Central sensitization: a generator of pain hypersensitivity by central neural plasticity

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

Neuronal plasticity: Increasing the gain in pain

Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 5× · see citing works

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

Conn, P. J., & Pin, J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.205 · Cited by 3,083 · see citing works

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,906 · see citing works

Functional imaging of brain responses to pain. A review and meta-analysis (2000)

Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171 · see citing works

Evidence for a central component of post-injury pain hypersensitivity

Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157 · see citing works

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986 · see citing works

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

Woolf, C. J., & Thompson, S. (1991) · Pain · doi:10.1016/0304-3959(91)90100-c · Cited by 1,985 · see citing works

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965 · see citing works

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896 · see citing works

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

Kornau, H., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995) · Science · doi:10.1126/science.7569905 · Cited by 1,882 · see citing works

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

Brenman, J. E., Chao, D. S., Gee, S., McGee, A. W., Craven, S. E., Santillano, D. R., Wu, Z., Huang, F., Xia, H., Peters, M. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81053-3 · Cited by 1,596 · see citing works

PDZ domain proteins of synapses

Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,566 · see citing works

Mechanisms of neuropathic pain

Campbell, J. N., & Meyer, R. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.021 · Cited by 1,471 · see citing works

Central sensitization and LTP: do pain and memory share similar mechanisms?

Ji, R., Kohno, T., Moore, K. A., & Woolf, C. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.017 · Cited by 1,462 · see citing works

Pathological and protective roles of glia in chronic pain

Milligan, E. D., & Watkins, L. R. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2533 · Cited by 1,404 · see citing works

Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282 · see citing works

TRPA1 mediates formalin-induced pain

McNamara, C. R., Mandel-Brehm, J., Bautista, D. M., Siemens, J., Deranian, K. L., Zhao, M. A., Hayward, N. J., Chong, J. A., Julius, D. J., Moran, M. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705924104 · Cited by 1,270 · see citing works

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

Kawasaki, Y., Zhang, L., Cheng, J.-K., & Ji, R.-R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3338-07.2008 · Cited by 1,162 · see citing works

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159 · see citing works

Mechanisms and functions of eph and ephrin signalling

Kullander, K., & Klein, R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm856 · Cited by 1,158 · see citing works

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

Coull, J. A. M., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Attila Gabor, S. I. K., Koninck, P. D., & Koninck, Y. D. (2003) · Nature · doi:10.1038/nature01868 · Cited by 1,118 · see citing works

Homer: a protein that selectively binds metabotropic glutamate receptors

Brakeman, P., Lanahan, A. A., O’Brien, R., Roche, K. W., Barnes, C. A., Huganir, R. L., & Worley, P. F. (1997) · Nature · doi:10.1038/386284a0 · Cited by 1,115 · see citing works

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works

Glial activation: a driving force for pathological pain

Watkins, L. R., Milligan, E. D., & Maier, S. F. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01854-3 · Cited by 1,091 · see citing works

Peripheral nerve injury triggers central sprouting of myelinated afferents

Woolf, C. J., Shortland, P. J., & Coggeshall, R. E. (1992) · Nature · doi:10.1038/355075a0 · Cited by 1,083 · see citing works

Nociceptors—Noxious Stimulus Detectors

Woolf, C. J., & Ma, Q. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.016 · Cited by 1,053 · see citing works

Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,047 · see citing works

Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009 · see citing works

MAP kinase and pain

Ji, R., Gereau, R. W., Malcangio, M., & Strichartz, G. R. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.011 · Cited by 993 · see citing works

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

Chen, L., & Huang, L.-Y. M. (1992) · Nature · doi:10.1038/356521a0 · Cited by 964 · see citing works

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

LaMotte, R. H., Shain, C. N., Simone, D. A., & Tsai, E. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.190 · Cited by 936 · see citing works

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

Esteban, J. A., Shi, S.-H., Wilson, C., Nuriya, M., Huganir, R. L., & Malinow, R. (2003) · Nature Neuroscience · doi:10.1038/nn997 · Cited by 894 · see citing works

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

Dong, H., O’Brien, R., Fung, E. T., Lanahan, A. A., Worley, P. F., & Huganir, R. L. (1997) · Nature · doi:10.1038/386279a0 · Cited by 871 · see citing works

Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors

Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862 · see citing works

Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

Moore, K. A., Kohno, T., Karchewski, L. A., Scholz, J., Baba, H., & Woolf, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06724.2002 · Cited by 859 · see citing works

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

Dickenson, A. H., & Sullivan, A. F. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90275-9 · Cited by 845 · see citing works

Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

Vasudeva, R., Tanga, F. Y., & DeLeo, J. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052407 · Cited by 797 · see citing works

Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

Torebjörk, H. E., Lundberg, L. E. R., & LaMotte, R. H. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019069 · Cited by 785 · see citing works

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

Ji, R., Baba, H., Brenner, G. J., & Woolf, C. J. (1999) · Nature Neuroscience · doi:10.1038/16040 · Cited by 782 · see citing works

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhuang, Z., Gerner, P., Woolf, C. J., & Ji, R. (2005) · Pain · doi:10.1016/j.pain.2004.12.022 · Cited by 774 · see citing works

Src kinases: a hub for NMDA receptor regulation

Salter, M. W., & Kalia, L. V. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1368 · Cited by 767 · see citing works

Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States

Watkins, L. R., & Maier, S. F. (2002) · Physiological Reviews · doi:10.1152/physrev.00011.2002 · Cited by 733 · see citing works

EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation

Dalva, M. B., Takasu, M. A., Lin, M. Z., Shamah, S. M., Hu, L. S., Gale, N. W., & Greenberg, M. E. (2000) · Cell · doi:10.1016/s0092-8674(00)00197-5 · Cited by 716 · see citing works

Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer

Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 691 · see citing works

Activation of CaMKII in single dendritic spines during long-term potentiation

Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685 · see citing works

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

Ledeboer, A., Sloane, E. M., Milligan, E. D., Frank, M. G., Mahony, J. H., Maier, S. F., & Watkins, L. R. (2005) · Pain · doi:10.1016/j.pain.2005.02.009 · Cited by 677 · see citing works

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

Yaksh, T. L. (1989) · Pain · doi:10.1016/0304-3959(89)90160-7 · Cited by 673 · see citing works

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

Davies, S. N., & Lodge, D. (1987) · Brain Research · doi:10.1016/0006-8993(87)91487-9 · Cited by 668 · see citing works

Effects of substance P on functionally identified units in cat spinal cord

Henry, J. L. (1976) · Brain Research · doi:10.1016/0006-8993(76)90965-3 · Cited by 660 · see citing works

Synaptic plasticity at hippocampal mossy fibre synapses

Nicoll, R. A., & Schmitz, D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1786 · Cited by 653 · see citing works

Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase

Banke, T. G., Bowie, D., Lee, H.-K., Huganir, R. L., Schousboe, A., & Traynelis, S. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00089.2000 · Cited by 652 · see citing works

Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins

Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A. M., Lanahan, A. A., Wenthold, R. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80588-7 · Cited by 649 · see citing works

Spinal cord mechanisms of pain

D’Mello, R., & Dickenson, A. H. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen088 · Cited by 642 · see citing works

The role of neuroinflammation and neuroimmune activation in persistent pain

DeLeo, J. A., & Yezierski, R. P. (2001) · Pain · doi:10.1016/s0304-3959(00)00490-5 · Cited by 639 · see citing works

Calcium stores regulate the polarity and input specificity of synaptic modification

Nishiyama, M., Hong, K., Mikoshiba, K., Poo, M.-M., & Kato, K. (2000) · Nature · doi:10.1038/35046067 · Cited by 635 · see citing works

Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor

Mantyh, P. W., Rogers, S. D., Honoré, P., Allen, B. J., Ghilardi, J. R., Li, J., Daughters, R. S., Lappi, D. A., Wiley, R. G., & Simone, D. A. (1997) · Science · doi:10.1126/science.278.5336.275 · Cited by 634 · see citing works

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

Tanga, F. Y., Nutile-McMenemy, N., & DeLeo, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501634102 · Cited by 634 · see citing works

p38 MAPK, Microglial Signaling, and Neuropathic Pain

Ji, R., & Suter, M. R. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-33 · Cited by 626 · see citing works

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

Simone, D. A., Sorkin, L. S., Oh, U. T., Chung, J. M., Owens, C. M., LaMotte, R. H., & Willis, W. D. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.228 · Cited by 625 · see citing works

GlyR α3: An Essential Target for Spinal PGE 2 -Mediated Inflammatory Pain Sensitization

Harvey, R. J., Depner, U. B., Wässle, H., Ahmadi, S., Heindl, C., Reinold, H., Smart, T. G., Harvey, K., Schütz, B., Abo‐Salem, O. M., et al. (2004) · Science · doi:10.1126/science.1094925 · Cited by 623 · see citing works

Chemical Stimulation of the Intracranial Dura Induces Enhanced Responses to Facial Stimulation in Brain Stem Trigeminal Neurons

Burstein, R., Yamamura, H., Malick, A., & Strassman, A. M. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.964 · Cited by 607 · see citing works

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

LaMotte, R. H., Lundberg, L. E. R., & Torebjörk, H. E. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019068 · Cited by 593 · see citing works

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

Abbadie, C., Lindia, J. A., Cumiskey, A. M., Peterson, L., Mudgett, J. S., Bayne, E. K., DeMartino, J. A., MacIntyre, D. E., & Forrest, M. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1331358100 · Cited by 591 · see citing works

The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking

Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590 · see citing works

Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres

Mendell, L. M., & Wall, P. D. (1965) · Nature · doi:10.1038/206097a0 · Cited by 586 · see citing works

Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons

Honoré, P., Rogers, S. D., Schwei, M. J., Salak‐Johnson, J. L., Luger, N. M., Sabino, M. C., Clohisy, D. R., & Mantyh, P. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00110-x · Cited by 585 · see citing works

Novel Effects of Nitric Oxide

Davis, K. L., Martin, E., Turko, I. V., & Murad, F. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.203 · Cited by 585 · see citing works

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons

Neumann, S., Doubell, T. P., Leslie, T. A., & Woolf, C. J. (1996) · Nature · doi:10.1038/384360a0 · Cited by 584 · see citing works

Complete Freunds adjuvant‐induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS

Vasudeva, R., Tanga, F. Y., & DeLeo, J. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03514.x · Cited by 582 · see citing works

The mouse stargazer gene encodes a neuronal Ca2+-channel γ subunit

Letts, V. A., Felix, R., Biddlecome, G. H., Arikkath, J., Mahaffey, C. L., Valenzuela, A., Bartlett, F. S., Mori, Y., Campbell, K. P., & Frankel, W. N. (1998) · Nature Genetics · doi:10.1038/1228 · Cited by 578 · see citing works

Pain pathways and parabrachial circuits in the rat.

Gauriau, C., & Bernard, J. (2002) · Experimental Physiology · doi:10.1113/eph8702357 · Cited by 572 · see citing works

Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia

Ikeda, H., Heinke, B., Ruscheweyh, R., & Sandkühler, J. (2003) · Science · doi:10.1126/science.1080659 · Cited by 569 · see citing works

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

Gao, Y., Zhang, L., Samad, O. A., Suter, M. R., Kawasaki, Y., Xu, Z., Park, J. Y., Lind, A., Ma, Q., & Ji, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3623-08.2009 · Cited by 569 · see citing works

Neurophysiologic evidence for a central sensitization in patients with fibromyalgia

Desmeules, J. A., Cedraschi, C., Rapiti, E., Baumgartner, E., Finckh, A., Cohen, P., Dayer, P., & VISCHER, T. L. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10893 · Cited by 561 · see citing works

Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins

Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558 · see citing works

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.

Costigan, M., Befort, K., Karchewski, L. A., Griffin, R. S., D’Urso, D., Allchorne, A. J., Sitarski, J., Mannion, J. W., Pratt, R. E., & Woolf, C. J. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-16 · Cited by 553 · see citing works

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

Tegeder, I., Costigan, M., Griffin, R. S., Abele, A., Belfer, I., Schmidt, H., Ehnert, C., Nejim, J. A., Marian, C., Scholz, J., et al. (2006) · Nature Medicine · doi:10.1038/nm1490 · Cited by 548 · see citing works

NSF Binding to GluR2 Regulates Synaptic Transmission

Nishimune, A., Isaac, J. T. R., Molnár, E., Noël, J., Nash, S. R., Tagaya, M., Collingridge, G. L., Nakanishi, S., & Henley, J. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80517-6 · Cited by 544 · see citing works

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

Tomita, S., Chen, L., Kawasaki, Y., Petralia, R. S., Wenthold, R. J., Nicoll, R. A., & Bredt, D. S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212116 · Cited by 527 · see citing works

Dynamic and static components of mechanical hyperalgesia in human hairy skin

Koltzenburg, M., Lundberg, L. E. R., & Torebjörk, E. H. (1992) · Pain · doi:10.1016/0304-3959(92)90262-a · Cited by 523 · see citing works

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

Kim, E., Naisbitt, S., Hsueh, Y.-P., Rao, A., Rothschild, A., Craig, A. M., & Sheng, M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.3.669 · Cited by 516 · see citing works

Muscle but not cutaneous C‐afferent input produces prolonged increases in the excitability of the flexion reflex in the rat.

Wall, P. D., & Woolf, C. J. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015475 · Cited by 513 · see citing works

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain

Xiao, H., Huang, Q., Zhang, F., Bao, L., Lu, Y., Guo, C., Yang, L., Huang, W.-J., Fu, G., Xu, S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122231899 · Cited by 501 · see citing works

Modulation of NMDA Receptor- Dependent Calcium Influx and Gene Expression Through EphB Receptors

Takasu, M. A., Dalva, M. B., Zigmond, R. E., & Greenberg, M. E. (2002) · Science · doi:10.1126/science.1065983 · Cited by 497 · see citing works

Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies

Tingley, W. G., Ehlers, M., Kameyama, K., Doherty, C., Ptak, J., Riley, C. T., & Huganir, R. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.8.5157 · Cited by 496 · see citing works

Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology

Hucho, T. B., & Levine, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.008 · Cited by 491 · see citing works

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J. R., Nicoll, R. A., & Bredt, D. S. (2005) · Nature · doi:10.1038/nature03624 · Cited by 486 · see citing works

The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1

Petralia, R., Wang, Y., & Wenthold, R. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06102.1994 · Cited by 481 · see citing works

The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord

Sivilotti, L., & Woolf, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.1.169 · Cited by 468 · see citing works

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467 · see citing works

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

Baumann, T., Simone, D. A., Shain, C. N., & LaMotte, R. H. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.212 · Cited by 456 · see citing works

Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn

Ikeda, H., Stark, J., Fischer, H., Wagner, M. W., Drdla-Schutting, R., Jäger, T., & Sandkühler, J. (2006) · Science · doi:10.1126/science.1127233 · Cited by 451 · see citing works

Brain-Derived Neurotrophic Factor Modulates Nociceptive Sensory Inputs and NMDA-Evoked Responses in the Rat Spinal Cord

Kerr, B. J., Bradbury, E. J., Bennett, D., Trivedi, P. M., Dassan, P., French, J., Shelton, D., McMahon, S. B., & Thompson, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05138.1999 · Cited by 442 · see citing works

Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways

Suzuki, R., Morcuende, S., Webber, M., Hunt, S. P., & Dickenson, A. H. (2002) · Nature Neuroscience · doi:10.1038/nn966 · Cited by 442 · see citing works

The role of calmodulin as a signal integrator for synaptic plasticity

Xia, Z., & Storm, D. R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1647 · Cited by 441 · see citing works

Spontaneous Pain, Both Neuropathic and Inflammatory, Is Related to Frequency of Spontaneous Firing in Intact C-Fiber Nociceptors

Djouhri, L., Koutsikou, S., Fang, X., McMullan, S., & Lawson, S. N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3388-05.2006 · Cited by 440 · see citing works

Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury

Scholz, J., Broom, D. C., Youn, D. H., Mills, C. D., Kohno, T., Suter, M. R., Moore, K. A., Décosterd, I., Coggeshall, R. E., & Woolf, C. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-05.2005 · Cited by 437 · see citing works

Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

Mannion, R., Costigan, M., Décosterd, I., Amaya, F., Ma, Q., Holstege, J. C., Ji, R., Acheson, A. L., Lindsay, R. M., Wilkinson, G. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9385 · Cited by 435 · see citing works

Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord

Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407 · see citing works

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 398 · see citing works

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

Schwenk, J., Harmel, N., Zolles, G., Bildl, W., Kulik, Á., Heimrich, B., Chisaka, O., Jónás, P., Schulte, U., Fakler, B., et al. (2009) · Science · doi:10.1126/science.1167852 · Cited by 388 · see citing works

Regulation of NMDA receptors by phosphorylation

Chen, B.-S., & Roche, K. W. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.018 · Cited by 386 · see citing works

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

Verge, G. M., Milligan, E. D., Maier, S. F., Watkins, L. R., Naeve, G. S., & Foster, A. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03593.x · Cited by 386 · see citing works

Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization

Kawasaki, Y., Kohno, T., Zhuang, Z.-Y., Brenner, G. J., Wang, H., Meer, C. V. D., Befort, K., Woolf, C. J., & Ji, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2396-04.2004 · Cited by 386 · see citing works

Activation of p38 mitogen‐activated protein kinase in spinal microglia is a critical link in inflammation‐induced spinal pain processing

Svensson, C. I., Maršala, M., Westerlund, A., Calcutt, N. A., Campana, W. M., Freshwater, J. D., Catalano, R., Feng, Y. J., Protter, A. A., Scott, B. T., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01969.x · Cited by 385 · see citing works

Metabotropic Glutamate Receptor Subtypes 1 and 5 Are Activators of Extracellular Signal-Regulated Kinase Signaling Required for Inflammatory Pain in Mice

Karim, F., Wang, C., & Gereau, R. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03771.2001 · Cited by 384 · see citing works

Ectopic discharge in Aβ afferents as a source of neuropathic pain

Devor, M. G. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1724-6 · Cited by 384 · see citing works

Neuroinflammation and regulation of glial glutamate uptake in neurological disorders

Tilleux, S., & Hermans, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21325 · Cited by 381 · see citing works

Windup and central sensitization are not equivalent

Woolf, C. J. (1996) · Pain · doi:10.1097/00006396-199608000-00001 · Cited by 381 · see citing works

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N -methyl- d -aspartate receptor subunit NR2A

Tezuka, T., Umemori, H., Akiyama, T., Nakanishi, S., & Yamamoto, T. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.435 · Cited by 377 · see citing works

The 5-HT 3 Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors

Zeitz, K. P., Guy, N., Malmberg, A. B., Dirajlal, S., Martin, W. J., Sun, L. M., Bonhaus, D. W., Stucky, C. L., Julius, D. J., & Basbaum, A. I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01010.2002 · Cited by 376 · see citing works

SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit

Leonard, A. S., Davare, M. A., Horne, M. C., Garner, C. C., & Hell, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19518 · Cited by 374 · see citing works

Understanding LTP in Pain Pathways

Sandkühler, J. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-9 · Cited by 359 · see citing works

Analgesic triptan action in an animal model of intracranial pain: A race against the development of central sensitization

Burstein, R., & Jakubowski, M. (2003) · Annals of Neurology · doi:10.1002/ana.10785 · Cited by 358 · see citing works

Spatial and temporal relationship between monocyte chemoattractant protein‐1 expression and spinal glial activation following peripheral nerve injury

Zhang, J., & Koninck, Y. D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03746.x · Cited by 345 · see citing works

Contribution of central sensitisation to the development of noncardiac chest pain

Sarkar, S., Aziz, Q., Woolf, C. J., Hobson, A. R., & Thompson, D. G. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02758-6 · Cited by 345 · see citing works

Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs

Tomita, S., Stein, V., Stocker, T. J., Nicoll, R. A., & Bredt, D. S. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.009 · Cited by 343 · see citing works

Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein

Brenman, J. E., Christopherson, K. S., Craven, S. E., McGee, A. W., & Bredt, D. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07407.1996 · Cited by 333 · see citing works

Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISAIn Situ

Bałkowiec, A., & Katz, D. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07417.2000 · Cited by 332 · see citing works

Brain-Derived Neurotrophic Factor Increases in the Uninjured Dorsal Root Ganglion Neurons in Selective Spinal Nerve Ligation Model

Fukuoka, T., Kondo, E., Dai, Y., Hashimoto, N., & Noguchi, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04891.2001 · Cited by 325 · see citing works

The Homer family proteins.

Shiraishi‐Yamaguchi, Y., & Furuichi, T. (2007) · Genome biology · doi:10.1186/gb-2007-8-2-206 · Cited by 324 · see citing works

Induction of long‐term potentiation at spinal synapses by noxious stimulation or nerve injury

Sandkühler, J., & Liu, X. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00278.x · Cited by 318 · see citing works

PGE2 selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons

Ahmadi, S., Lippross, S., Neuhuber, W., & Zeilhofer, H. U. (2001) · Nature Neuroscience · doi:10.1038/nn778 · Cited by 314 · see citing works

Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit

Man, H.-Y., Sekine-Aizawa, Y., & Huganir, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611698104 · Cited by 311 · see citing works

Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord

Thompson, S., Bennett, D., Kerr, B. J., Bradbury, E. J., & McMahon, S. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7714 · Cited by 306 · see citing works

Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor

Omkumar, R. V., Kiely, M. J., Rosenstein, A. J., Min, K.-T., & Kennedy, M. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31670 · Cited by 304 · see citing works

Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity

Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300 · see citing works

Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons

Noguchi, K., Kawai, Y., Fukuoka, T., Senba, E., & Miki, K. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07633.1995 · Cited by 299 · see citing works

Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism

Noël, J., Ralph, G. S., Pickard, L., Williams, J., Molnár, E., Uney, J. B., Collingridge, G. L., & Henley, J. M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80786-2 · Cited by 299 · see citing works

Observations on the scratch‐reflex in the spinal dog

Sherrington, C. (1906) · The Journal of Physiology · doi:10.1113/jphysiol.1906.sp001139 · Cited by 298 · see citing works

Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat

Woolf, C. J., & Wiesenfeld‐Hallin, Z. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90195-3 · Cited by 294 · see citing works

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats

Milligan, E. D., Zapata, V., Chacur, M., Schoeniger, D., Biedenkapp, J. C., O’Connor, K., Verge, G. M., Chapman, G. A., Green, P., Foster, A. C., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03709.x · Cited by 289 · see citing works

Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression

Steinberg, J. P., Takamiya, K., Shen, Y., Xia, J., Rubio, M. E., Yu, S., Jin, W., Thomas, G. M., Linden, D. J., & Huganir, R. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.025 · Cited by 288 · see citing works

Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of n-methyl-d-aspartic acid and substance P

Dougherty, P. M., & Willis, W. D. (1991) · Pain · doi:10.1016/0304-3959(91)90015-p · Cited by 284 · see citing works

Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-d-aspartic acid receptor blockage

Liu, X., & Sandkühler, J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11553-0 · Cited by 280 · see citing works

Recent advances in understanding migraine mechanisms, molecules and therapeutics

Goadsby, P. J. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.11.005 · Cited by 279 · see citing works

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

Fagni, L., Chavis, P., Ango, F., & Bockaert, J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01492-7 · Cited by 279 · see citing works

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

Woolf, C., & King, A. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02717.1990 · Cited by 278 · see citing works

β-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase

Raman, I. M., Tong, G., & Jahr, C. E. (1996) · Neuron · doi:10.1016/s0896-6273(00)80059-8 · Cited by 278 · see citing works

Chemokines and pain mechanisms

Abbadie, C., Bhangoo, S. K., Koninck, Y. D., Malcangio, M., Parsadaniantz, S. M., & White, F. A. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.002 · Cited by 278 · see citing works

Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy

Woolf, C. J., Shortland, P. J., Reynolds, M. L., Ridings, J., Doubell, T. P., & Coggeshall, R. E. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600109 · Cited by 278 · see citing works

Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons

Zhou, X., & Rush, R. A. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00237-0 · Cited by 277 · see citing works

Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn

Baba, H., Ji, R., Kohno, T., Moore, K. A., Ataka, T., Wakai, A., Okamoto, M., & Woolf, C. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00236-7 · Cited by 274 · see citing works

Cyclic AMP-dependent Protein Kinase and Protein Kinase C Phosphorylate N-Methyl-d-aspartate Receptors at Different Sites

Leonard, A. S., & Hell, J. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12107 · Cited by 273 · see citing works

Activity‐Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a D‐2‐Amino‐5‐Phosphonovaleric Acid Sensitive Windup

Thompson, S., King, A. E., & Woolf, C. J. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00453.x · Cited by 270 · see citing works

Pathophysiology of damaged nerves in relation to chronic pain

Devor, M. (1999) · Medical Entomology and Zoology · Cited by 265 · see citing works

Differential migration, LPS‐induced cytokine, chemokine, and NO expression in immortalized BV‐2 and HAPI cell lines and primary microglial cultures

Horvath, R. J., Nutile‐McMenemy, N., Alkaitis, M. S., & DeLeo, J. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05633.x · Cited by 264 · see citing works

Phosphorylation of Serine‐880 in GluR2 by Protein Kinase C Prevents Its C Terminus from Binding with Glutamate Receptor‐Interacting Protein

Matsuda, S., Mikawa, S., & Hirai, H. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731765.x · Cited by 263 · see citing works

Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

Vasudeva, R., Tanga, F. Y., Rutkowski, M. D., & DeLeo, J. A. (2003) · Pain · doi:10.1016/s0304-3959(03)00138-6 · Cited by 259 · see citing works

The Kv4.2 Potassium Channel Subunit Is Required for Pain Plasticity

Hu, H., Carrasquillo, Y., Karim, F., Jung, W. E., Nerbonne, J. M., Schwarz, T. L., & Gereau, R. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.010 · Cited by 257 · see citing works

JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat

Dominguez, E., Rivat, C., Pommier, B., Mauborgne, A., & Pohl, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05566.x · Cited by 256 · see citing works

Synaptic Plasticity in the Amygdala in a Model of Arthritic Pain: Differential Roles of Metabotropic Glutamate Receptors 1 and 5

Neugebauer, V., Li, W., Bird, G. C., Bhave, G. B., & Gereau, R. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00052.2003 · Cited by 249 · see citing works

Calcium-Permeable AMPA Receptor Plasticity Is Mediated by Subunit-Specific Interactions with PICK1 and NSF

Gardner, S. M., Takamiya, K., Xia, J., Suh, J., Johnson, R. C., Yu, S., & Huganir, R. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.026 · Cited by 245 · see citing works

Tyrosine Phosphorylation of the NR2B Subunit of the NMDA Receptor in the Spinal Cord during the Development and Maintenance of Inflammatory Hyperalgesia

Guo, W., Zou, S., Guan, Y., Ikeda, T., Tal, M., Dubner, R. A., & Ren, K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06208.2002 · Cited by 244 · see citing works

Spinal Neurons that Possess the Substance P Receptor Are Required for the Development of Central Sensitization

Khasabov, S. G., Rogers, S. D., Ghilardi, J. R., Peters, C. M., Mantyh, P. W., & Simone, D. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09086.2002 · Cited by 242 · see citing works

Differential Activation of Extracellular Signal-Regulated Protein Kinase in Primary Afferent Neurons Regulates Brain-Derived Neurotrophic Factor Expression after Peripheral Inflammation and Nerve Injury

Obata, K., Yamanaka, H., Dai, Y., Tachibana, T., Fukuoka, T., Tokunaga, A., Yoshikawa, H., & Noguchi, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04117.2003 · Cited by 241 · see citing works

BDNF in sensory neurons and chronic pain

Obata, K., & Noguchi, K. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.01.005 · Cited by 241 · see citing works

Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation

Woolf, C. J., Ma, Q., Allchorne, A. J., & Poole, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02716.1996 · Cited by 238 · see citing works

Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy

Mao, J., Price, D. D., Hayes, R. L., Lü, J., Mayer, D. J., & Frenk, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91368-3 · Cited by 238 · see citing works

Reorganisation of spinal cord sensory map after peripheral nerve injury

Devor, M. G., & Wall, P. D. (1978) · Nature · doi:10.1038/276075a0 · Cited by 237 · see citing works

Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge

Seltzer, Z., Cohn, S., Ginzburg, R., & Beilin, B. (1991) · Pain · doi:10.1016/0304-3959(91)90166-u · Cited by 234 · see citing works

Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CAl pyramidal cell dendrites

Regehr, W. G., & Tank, D. W. (1990) · Nature · doi:10.1038/345807a0 · Cited by 234 · see citing works

Microglia

van Rossum, D., & Hanisch, U. (2004) · Metabolic Brain Disease · doi:10.1023/b:mebr.0000043984.73063.d8 · Cited by 234 · see citing works

Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain

Polgár, E., Hughes, D. I., Riddell, J. S., Maxwell, J., Puskár, Z., & Todd, J. A. (2003) · Pain · doi:10.1016/s0304-3959(03)00011-3 · Cited by 232 · see citing works

Temporal Summation of Second Pain and Its Maintenance Are Useful for Characterizing Widespread Central Sensitization of Fibromyalgia Patients

Staud, R. M., Robinson, M. E., & Price, D. D. (2007) · Journal of Pain · doi:10.1016/j.jpain.2007.06.006 · Cited by 232 · see citing works

Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain

Abbadie, C., Brown, J. L., Mantyh, P. W., & Basbaum, A. I. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00343-h · Cited by 230 · see citing works

Direct Activation of Rat Spinal Dorsal Horn Neurons by Prostaglandin E2

Baba, H., Kohno, T., Moore, K. A., & Woolf, C. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01750.2001 · Cited by 228 · see citing works

Calcium–Calmodulin-Dependent Protein Kinase II Contributes to Spinal Cord Central Sensitization

Fang, L., Wu, J., Lin, Q., & Willis, W. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-04196.2002 · Cited by 226 · see citing works

Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture

Vasko, M., Campbell, W., & Waite, K. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04987.1994 · Cited by 226 · see citing works

Molecular anatomy of the postsynaptic density.

Okabe, S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.006 · Cited by 225 · see citing works

Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat

Arvidsson, J., Ygge, J., & Grant, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90310-0 · Cited by 225 · see citing works

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

Chéret, C., Gervais, A., Lelli, A., Colin, C., Amar, L., Ravassard, P., Mallet, J., Cumano, A., Krause, K.-H., & Mallat, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3568-08.2008 · Cited by 225 · see citing works

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

Dougherty, P. M., & Willis, W. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00883.1992 · Cited by 222 · see citing works

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

Liu, X. J., Gingrich, J. R., Vargas‐Caballero, M., Dong, Y., Sengar, A. S., Beggs, S., Wang, S., Ding, H. K., Frankland, P. W., & Salter, M. W. (2008) · Nature Medicine · doi:10.1038/nm.1883 · Cited by 222 · see citing works

Role of central sensitization in symptoms beyond muscle pain, and the evaluation of a patient with widespread pain

Yunus, M. B. (2007) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2007.03.006 · Cited by 219 · see citing works

Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain

Woolf, C. J. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0040 · Cited by 218 · see citing works

Long-term potentiation in spinothalamic neurons

Willis, W. D. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00202-3 · Cited by 213 · see citing works

CNS‐infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection‐induced neuropathic pain

Cao, L., & DeLeo, J. A. (2008) · European Journal of Immunology · doi:10.1002/eji.200737485 · Cited by 212 · see citing works

NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex

Hanley, J. G., Khatri, L., Hanson, P. I., & Ziff, E. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00638-4 · Cited by 197 · see citing works

Synapse-Associated Protein-97 Isoform-Specific Regulation of Surface AMPA Receptors and Synaptic Function in Cultured Neurons

Rumbaugh, G., Sia, G., Garner, C., & Huganir, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04567.2003 · Cited by 197 · see citing works

S-Nitrosylation of N-Ethylmaleimide Sensitive Factor Mediates Surface Expression of AMPA Receptors

Huang, Y., Man, H., Sekine‐Aizawa, Y., Han, Y., Juluri, K. R., Luo, H. R., Cheah, J. H., Lowenstein, C. J., Huganir, R. L., & Snyder, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.028 · Cited by 189 · see citing works

A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain

South, S. M., Kohno, T., Kaspar, B. K., Hegarty, D. M., Vissel, B., Drake, C. T., Ohata, M., Jenab, S., Sailer, A. W., Malkmus, S. A., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05031.2003 · Cited by 187 · see citing works

The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury

Coderre, T. J., & Melzack, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03671.1992 · Cited by 187 · see citing works

Inflammation Increases the Distribution of Dorsal Horn Neurons That Internalize the Neurokinin-1 Receptor in Response to Noxious and Non-Noxious Stimulation

Abbadie, C., Trafton, J. A., Liu, H., Mantyh, P. W., & Basbaum, A. I. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-08049.1997 · Cited by 186 · see citing works

PICK1 and Phosphorylation of the Glutamate Receptor 2 (GluR2) AMPA Receptor Subunit Regulates GluR2 Recycling after NMDA Receptor-Induced Internalization

Lin, D.-T., & Huganir, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1750-07.2007 · Cited by 186 · see citing works

“Listening” and “talking” to neurons: implications of immune activation for pain control and increasing the efficacy of opioids

Watkins, L. R., Hutchinson, M. R., Milligan, E. D., & Maier, S. F. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.006 · Cited by 185 · see citing works

A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors

Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works

An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity.

Terashima, A., Pelkey, K., Rah, J., Suh, Y. H., Roche, K., Collingridge, G., McBain, C., & Isaac, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.028 · Cited by 185 · see citing works

Evidence of involvement of central neural mechanisms in generating fibromyalgia pain

Staud, R. M. (2002) · Current Rheumatology Reports · doi:10.1007/s11926-002-0038-5 · Cited by 183 · see citing works

Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain

Qu, X.-X., Cai, J., Li, M.-J., Chi, Y.-N., Liao, F., Liu, F., Wan, Y., Han, J., & Xing, G. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.10.018 · Cited by 182 · see citing works

Potentiation of sensory responses in the anterior cingulate cortex following digit amputation in the anaesthetised rat

Wei, F., & Zhuo, M. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0823e.x · Cited by 182 · see citing works

Calcitonin Gene-Related Peptide Receptor Activation Produces PKA- and PKC-Dependent Mechanical Hyperalgesia and Central Sensitization

Sun, R.-Q., Tu, Y., Lawand, N., Yan, J.-Y., Lin, Q., & Willis, W. D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00339.2004 · Cited by 180 · see citing works

State-dependent Ras signaling and AMPA receptor traffickingPreprint

Qin, Y., Zhu, Y., Baumgart, J. P., Stornetta, R. L., Seidenman, K. J., Mack, V., Aelst, L. V., & Zhu, J. (2005) · Genes & Development · doi:10.1101/gad.342205 · Cited by 177 · see citing works

Innocuous, Not Noxious, Input Activates PKCγ Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers

Neumann, S., Braz, J. M., Skinner, K., Llewellyn‐Smith, I. J., & Basbaum, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1259-08.2008 · Cited by 175 · see citing works

Progressive tactile hypersensitivity: an inflammation-induced incremental increase in the excitability of the spinal cord

Ma, Q., & Woolf, C. J. (1996) · Pain · doi:10.1016/0304-3959(96)03105-3 · Cited by 174 · see citing works

Central sensitization: implications for the diagnosis and treatment of pain

Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771 · see citing works

Cellular and Molecular Mechanisms of Pain

Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works

Neuropathic Pain: From Mechanisms to Treatment

Finnerup, N. B., Kuner, R., & Jensen, T. S. (2020) · Physiological Reviews · doi:10.1152/physrev.00045.2019 · Cited by 1,628 · see citing works

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630 · see citing works

Nociceptors: the sensors of the pain pathway

Dubin, A. E., & Patapoutian, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42843 · Cited by 1,418 · see citing works

Glia and pain: Is chronic pain a gliopathy?

Ji, R., Berta, T., & Nedergaard, M. (2013) · Pain · doi:10.1016/j.pain.2013.06.022 · Cited by 1,193 · see citing works

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976 · see citing works

Pathological pain and the neuroimmune interface

Grace, P. M., Hutchinson, M. R., Maier, S. F., & Watkins, L. R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3621 · Cited by 951 · see citing works

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

von Hehn, C. A., Baron, R., & Woolf, C. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.008 · Cited by 804 · see citing works

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Chen, G., Zhang, Y., Qadri, Y. J., Serhan, C. N., & Ji, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.009 · Cited by 791 · see citing works

The Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain

Old, E. A., Clark, A. K., & Malcangio, M. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-46450-2_8 · Cited by 658 · see citing works

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

Austin, P. J., & Moalem-Taylor, G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.013 · Cited by 607 · see citing works

What is this thing called pain?

Woolf, C. J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45178 · Cited by 610 · see citing works

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

Iyengar, S., Ossipov, M. H., & Johnson, K. W. (2017) · Pain · doi:10.1097/j.pain.0000000000000831 · Cited by 592 · see citing works

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

Matsuda, M., Huh, Y., & Ji, R. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2579-4 · Cited by 570 · see citing works

Astrocytes in chronic pain and itch

Ji, R., Donnelly, C. R., & Nedergaard, M. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0218-1 · Cited by 553 · see citing works

An artificial nociceptor based on a diffusive memristor

Yoon, J. H., Wang, Z., Kim, K. M., Wu, H., Ravichandran, V., Xia, Q., Hwang, C. S., & Yang, J. J. (2018) · Nature Communications · doi:10.1038/s41467-017-02572-3 · Cited by 525 · see citing works

Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial

Ryan, N., Birring, S. S., & Gibson, P. G. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60776-4 · Cited by 503 · see citing works

Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

Scheffer, D. D. L., & Latini, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165823 · Cited by 509 · see citing works

Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy

Sloan, G., Selvarajah, D., & Tesfaye, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00496-z · Cited by 534 · see citing works

Pain and immunity: implications for host defence

Baral, P., Udit, S., & Chiu, I. M. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0147-2 · Cited by 487 · see citing works

Reward and motivation in pain and pain relief

Navratilova, E., & Porreca, F. (2014) · Nature Neuroscience · doi:10.1038/nn.3811 · Cited by 481 · see citing works

Discordance between pain and radiographic severity in knee osteoarthritis: Findings from quantitative sensory testing of central sensitization

Finan, P. H., Buenaver, L. F., Bounds, S. C., Hussain, S., Park, R. J., Haque, U. J., Campbell, C. M., Haythornthwaite, J. A., Edwards, R. R., & Smith, M. T. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34646 · Cited by 473 · see citing works

Neuropathic Pain: Central vs. Peripheral Mechanisms

Meacham, K., Shepherd, A. J., Mohapatra, D. P., & Haroutounian, S. (2017) · Current Pain and Headache Reports · doi:10.1007/s11916-017-0629-5 · Cited by 462 · see citing works

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

Ross, S. E., Mardinly, A. R., McCord, A. E., Zurawski, J. D., Cohen, S., Jung, C. C., Hu, L. S., Mok, S. I., Shah, A., Savner, E. M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.025 · Cited by 445 · see citing works

Sickle cell pain: a critical reappraisal

Ballas, S. K., Gupta, K., & Adams-Graves, P. E. (2012) · Blood · doi:10.1182/blood-2012-04-383430 · Cited by 442 · see citing works

Persistent Postsurgical Pain

Richebé, P., Capdevila, X., & Rivat, C. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002238 · Cited by 439 · see citing works

Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

Carozzi, V., Canta, A., & Chiorazzi, A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.10.014 · Cited by 436 · see citing works

Prosthesis with neuromorphic multilayered e-dermis perceives touch and pain

Osborn, L. E., Dragomir, A., Betthauser, J. L., Hunt, C. L., Nguyen, H. H., Kaliki, R. R., & Thakor, N. V. (2018) · Science Robotics · doi:10.1126/scirobotics.aat3818 · Cited by 427 · see citing works

Interleukin-6: an emerging regulator of pathological pain

Zhou, Y., Liu, Z., Liu, Z., Chen, S., Li, M., Shahveranov, A., Ye, D., & Tian, Y. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0607-6 · Cited by 418 · see citing works

Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKMζ in the Anterior Cingulate Cortex

Li, X., Ko, H., Chen, T., Descalzi, G., Koga, K., Wang, H., Kim, S. S., Shang, Y., Kwak, C., Park, S., et al. (2010) · Science · doi:10.1126/science.1191792 · Cited by 407 · see citing works

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

Yang, S., & Chang, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133130 · Cited by 410 · see citing works

Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential

Guo, R., Chen, L., Xing, C., & Liu, T. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.07.026 · Cited by 416 · see citing works

Etiology and Pharmacology of Neuropathic Pain

Alles, S. R. A., & Smith, P. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014399 · Cited by 395 · see citing works

Chronic Pain-Related Remodeling of Cerebral Cortex – ‘Pain Memory‘: A Possible Target for Treatment of Chronic Pain

Lithwick, A., Lev, S., & Binshtok, A. M. (2012) · Pain Management · doi:10.2217/pmt.12.74 · Cited by 388 · see citing works

Breaking barriers to novel analgesic drug development

Yekkirala, A. S., Roberson, D. P., Bean, B. P., & Woolf, C. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.87 · Cited by 366 · see citing works

Interaction Between Pain, Movement, and Physical Activity

Hodges, P. W., & Smeets, R. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000098 · Cited by 359 · see citing works

Alcohol dependence as a chronic pain disorder

Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347 · see citing works

Emerging roles of resolvins in the resolution of inflammation and pain

Ji, R., Xu, Z., Strichartz, G. R., & Serhan, C. N. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.005 · Cited by 345 · see citing works

Calcium-Permeable Ion Channels in Pain Signaling

Bourinet, E., Altier, C., Hildebrand, M. E., Trang, T., Salter, M. W., & Zamponi, G. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00023.2013 · Cited by 335 · see citing works

Osteoarthritis: the genesis of pain

Fu, K., Robbins, S. R., & McDougall, J. J. (2017) · Lara D. Veeken · doi:10.1093/rheumatology/kex419 · Cited by 331 · see citing works

Challenges of neuropathic pain: focus on diabetic neuropathy

Rosenberger, D. C., Blechschmidt, V., Timmerman, H., Wolff, A. P., & Treede, R. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02145-7 · Cited by 343 · see citing works

Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective

Kaniušas, E., Kampusch, S., Tittgemeyer, M., Panetsos, F., Gines, R. F., Papa, M., Kiss, A., Podesser, B. K., Cassara, A. M., Tanghe, E., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00854 · Cited by 331 · see citing works

Toward a Mechanism-Based Approach to Pain Diagnosis

Vardeh, D., Mannion, R., & Woolf, C. J. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.03.001 · Cited by 322 · see citing works

Pain and motor control: From the laboratory to rehabilitation

Hodges, P. W. (2011) · Journal of Electromyography and Kinesiology · doi:10.1016/j.jelekin.2011.01.002 · Cited by 321 · see citing works

Towards a mechanism-based approach to pain management in osteoarthritis

Malfait, A., & Schnitzer, T. J. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.138 · Cited by 310 · see citing works

Does inflammation have a role in migraine?

Edvinsson, L. I., Haanes, K. A., & Warfvinge, K. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0216-y · Cited by 312 · see citing works

Antidepressants and gabapentinoids in neuropathic pain: Mechanistic insights

Kremer, M., Salvat, É., Muller, A., Yalçın, İ., & Barrot, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.057 · Cited by 310 · see citing works

Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Cho, Y., Jeong, S., Kim, H., Kang, D., Lee, J., Kang, S., & Kim, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00710-y · Cited by 307 · see citing works

Magnetic Resonance Spectroscopy to Assess NeuroInflammation and Neuropathic Pain

Chang, L., Munsaka, S. M., Kraft-Terry, S. D., & Ernst, T. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9460-x · Cited by 306 · see citing works

Orofacial pain management: current perspectives

Romero‐Reyes, M., & Uyanik, J. M. (2014) · Journal of Pain Research · doi:10.2147/jpr.s37593 · Cited by 303 · see citing works

Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain

Donnelly, C. R., Andriessen, A. S., Chen, G., Wang, K., Jiang, C., Maixner, W. D., & Ji, R. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00905-7 · Cited by 302 · see citing works

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions

Staud, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.41 · Cited by 290 · see citing works

The Pain of Tendinopathy: Physiological or Pathophysiological?

Rio, E., Moseley, G. L., Purdam, C. R., Samiric, T., Kidgell, D. J., Pearce, A. J., Jaberzadeh, S. J., & Cook, J. L. (2013) · Sports Medicine · doi:10.1007/s40279-013-0096-z · Cited by 287 · see citing works

Neuroplasticity Underlying the Comorbidity of Pain and Depression

Doan, L., Manders, T. R., & Wang, J. (2015) · Neural Plasticity · doi:10.1155/2015/504691 · Cited by 284 · see citing works

Peripheral input and its importance for central sensitization

Baron, R., Hans, G. H., & Dickenson, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.24017 · Cited by 280 · see citing works

Central changes associated with chronic pelvic pain and endometriosis

Brawn, J., Morotti, M., Zondervan, K. T., Becker, C. M., & Vincent, K. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu025 · Cited by 274 · see citing works

Fibromyalgia: A Critical and Comprehensive Review

Borchers, A. T., & Gershwin, M. E. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8509-4 · Cited by 279 · see citing works

The cannabinoid system and pain

Woodhams, S. G., Chapman, V., Finn, D. P., Hohmann, A. G., & Neugebauer, V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.015 · Cited by 272 · see citing works

Early Neonatal Pain—A Review of Clinical and Experimental Implications on Painful Conditions Later in Life

Williams, M. D., & Lascelles, B. D. X. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00030 · Cited by 271 · see citing works

Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms

Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23802 · Cited by 268 · see citing works

The neurobiology of irritable bowel syndrome

Mayer, E. A., Ryu, H. J., & Bhatt, R. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01972-w · Cited by 285 · see citing works

Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates

Steinhoff, M. S., Suárez, A., Feramisco, J. D., & Koo, J. Y. M. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1188 · Cited by 264 · see citing works

Reframing chronic pain as a disease, not a symptom: rationale and implications for pain management

Clauw, D. J., Essex, M. N., Pitman, V. W., & Jones, K. D. (2019) · Postgraduate Medicine · doi:10.1080/00325481.2019.1574403 · Cited by 262 · see citing works

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

He, W., Long, T., Pan, Q., Zhang, S., Zhang, Y., Zhang, D., Qin, G., Chen, L., & Zhou, J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1459-7 · Cited by 258 · see citing works

Visceral pain

Sikandar, S., & Dickenson, A. H. (2012) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e32834f6ec9 · Cited by 254 · see citing works

American Society for Pain Management Nursing Guidelines on Monitoring for Opioid-Induced Sedation and Respiratory Depression

Jarzyna, D., Jungquist, C. R., Pasero, C., Willens, J. S., Nisbet, A., Oakes, L. L., Dempsey, S. J., Santangelo, D., & Polomano, R. C. (2011) · Pain Management Nursing · doi:10.1016/j.pmn.2011.06.008 · Cited by 253 · see citing works

Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients

Harris, R. E., Napadow, V., Huggins, J. P., Pauer, L., Kim, J., Hampson, J. P., Sundgren, P. C., Foerster, B. R., Petrou, M., Schmidt‐Wilcke, T., et al. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000017 · Cited by 253 · see citing works

Toll-like receptors in chronic pain

Nicotra, L. L., Loram, L. C., Watkins, L. R., & Hutchinson, M. R. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.038 · Cited by 250 · see citing works

Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action

Caylor, J. R., Reddy, R. D., Yin, S., Cui, C. L., Huang, M., Huang, C. W., Rao, R., Baker, D. G., Simmons, A. N., Souza, D., et al. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0023-1 · Cited by 246 · see citing works

Constitutive μ-Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence

Corder, G., Doolen, S., Donahue, R. R., Winter, M. K., Jutras, B. L., He, Y., Hu, X., Wieskopf, J. S., Mogil, J. S., Storm, D. R., et al. (2013) · Science · doi:10.1126/science.1239403 · Cited by 240 · see citing works

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

Ruscheweyh, R., Wilder‐Smith, O. H. G., Drdla-Schutting, R., Liu, X., & Sandkühler, J. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-20 · Cited by 236 · see citing works

Relating Chronic Pelvic Pain and Endometriosis to Signs of Sensitization and Myofascial Pain and Dysfunction

Aredo, J., Heyrana, K., Karp, B., Shah, J., & Stratton, P. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0036-1597123 · Cited by 208 · see citing works

Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment

Tracey, I., Woolf, C. J., & Andrews, N. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.019 · Cited by 231 · see citing works

Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis

Georgopoulos, V., Akin-Akinyosoye, K., Zhang, W., McWilliams, D. F., Hendrick, P. A., & Walsh, D. A. (2019) · Pain · doi:10.1097/j.pain.0000000000001590 · Cited by 231 · see citing works

Pain and Problem Behavior in Cats and Dogs

Mills, D. S., Demontigny-Bédard, I., Gruen, M. E., Klinck, M. P., McPeake, K. J., Barcelos, A. M., Hewison, L., Haevermaet, H. V., Denenberg, S., Hauser, H., et al. (2020) · Animals · doi:10.3390/ani10020318 · Cited by 238 · see citing works

Physiological feelings

Pace-Schott, E. F., Amole, M. C., Aue, T., Balconi, M., Bylsma, L. M., Critchley, H., Demaree, H. A., Friedman, B. H., Gooding, A. E. K., Gosseries, O., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.002 · Cited by 221 · see citing works

Clinical biopsychosocial physiotherapy assessment of patients with chronic pain: The first step in pain neuroscience education

Wijma, A. J., van Wilgen, C. P., Meeus, M., & Nijs, J. (2016) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2016.1194651 · Cited by 222 · see citing works

Medication overuse headache

Ashina, S., Terwindt, G. M., Steiner, T. J., Lee, M. J., Porreca, F., Tassorelli, C., Schwedt, T. J., Jensen, R., Diener, H., & Lipton, R. B. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00415-0 · Cited by 223 · see citing works

Fear-avoidance beliefs and pain avoidance in low back pain--translating research into clinical practice.

Rainville, J., Smeets, R., Bendix, T., Tveito, T., Poiraudeau, S., & Indahl, A. (2011) · The spine journal · doi:10.1016/j.spinee.2011.08.006 · Cited by 209 · see citing works

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management

Vanderwall, A. G., & Milligan, E. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03009 · Cited by 219 · see citing works

Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats

Serra, J., Bostock, H., Solà, R., Aleu, J., García, E., Cokić, B., Navarro, X., & Quiles, C. (2011) · Pain · doi:10.1016/j.pain.2011.08.015 · Cited by 216 · see citing works

The Jak/STAT pathway: A focus on pain in rheumatoid arthritis

Simon, L. S., Taylor, P. C., Choy, E., Sebba, A. I., Quebe, A. K., Knopp, K. L., & Porreca, F. (2020) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.10.008 · Cited by 222 · see citing works

Overcoming obstacles to developing new analgesics

Woolf, C. J. (2010) · Nature Medicine · doi:10.1038/nm.2230 · Cited by 214 · see citing works

Preclinical Assessment of Inflammatory Pain

Muley, M. M., Krustev, E., & McDougall, J. J. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12486 · Cited by 209 · see citing works

Complex regional pain syndrome: A comprehensive and critical review

Borchers, A. T., & Gershwin, M. E. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.10.006 · Cited by 206 · see citing works

Toll-like receptors and their role in persistent pain

Lacagnina, M. J., Watkins, L. R., & Grace, P. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.006 · Cited by 210 · see citing works

Neuropathic pain in osteoarthritis: A review of pathophysiological mechanisms and implications for treatment

Dimitroulas, T., Duarte, R. V., Behura, A., Kitas, G. D., & Raphael, J. H. (2014) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2014.05.011 · Cited by 203 · see citing works

Is neuroplasticity in the central nervous system the missing link to our understanding of chronic musculoskeletal disorders?

Pelletier, R., Higgins, J., & Bourbonnais, D. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0480-y · Cited by 202 · see citing works

Artificial Neuron Devices

He, K., Wang, C., He, Y., Su, J., & Chen, X. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00527 · Cited by 202 · see citing works

Association of Chronic Pelvic Pain and Endometriosis With Signs of Sensitization and Myofascial Pain

Stratton, P., Khachikyan, I., Sinaii, N., Ortiz, R., & Shah, J. P. (2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000000663 · Cited by 203 · see citing works

The Corneal Pain System. Part I: The Missing Piece of the Dry Eye Puzzle

Rosenthal, P., & Borsook, D. (2012) · The Ocular Surface · doi:10.1016/j.jtos.2012.01.002 · Cited by 199 · see citing works

Ocular neuropathic pain

Rosenthal, P., & Borsook, D. (2015) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2014-306280 · Cited by 198 · see citing works

Chronic pain, psychopathology, and DSM-5 Somatic Symptom Disorder

Katz, J., Rosenbloom, B. N., & Fashler, S. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000402 · Cited by 195 · see citing works

Mechanisms of Cardiac Pain

Foreman, R. D., Garrett, K. M., & Blair, R. W. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140032 · Cited by 194 · see citing works

Mechanisms-based classifications of musculoskeletal pain: Part 1 of 3: Symptoms and signs of central sensitisation in patients with low back (±leg) pain

Smart, K. M., Blake, C. M., Staines, A. S., Thacker, M. A., & Doody, C. (2012) · Manual Therapy · doi:10.1016/j.math.2012.03.013 · Cited by 193 · see citing works

Best Exercise Options for Reducing Pain and Disability in Adults With Chronic Low Back Pain: Pilates, Strength, Core-Based, and Mind-Body. A Network Meta-analysis

Fernández‐Rodríguez, R., Álvarez‐Bueno, C., Cavero‐Redondo, I., Torres-Costoso, A. I., Pozuelo‐Carrascosa, D. P., Reina‐Gutiérrez, S., Pascual‐Morena, C., & Martínez‐Vizcaíno, V. (2022) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2022.10671 · Cited by 202 · see citing works

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

Bennett, G. J., Doyle, T. M., & Salvemini, D. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.77 · Cited by 191 · see citing works

A Sub‐10 nm Vertical Organic/Inorganic Hybrid Transistor for Pain‐Perceptual and Sensitization‐Regulated Nociceptor Emulation

Feng, G., Jiang, J., Zhao, Y., Wang, S., Liu, B., Yin, K., Niu, D., Li, X., Chen, Y., Duan, H., et al. (2019) · Advanced Materials · doi:10.1002/adma.201906171 · Cited by 191 · see citing works

METTL3 plays multiple functions in biological processes.

Liu, S., Zhuo, L., Wang, J., Zhang, Q., Li, Q., Li, G., Yan, L., Jin, T., Pan, T. S., Sui, X., et al. (2020) · PubMed Central · Cited by 191 · see citing works

Available online at www.sciencedirect.com Critical Review Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

Latrémolière, A., & Woolf, C. J. (2013)

Pain and Plasticity

Ji, R., & Kawasaki, Y. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01931-8

Central nervous system plasticity and persistent pain.

Ren, K., & Dubner, R. A. (1999) · PubMed · Cited by 164 · see citing works

Central sensitization: implications for the diagnosis and treatment of pain

Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771 · see citing works

Peripheral and central sensitization

Ashmawi, H. A., & Freire, G. M. G. (2016) · Revista Dor · doi:10.5935/1806-0013.20160044 · Cited by 46 · see citing works