10.1126/science.278.5337.477 · Cited by 1,050 · see citing works
Specific Inhibition of Stat3 Signal Transduction by PIAS3
Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., & Shuai, K. (1997) · Science · doi:10.1126/science.278.5344.1803 · Cited by 980 · see citing works
Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., & Yancopoulos, G. D. (1995) · Science · doi:10.1126/science.7871433 · Cited by 979 · see citing works
Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components
Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., et al. (1994) · Science · doi:10.1126/science.8272873 · Cited by 979 · see citing works
Intracellular Signaling Pathways Activated by Neuropathic Factors
Segal, R. A., & Greenberg, M. E. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002335 · Cited by 955 · see citing works
LaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D., & Steinberg, R. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11249 · Cited by 718 · see citing works
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
Stöckli, K. A., Lottspeich, F., Sendtner, M., Masiakowski, P., Carroll, P., Götz, R., Lindholm, D., & Thoenen, H. (1989) · Nature · doi:10.1038/342920a0 · Cited by 617 · see citing works
Unknown (1998) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(97)00012-8 · Cited by 570 · see citing works
Wegenka, U. M., Buschmann, J., Lütticken, C., Heinrich, P. C., & Horn, F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.276 · Cited by 553 · see citing works
Wegenka, U., Buschmann, J., Lütticken, C., Heinrich, P., & Horn, F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.276-288.1993 · Cited by 544 · see citing works
Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis
Chin, Y. E., Kitagawa, M., Kuida, K., Flavell, R. A., & Fu, X.-Y. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5328 · Cited by 521 · see citing works
Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)
Lin, L.-F. H., Mismer, D., Lile, J. D., Armes, L. G., Butler, E. T., Vannice, J. L., & Collins, F. (1989) · Science · doi:10.1126/science.2587985 · Cited by 417 · see citing works
Cholinergic Neuronotrophic Factors: Intraocular Distribution of Trophic Activity for Ciliary Neurons
Adler, R., Landa, K. B., Manthorpe, M., & Varon, S. S. (1979) · Science · doi:10.1126/science.451576 · Cited by 416 · see citing works
Multiple Routes to Astrocytic Differentiation in the CNS
Rajan, P., & Mckay, R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03620.1998 · Cited by 409 · see citing works
Ip, N. Y., McClain, J., Barrezueta, N. X., Aldrich, T. H., Pan, L., Li, Y., Wiegand, S. J., Friedman, B., Davis, S. H., & Yancopoulos, G. D. (1993) · Neuron · doi:10.1016/0896-6273(93)90245-m · Cited by 403 · see citing works
Self-citationSendtner, M., Stöckli, K. A., & Thoenen, H. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.1.139 · Cited by 362 · see citing works
Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses
Davis, S. H., Aldrich, T. H., Ip, N. Y., Stahl, N., Scherer, S. S., Farruggella, T. J., DiStefano, P. S., Curtis, R., Panayotatos, N., Gascan, H., et al. (1993) · Science · doi:10.1126/science.7681218 · Cited by 350 · see citing works
Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina
Wen, R., Song, Y., Cheng, T., Matthes, M. T., Yasumura, D., LaVail, M. M., & Steinberg, R. H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07377.1995 · Cited by 321 · see citing works
Mattson, M. P., & Scheff, S. W. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.3 · Cited by 308 · see citing works
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
Friedman, B., Scherer, S. S., Rudge, J. S., Helgren, M. E., Morrisey, D., McClain, J., Wang, D., Wiegand, S. J., Furth, M. E., Lindsay, R. M., et al. (1992) · Neuron · doi:10.1016/0896-6273(92)90168-d · Cited by 307 · see citing works
Self-citationEisenfeld, A. J., Bunt-Milam, A. H., & Sarthy, P. V. (1984) · PubMed · Cited by 273 · see citing works
Fukunaga, K., & Miyamoto, E. (1998) · Molecular Neurobiology · doi:10.1007/bf02740604 · Cited by 256 · see citing works
Stahl, N., & Yancopouloš, G. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251111 · Cited by 254 · see citing works
Sendtner, M., Carrol, P., Holtmann, B., Hughes, R. A., & Thoenen, H. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251110 · Cited by 253 · see citing works
Sengupta, T. K., Talbot, E. S., Scherle, P., & Ivashkiv, L. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.19.11107 · Cited by 245 · see citing works
Unoki, K., & LaVail, M. M. (1994) · PubMed · Cited by 238 · see citing works
Hagg, T., & Varon, S. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6315 · Cited by 229 · see citing works
Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)
Jain, N., Zhang, T., Fong, S., Lim, C. P., & Cao, X. (1998) · Oncogene · doi:10.1038/sj.onc.1202238 · Cited by 213 · see citing works
Boulton, T. G., Zhong, Z.-H., Wen, Z., Darnell, J. E., Jr., Stahl, N., & Yancopoulos, G. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6915 · Cited by 204 · see citing works
Cui, Q., Lü, Q., So, K., & Yip, H. K.-F. (1999) · PubMed · Cited by 177 · see citing works
Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus
Bonni, A., Frank, D. A., Schindler, C., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.7504325 · Cited by 177 · see citing works
Kim, H., & Baumann, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5326 · Cited by 170 · see citing works
Liu, C., Peng, M., Laties, A. M., & Wen, R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01337.1998 · Cited by 168 · see citing works
Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T., & Fukui, Y. (1997) · EMBO Journal · doi:10.1093/emboj/16.17.5345 · Cited by 157 · see citing works
MacLennan, A. J., Vinson, E. N., Marks, L., McLaurin, D., Pfeifer, M., & Lee, N. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00621.1996 · Cited by 148 · see citing works
Mechanical Injury Increases bFGF and CNTF mRNA Expression in the Mouse Retina
Cao, W., Wen, R., LI, F., LaVail, M. M., & Steinberg, R. H. (1997) · Experimental Eye Research · doi:10.1006/exer.1997.0328 · Cited by 147 · see citing works
Anderson, K. D., Panayotatos, N., Corcoran, T. L., Lindsay, R. M., & Wiegand, S. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7346 · Cited by 143 · see citing works
Self-citationKirsch, M., Lee, M., Meyer, V., Wiese, A., & Hofmann, H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68030979.x · Cited by 126 · see citing works
Wen, R., Cheng, T., Li, Y., Cao, W., & Steinberg, R. H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-05986.1996 · Cited by 116 · see citing works
Planas, A. M., Soriano, M. A., Berruezo, M., Justicia, C., Estrada, A., Pitarch, S., & Ferrer, I. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01556.x · Cited by 111 · see citing works
Wu, Y. Y., & Bradshaw, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13023 · Cited by 100 · see citing works
Herkenham, M. A., Lee, H. Y., & Baker, R. A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981019)400:2 · Cited by 87 · see citing works
Guérin, C. J., Anderson, D. H., & Fisher, S. K. (1990) · PubMed · Cited by 79 · see citing works
Raad, S. D., Szczesny, P. J., Munz, K., & Remé, C. E. (2009) · Ophthalmic Research · doi:10.1159/000267881 · Cited by 75 · see citing works
Expression of CNTF in Müller cells of the rat retina after pressure-induced ischemia
Ju, W., Lee, M., Hofmann, H., Kirsch, M., & Chun, M. (1999) · Neuroreport · doi:10.1097/00001756-199902050-00038 · Cited by 74 · see citing works
Guo, X., Chandrasekaran, V., Lein, P. J., Kaplan, P. L., & Higgins, D. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02113.1999 · Cited by 60 · see citing works
Panayotatos, N., Radziejewska, E., Acheson, A. L., Pearsall, D., Thadani, A., & Wong, V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46726-3 · Cited by 54 · see citing works
Peng, M., Li, Y., Luo, Z., Liu, C., Laties, A. M., & Wen, R. (1998) · PubMed · Cited by 53 · see citing works
Sawada, H., Kawamura, T., Shimohama, S., AKAIKE, A., & Kimura, J. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960215)43:4 · Cited by 52 · see citing works
LIF-mediated activation of STAT proteins after neuronal injury in vivo
Rajan, P., Stewart, C. L., & Fink, J. S. (1995) · Neuroreport · doi:10.1097/00001756-199511000-00033 · Cited by 44 · see citing works
Kirsch, M., & Hofmann, H. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90512-6 · Cited by 40 · see citing works
Chu, Y., Humphrey, M. F., Alder, V. A., & Constable, I. J. (1998) · Australian and New Zealand Journal of Ophthalmology · doi:10.1111/j.1442-9071.1998.tb01447.x · Cited by 36 · see citing works
C-fos gene expression in rat retinal cells after focal retinal injury.
Yoshida, K., Muraki, Y., Ohki, K., Harada, T., Ohashi, T., Matsuda, H., & Imaki, J. (1995) · PubMed · Cited by 29 · see citing works
Stat3 and NFκB glial expression after excitotoxic damage to the postnatal brain
Acarín, L., González, B., & Castellano, B. (1998) · Neuroreport · doi:10.1097/00001756-199808240-00035 · Cited by 23 · see citing works
Structure-function studies of human ciliary neurotrophic factor
Negro, A., Corsa, V., Corona, G., Grandi, C., Skaper, S. D., & Callegaro, L. (1994) · Neurochemical Research · doi:10.1007/bf00966820 · Cited by 8 · see citing works
Flagged first, then by citations
2 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The molecular basis of retinal ganglion cell death in glaucoma
Almasieh, M., Wilson, A. M., Morquette, B., Vargas, J. L. C., & Polo, A. D. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.002 · Cited by 974 · see citing works
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761 · see citing works
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack, D. R., & RAKIC, P. T. (2001) · Science · doi:10.1126/science.1065467 · Cited by 722 · see citing works
Pun, S., Santos, A. F., Saxena, S., Xu, L., & Caroni, P. (2006) · Nature Neuroscience · doi:10.1038/nn1653 · Cited by 659 · see citing works
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
Siveen, K. S., Sikka, S., Surana, R., Dai, X., Zhang, J., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.005 · Cited by 637 · see citing works
Sieving, P. A., Caruso, R. C., Tao, W., Coleman, H. R., Thompson, D. J. S., Fullmer, K. R., & Bush, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600236103 · Cited by 591 · see citing works
Wylie, R. G., Ahsan, S., Aizawa, Y., Maxwell, K. L., Morshead, C. M., & Shoichet, M. S. (2011) · Nature Materials · doi:10.1038/nmat3101 · Cited by 480 · see citing works
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
Wortley, K. E., Anderson, K. D., García, K., Murray, J. D., Malinova, L., Liu, R., Moncrieffe, M., Thabet, K., Cox, H. J., Yancopoulos, G. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402763101 · Cited by 471 · see citing works
Self-citationJAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Hu, Q., Bian, Q., Rong, D., Wang, L., Song, J., Huang, H.-S., Zeng, J., Mei, J., & Wang, P. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1110765 · Cited by 374 · see citing works
Levin, B. E., Dunn-Meynell, A. A., & Banks, W. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00393.2003 · Cited by 271 · see citing works
Regulation of autophagy by stress-responsive transcription factors
Pietrocola, F., Izzo, V., Niso‐Santano, M., Vacchelli, E., Galluzzi, L., Maiuri, M. C., & Kroemer, G. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.008 · Cited by 270 · see citing works
STAT3, stem cells, cancer stem cells and p63
Galoczová, M., Coates, P. J., & Vojtěšek, B. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0078-0 · Cited by 266 · see citing works
Lingor, P., Tönges, L., Pieper, N., Bermel, C., Barski, E., Planchamp, V., & Bähr, M. (2007) · Brain · doi:10.1093/brain/awm284 · Cited by 246 · see citing works
Cui, Q., Yip, H. K.-F., Zhao, R. C., So, K., & Harvey, A. R. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(02)00037-4 · Cited by 243 · see citing works
Sarapultsev, A., Gusev, E., Komelkova, M. V., Utepova, I. A., Luo, S., & Hu, D. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00151-1 · Cited by 226 · see citing works
Liang, F.-Q., Alemán, T. S., Dejneka, N. S., Dudus, L., Fisher, K. J., Maguire, A. M., Jacobson, S. G., & Bennett, J. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0473 · Cited by 221 · see citing works
Wen, R., Tao, W., Li, Y., & Sieving, P. A. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.005 · Cited by 214 · see citing works
Bok, D., Yasumura, D., Matthes, M. T., Ruíz, A., Duncan, J. L., Chappelow, A. V., Zolutukhin, S., Hauswirth, W. W., & LaVail, M. M. (2002) · Experimental Eye Research · doi:10.1006/exer.2002.1176 · Cited by 213 · see citing works
Ji, J., Elyaman, W., Yip, H. K.-F., Lee, V. W. H., Yick, L.-W., Hugon, J., & So, K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03107.x · Cited by 205 · see citing works
Kassen, S. C., Ramanan, V., Montgomery, J. E., T. Burket, C., Liu, C., Vihtelic, T. S., & Hyde, D. R. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20362 · Cited by 203 · see citing works
Neurotrophic factor control of satiety and body weight
Xu, B., & Xie, X. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.24 · Cited by 203 · see citing works
Regenerative medicine for retinal diseases: activating endogenous repair mechanisms
Karl, M., & Reh, T. A. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.02.003 · Cited by 200 · see citing works
Guo, Z., Jiang, H., Xu, X. Z. S., Duan, W., & Mattson, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703753200 · Cited by 202 · see citing works
Molecular determinants of retinal ganglion cell development, survival, and regeneration
Isenmann, S. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00027-2 · Cited by 192 · see citing works
(2002) · PubMed · Cited by 192 · see citing works
Au, N. P. B., & Ma, C. H. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.860070 · Cited by 187 · see citing works
Kretz, A., Hertler, C., Marticke, J. K., & Isenmann, S. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.009 · Cited by 184 · see citing works
Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF
Herde, A. M., Hauk, T. G., Leibinger, M., Marienfeld, R. B., & Fischer, D. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.03.002 · Cited by 176 · see citing works
Park, K. K., Luo, J.-M., Hisheh, S., Harvey, A. R., & Cui, Q. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3532-04.2004 · Cited by 168 · see citing works
Tam, R. Y., Smith, L. J., & Shoichet, M. S. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00543 · Cited by 166 · see citing works
Liang, F.-Q., Dejneka, N. S., Cohen, D. R., Krasnoperova, N. V., Lem, J., Maguire, A. M., Dudus, L., Fisher, K. J., & Bennett, J. (2001) · Molecular Therapy · doi:10.1006/mthe.2000.0252 · Cited by 167 · see citing works
Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma:
Horiguchi, A., Oya, M., Shimada, T., Uchida, A., Marumo, K., & Murai, M. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64741-6 · Cited by 166 · see citing works
Jacobi, A., Tran, N. M., Yan, W., Benhar, I., Tian, F., Schaffer, R., He, Z., & Sanes, J. R. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.002 · Cited by 154 · see citing works
Pernet, V., & Polo, A. D. (2006) · Brain · doi:10.1093/brain/awl015 · Cited by 160 · see citing works
Neuroprotective Effect of an Antioxidant, Lutein, during Retinal Inflammation
Sasaki, M., Ozawa, Y., Kurihara, T., Noda, K., Imamura, Y., Kobayashi, S., Ishida, S., & Tsubota, K. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2493 · Cited by 159 · see citing works
Zhao, X., Wan, J., Powell, C., Ramachandran, R., Myers, M. G., & Goldman, D. J. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.047 · Cited by 148 · see citing works
Wan, J., Zhao, X.-F., Vojtek, A., & Goldman, D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.048 · Cited by 143 · see citing works
“It is interesting that in mammals, β-catenin has been associated with a very limited amount of MG proliferation while pStat3 has been associated with injury-induced gliosis (Osakada et al., 2007; Peterson et al., 2000; Rhee et al., 2013; Xue et al., 2011).”
BackgroundErythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats.
Böcker-Meffert, S., Rosenstiel, P. C., Röhl, C., Warneke, N., Held‐Feindt, J., Sievers, J., & Lucius, R. (2002) · PubMed · Cited by 154 · see citing works
Promoting optic nerve regeneration
Fischer, D., & Leibinger, M. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.005 · Cited by 151 · see citing works
Ageeva, T., Rizvanov, A. A., & Mukhamedshina, Y. O. (2024) · Cells · doi:10.3390/cells13070581 · Cited by 151 · see citing works
Bramall, A. N., Wright, A. F., Jacobson, S. G., & McInnes, R. R. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153227 · Cited by 148 · see citing works
Signaling of Human Ciliary Neurotrophic Factor (CNTF) Revisited
Schuster, B., Kovaleva, M., Sun, Y. E., Regenhard, P., Matthews, V. B., Grötzinger, J., Rose‐John, S., & Kallen, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210044200 · Cited by 139 · see citing works
Suzuki, S., Tanaka, K., Nogawa, S., Dembo, T., Kosakai, A., & Fukuuchi, Y. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7701 · Cited by 138 · see citing works
Pernet, V., Joly, S., Dalkara, D., Jordi, N., Schwarz, O., Christ, F., Schaffer, D. V., Flannery, J. G., & Schwab, M. E. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.011 · Cited by 134 · see citing works
Yadav, A. K., Kalita, A., Dhillon, S., & Banerjee, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501316200 · Cited by 134 · see citing works
Horstmann, L., Schmid, H., Heinen, A. P., Kurschus, F. C., Dick, H. B., & Joachim, S. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-120 · Cited by 133 · see citing works
Jorstad, N. L., Wilken, M. S., Todd, L. J., Finkbeiner, C., Nakamura, P. A., Radulovich, N. P., Hooper, M. J., Chitsazan, A., Wilkerson, B. A., Rieke, F. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.075 · Cited by 129 · see citing works
Differential role of Jak‐STAT signaling in retinal degenerations
Samardzija, M., Wenzel, A., Aufenberg, S., Thiersch, M., Remé, C., & Grimm, C. (2006) · The FASEB Journal · doi:10.1096/fj.06-5895fje · Cited by 129 · see citing works
The role of glia in retinal vascular disease
Coorey, N. J., Shen, W., Chung, S. H., Zhu, L., & Gillies, M. C. (2012) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2012.00741.x · Cited by 130 · see citing works
Leibinger, M., Andreadaki, A., Diekmann, H., & Fischer, D. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.310 · Cited by 127 · see citing works
Kurihara, T., Ozawa, Y., Shinoda, K., Nagai, N., Inoue, M., Oike, Y., Tsubota, K., Ishida, S., & Okano, H. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0478 · Cited by 125 · see citing works
Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells
Tanaka, T., Yokoi, T., Tamalu, F., Watanabe, S., Nishina, S., & Azuma, N. (2015) · Scientific Reports · doi:10.1038/srep08344 · Cited by 121 · see citing works
Cui, Q. (2006) · Molecular Neurobiology · doi:10.1385/mn:33:2:155 · Cited by 130 · see citing works
Pernet, V., Joly, S., Jordi, N., Dalkara, D., Guzik-Kornacka, A., Flannery, J. G., & Schwab, M. E. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.266 · Cited by 119 · see citing works
Mitogen-Activated Protein Kinases and Retinal Ischemia
Roth, S., Shaikh, A. R., Hennelly, M. M., Li, Q., Bindokas, V., & Graham, C. E. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-0451 · Cited by 117 · see citing works
Kassen, S. C., Thummel, R., Campochiaro, L. A., Harding, M. J., Bennett, N. A., & Hyde, D. R. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.01.007 · Cited by 116 · see citing works
Loss of Inner Retinal Neurons After Retinal Ischemia in Rats
Schmid, H., Renner, M., Dick, H. B., & Joachim, S. C. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13372 · Cited by 114 · see citing works
van Adel, B. A., Kostic, C., Déglon, N., Ball, A. K., & Arsenijévic, Y. (2003) · Human Gene Therapy · doi:10.1089/104303403321070801 · Cited by 114 · see citing works
Ueki, Y., Wang, J., Chollangi, S., & Ash, J. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05180.x · Cited by 113 · see citing works
Turning Müller Glia into Neural Progenitors in the Retina
Fischer, A. J., & Bongini, R. E. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8152-2 · Cited by 111 · see citing works
Fischer, A. J., Scott, M. A., Ritchey, E. R., & Sherwood, P. (2009) · Glia · doi:10.1002/glia.20868 · Cited by 111 · see citing works
Trophic factors in the pathogenesis and therapy for retinal degenerative diseases
Kolomeyer, A. M., & Zarbin, M. A. (2014) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2013.09.004 · Cited by 114 · see citing works
Madhavan, L., Ourednik, V., & Ourednik, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0221 · Cited by 105 · see citing works
Targeting STAT3 in cancer and autoimmune diseases
Gharibi, T., Babaloo, Z., Hosseini, A., Abdollahpour‐Alitappeh, M., Hashemi, V., Marofi, F., Nejati‐Koshki, K., & Baradaran, B. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173107 · Cited by 104 · see citing works
Müller Glia in Retinal Innate Immunity: A Perspective on Their Roles in Endophthalmitis
Kumar, A., Pandey, R. K., Miller, L. J., Singh, P. K., & Kanwar, M. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013006618 · Cited by 99 · see citing works
The Acquisition of Target Dependence by Developing Rat Retinal Ganglion Cells
Moses, C., Wheeler, L. P. G., LeVaillant, C. J., Kramer, A. S., Ryan, M., Cozens, G. S., Sharma, A., Pollett, M. A., Rodger, J., & Harvey, A. R. (2015) · eNeuro · doi:10.1523/eneuro.0044-14.2015 · Cited by 103 · see citing works
Lee, N., Neitzel, K. L., Devlin, B. K., & MacLennan, A. J. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20140 · Cited by 99 · see citing works
Rhee, K. D., Nusinowitz, S., Chao, K., Yu, F., Bok, D., & Yang, X.-J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303604110 · Cited by 92 · see citing works
Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments
Ghanem, G. O. B., Wareham, L. K., & Calkins, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101261 · Cited by 97 · see citing works
Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor
Wen, R., Song, Y., Kjellström, S., Tanikawa, A., Liu, Y., Li, Y., Zhao, L., Bush, R. A., Laties, A. M., & Sieving, P. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4021-06.2006 · Cited by 89 · see citing works
Gao, N., Lee, P., & Yu, F. X. (2016) · Scientific Reports · doi:10.1038/srep36414 · Cited by 87 · see citing works
Todd, L. J., Squires, N. A., Suarez, L., & Fischer, A. J. (2016) · Scientific Reports · doi:10.1038/srep35703 · Cited by 87 · see citing works
Dutta, R., McDonough, J., Chang, A., Swamy, L., Siu, A., Kidd, G., Rudick, R., Mirnics, K., & Trapp, B. (2007) · Brain : a journal of neurology · doi:10.1093/brain/awm206 · Cited by 91 · see citing works
A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina
Gallina, D., Todd, L. J., & Fischer, A. J. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.019 · Cited by 84 · see citing works
The Complex Role of STAT3 in Viral Infections
Kuchipudi, S. V. (2015) · Journal of Immunology Research · doi:10.1155/2015/272359 · Cited by 84 · see citing works
Protein Phosphorylation Cascades Associated with Methamphetamine‐induced Glial Activation
Hebert, M. A., & O'Callaghan, J. P. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05200.x · Cited by 84 · see citing works
Müller Glia-Mediated Retinal Regeneration
Gao, H., Luodan, A., Huang, X., Chen, X., & Xu, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02274-w · Cited by 83 · see citing works
Watanabe, M., Tokita, Y., Kato, M. V., & Fukuda, Y. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00562-6 · Cited by 82 · see citing works
Cen, L., Luo, J.-M., Zhang, C., Fan, Y., Song, Y., So, K., van Rooijen, N., Pang, C. P., Lam, D. S. C., & Cui, Q. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0791 · Cited by 82 · see citing works
Peptide YY Regulates Bone Turnover in Rodents
Wortley, K. E., García, K., Okamoto, H., Thabet, K., Anderson, K. D., Shen, V., Herman, J. P., Valenzuela, D. M., Yancopoulos, G. D., Tschöp, M. H., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.024 · Cited by 82 · see citing works
Gene therapy for retinal ganglion cell neuroprotection in glaucoma
Wilson, A. M., & Polo, A. D. (2011) · Gene Therapy · doi:10.1038/gt.2011.142 · Cited by 81 · see citing works
Fischer, A. J., Schmidt, M., Omar, G., & Reh, T. A. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.08.007 · Cited by 81 · see citing works
van Adel, B. A., Arnold, J. M., Phipps, J., Doering, L. C., & Ball, A. K. (2005) · Journal of Neurobiology · doi:10.1002/neu.20117 · Cited by 80 · see citing works
Intraocular CNTF Reduces Vision in Normal Rats in a Dose-Dependent Manner
McGill, T. J., Prusky, G. T., Douglas, R. M., Yasumura, D., Matthes, M. T., Nune, G. C., Donohue–Rolfe, K. M., Yang, H., Niculescu, D., Hauswirth, W. W., et al. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0054 · Cited by 77 · see citing works
Distribution of OX2 antigen and OX2 receptor within retina.
Dick, A. D., Broderick, C. A., Forrester, J. V., & Wright, G. J. (2001) · PubMed · Cited by 75 · see citing works
Rhee, K. D., Goureau, O., Chen, S., & Yang, X.-J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1785-04.2004 · Cited by 75 · see citing works
Horinaga, M., Okita, H., Nakashima, J., Kanao, K., Sakamoto, M., & Murai, M. (2005) · Urology · doi:10.1016/j.urology.2005.03.066 · Cited by 73 · see citing works
Zacks, D. N., Han, Y., Zeng, Y., & Swaroop, A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1209 · Cited by 73 · see citing works
Ortín-Martínez, A., Valiente‐Soriano, F. J., García‐Ayuso, D., Alarcón-Martínez, L., Jiménez-López, M., Bernal-Garro, J. M., Nieto-López, L., Nadal-Nicolás, F. M., Villegas‐Pérez, M. P., Wheeler, L. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113798 · Cited by 72 · see citing works
CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa
Lipinski, D. M., Barnard, A. R., Singh, M. S., Martin, C. J., Lee, E., Davies, W. I. L., & MacLaren, R. E. (2015) · Molecular Therapy · doi:10.1038/mt.2015.68 · Cited by 73 · see citing works
Harada, T., Harada, C., Wang, Y.-L., Osaka, H., Amanai, K., Tanaka, K., Takizawa, S., Setsuie, R., Sakurai, M., Sato, Y., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63096-9 · Cited by 73 · see citing works
Xie, L., Yin, Y., & Benowitz, L. I. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017282118 · Cited by 72 · see citing works
Rhee, K. D., Ruíz, A., Duncan, J. L., Hauswirth, W. W., LaVail, M. M., Bok, D., & Yang, X.-J. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0677 · Cited by 72 · see citing works
Neurotrophic Signaling in Normal and Degenerating Rodent Retinas
Wahlin, K. J., Adler, R., Zack, D. J., & Campochiaro, P. A. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1078 · Cited by 72 · see citing works
Reis, R. A. D. M., Ventura, A. L. M., Schitine, C., de Mello, M. C. F., & Mello, F. G. D. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9604-1 · Cited by 70 · see citing works
Maier, K., Rau, C. R., Storch, M., Sättler, M. B., Demmer, I., Weissert, R., Taheri, N., Kuhnert, A., Bähr, M., & Diem, R. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00081.x · Cited by 74 · see citing works
Zhang, S. S.-M., Liu, M.-G., Kano, A., Zhang, C., Fu, X.-Y., & Barnstable, C. J. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.016 · Cited by 68 · see citing works
Expression profiling identifies strain‐specific changes associated with ethanol withdrawal in mice
Daniels, G. M., & Buck, K. J. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00008.x · Cited by 67 · see citing works
Valter, K., Bisti, S., Gargini, C., Loreto, S. D., Maccarone, R., Cervetto, L., & Stone, J. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0657 · Cited by 66 · see citing works
Grillo, C. A., Piroli, G. G., Junor, L., Wilson, S. P., Mott, D. D., Wilson, M. A., & Reagan, L. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.028 · Cited by 64 · see citing works
- Authors
- Peterson, W. M., Wang, Q., Tzekova, R., & Wiegand, S. J.
- Affiliations
- Regeneron (United States) (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-06-01
- Volume
- 20
- Issue
- 11
- Pages
- 4081-4090
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772642
- OpenAlex
- W1493793044
- Cited by
- 267
- References
- 59
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 16 · 2012: 13
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- ciliary neurotrophic factor, JAK/STAT signaling, STAT3, STAT1, retinal neurons, retinal glia, retinal ganglion cells, photoreceptors, Müller cells, astrocytes, RAS/MAPK pathway, light-induced retinal degeneration, xylazine, mechanical trauma, neuroprotection
- MeSH terms
- Animals, Conditioning, Psychological, DNA-Binding Proteins, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Male, Nerve Tissue Proteins, Neuroglia, Neurons, Phosphorylation, Photic Stimulation, Retina, Stress, Psychological, Transcription, Genetic, Signal Transduction, Trans-Activators, Rats, Sprague-Dawley, MAP Kinase Kinase Kinases, Ciliary Neurotrophic Factor, Extracellular Signal-Regulated MAP Kinases, STAT3 Transcription Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
