The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse
Open accessAbstract
Activation of either adenosine A1 receptors or GABAB receptors inhibits many excitatory synapses in the mammalian brain. However, the extent to which different mechanisms contribute to such synaptic modulation is unclear. We examined the manner in which activation of adenosine A1 receptors and GABAB receptors modulates synaptic strength at the granule cell to Purkinje cell synapse in rat cerebellar slices. Optical determination of presynaptic calcium influx revealed that presynaptic calcium channels were modulated by 2-chloroadenosine (2CA) and baclofen, agonists of the adenosine A1 receptor and the GABAB receptor, respectively. 2CA and baclofen differentially affected three classes of calcium channels without altering the shape of the presynaptic volley, suggesting that changes in presynaptic waveform do not contribute significantly to synaptic modulation. 2CA affected neither the amplitude nor the frequency of spontaneous miniature postsynaptic currents, whereas baclofen reduced the frequency by approximately 40% without affecting the amplitude. In addition, 2CA and baclofen do not change either fiber excitability or presynaptic residual calcium. Taken together, our data indicate that activation of the adenosine A1 receptor reduces synaptic strength by modulating presynaptic calcium channels. Baclofen modulates presynaptic calcium channels as well but also affects release processes downstream from calcium entry.
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Cites
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Self-citationEnhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons
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Cited by
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
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Presynaptic Calcium Current Modulation by a Metabotropic Glutamate Receptor
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Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1α
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Self-citationCholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus
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Metadata
- Authors
- Dittman, J., & Regehr, W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-03-01
- Volume
- 16
- Issue
- 5
- Pages
- 1623-1633
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1571745125
- Cited by
- 275
- References
- 41
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dittman, J., & Regehr, W. (1996). Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.16-05-01623.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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