The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Thyroid Hormone-Responsive Genes in Developing Cerebellum Include a Novel Synaptotagmin and a hairless Homolog
Open accessAbstract
Proper development of the mammalian CNS requires sufficient thyroid hormone; thyroid hormone deficiency during a brief perinatal period produces severe neurological defects in humans and experimental animals. Thyroid hormone exerts its effects through nuclear receptors, which modulate the transcription of downstream genes in response to hormone binding. Surprisingly, few genes that are regulated by thyroid hormone receptors in the CNS have been described. Here, I report the isolation and characterization of genes that are expressed in response to thyroid hormone in developing rat brain. One such gene (Srg1) encodes a novel protein related to synaptotagmin, a protein involved in regulating neurotransmitter release; another (hr) encodes a putative zinc finger protein related to the product of a recently identified mouse gene,hairless. Both Srg1 and hr are induced rapidly (<4 hr), suggesting that they are regulated directly by thyroid hormone. The temporal and spatial expression of both Srg1 and hr is characteristic of genes important to nervous system development.Srg1 and hr are likely part of a cascade of gene activation induced by thyroid hormone that is critical for CNS organization and development.
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483
Altman, J. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450402 · Cited by 996
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
Davletov, B. A., & Südhof, T. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74326-9 · Cited by 480 · cited 1×
“The N-terminal C2 domain (C2-A) of multiple synaptotagmins has been shown to bind Ca21 and phospholipids (Davletov and Sudhof, 1993; Li et al., 1995).”
Background
Cited by
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
Alopecia Universalis Associated with a Mutation in the Human hairless Gene
Ahmad, W., Faiyaz ul Haque, M., Brancolini, V., Tsou, H. C., ul Haque, S., Lam, H., Aita, V. M., Owen, J., deBlaquiere, M., Frank, J., et al. (1998) · Science · doi:10.1126/science.279.5351.720 · Cited by 409
The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain
Guadaño-Ferraz, A., Obregón, M. J., Germain, D. L. S., & Bernal, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10391 · Cited by 372
Action of thyroid hormone in brain
Bernal, J. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344003 · Cited by 358
Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
Lang, J. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00043.x · Cited by 347
Metadata
- Authors
- Thompson, C. C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-12-15
- Volume
- 16
- Issue
- 24
- Pages
- 7832-7840
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2110945660
- Cited by
- 191
- References
- 4
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Thompson, C. C. (1996). Thyroid Hormone-Responsive Genes in Developing Cerebellum Include a Novel Synaptotagmin and a hairless Homolog. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.16-24-07832.1996
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