The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein
Open accessAbstract
Nitric oxide (NO) formation in brain is regulated by the calcium/calmodulin dependence of neuronal NO synthase (nNOS). Calcium influx through NMDA-type glutamate receptors is efficiently coupled to nNOS activity, whereas many other intracellular calcium pathways are poorly coupled. To elucidate possible mechanisms responsible for this coupling, we performed yeast two-hybrid screening to identify proteins that interact with nNOS. Two nNOS interacting proteins were identified: the postsynaptic density proteins PSD-93 and PSD-95. Here, we report the cloning and characterization of PSD-93. PSD-93 is expressed in discrete neuronal populations as well as in specific non-neuronal cells, and it exhibits complex molecular diversity attributable to tissue-specific alternative splicing. PSD-93, like PSD-95, binds to nNOS and to the NMDA receptor 2B. PSD-93, however, is unique among PSD-95/SAP-90 family members in its expression in Purkinje neuron cell bodies and dendrites. We also demonstrate that the PDZ domain at the N terminus of nNOS is required, but it is not sufficient for interaction with PSD-93/95. Given that PSD-93 and PSD-95 each contain multiple potential binding sites for nNOS and the NMDA receptor, complexes involving oligomers of PSD-93/95 may help account for the functional as well as the physical coupling of nNOS to NMDA receptors.
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Cites
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Metadata
- Authors
- Brenman, J. E., Christopherson, K. S., Craven, S. E., McGee, A. W., & Bredt, D. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-12-01
- Volume
- 16
- Issue
- 23
- Pages
- 7407-7415
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1532490237
- Cited by
- 332
- References
- 36
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Brenman, J. E., Christopherson, K. S., Craven, S. E., McGee, A. W., & Bredt, D. S. (1996). Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.16-23-07407.1996
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