Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
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Mice carrying a mutation in the synaptotagmin I gene were generated by homologous recombination. Mutant mice are phenotypically normal as heterozygotes, but die within 48 hr after birth as homozygotes. Studies of hippocampal neurons cultured from homozygous mutant mice reveal that synaptic transmission is severely impaired. The synchronous, fast component of Ca(2+)-dependent neurotransmitter release is decreased, whereas asynchronous release processes, including spontaneous synaptic activity (miniature excitatory postsynaptic current frequency) and release triggered by hypertonic solution or alpha-latrotoxin, are unaffected. Our findings demonstrate that synaptotagmin I function is required for Ca2+ triggering of synchronous neurotransmitter release, but is not essential for asynchronous or Ca(2+)-independent release. We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons.
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Synaptotagmin-1 (Syt1) is a Ca2+ sensor for evoked synchronous neurotransmitter release.
“Among these isoforms, synaptotagmin-1 (Syt1) is a Ca2+ sensor for evoked synchronous neurotransmitter release7.”
From Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis (2015) · cites this paper as [7]
Removal of Syt1 abolished synchronous release monitored by eIPSCs, a phenotype rescued by re-introduction of WT but not mutant Syt1 cDNA.
“As expected7, removal of Syt1 abolished synchronous release monitored by recording evoked inhibitory postsynaptic currents (eIPSCs), a phenotype that can be rescued by re-introduction of WT but not mutant Syt1 cDNA (Figs. 4a, b).”
From Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis (2015) · cites this paper as [7]
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- Authors
- Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Salk Institute for Biological Studies (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 79
- Issue
- 4
- Pages
- 717-727
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165302477
- Cited by
- 1,483
- References
- 45
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 34 · 2023: 36 · 2022: 41 · 2021: 42 · 2020: 47 · 2019: 49 · 2018: 43 · 2017: 41 · 2016: 31 · 2015: 41 · 2014: 51 · 2013: 33 · 2012: 59
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (5r01ns012961-22)
- National Institute of Neurological Disorders and Stroke (R0 NS 12961-17)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- synaptotagmin-1, calcium sensor, asynchronous release, calcium-independent release, hippocampal neurons, synaptic transmission, mouse mutants, alpha-latrotoxin, spontaneous synaptic activity
- MeSH terms
- Animals, Animals, Newborn, Base Sequence, Brain, Calcium, Calcium-Binding Proteins, Exons, Hippocampus, Homozygote, Hypertonic Solutions, Membrane Glycoproteins, Mice, Neurologic Mutants, Molecular Sequence Data, Mutation, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Reference Values, Spider Venoms, Synapses, Restriction Mapping, Polymerase Chain Reaction, Mutagenesis, DNA Primers, Neurotransmitter Agents, Synaptotagmins, Synaptotagmin I, Mice
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